Extending the models for XX and XO data, so as to keep a consensus network as far as possible.
Steps to find the common link to be added :
1.) Read in the extension.csv for both cell lines
2.) Remove links from TFs and Ligands
3.) Retain only links that have adjusted p-value < 0.001 and value !=0
4.) Calculate %improvement in residual for each cell line
5.) Find the intersection list,(Links that appear in both lists)
6.) Calculate the sum of %improvement in residual
7.) Order the intersection list by descending order of sum of %improvement in residual.
8.) Add the link with Max sum of %improvement to both models.
Link_Selection
Init
XX : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
178
|
Gsk3
|
Igfr
|
1.41702633999479
|
1277.72293709044
|
18
|
778.579
|
2
|
0
|
0
|
Gsk3_Igfr
|
2056.30193709044
|
37.86
|
|
2
|
171
|
Gsk3
|
Akt
|
1.99559218209568
|
1288.71968912995
|
18
|
767.582
|
2
|
0
|
0
|
Gsk3_Akt
|
2056.30168912995
|
37.33
|
|
3
|
183
|
Gsk3
|
Pi3k
|
15.0727241980515
|
1289.13219166705
|
18
|
767.169
|
2
|
0
|
0
|
Gsk3_Pi3k
|
2056.30119166705
|
37.31
|
|
4
|
176
|
Gsk3
|
Fgfr
|
0.191531955466209
|
1372.05906755829
|
18
|
684.242
|
2
|
0
|
0
|
Gsk3_Fgfr
|
2056.30106755829
|
33.28
|
|
5
|
220
|
Jak
|
Igfr
|
0.0556087755678092
|
1503.11324628534
|
17
|
553.188
|
1
|
0
|
0
|
Jak_Igfr
|
2056.30124628534
|
26.9
|
|
6
|
218
|
Jak
|
Fgfr
|
0.0167866219398153
|
1515.31854382928
|
17
|
540.983
|
1
|
0
|
0
|
Jak_Fgfr
|
2056.30154382928
|
26.31
|
|
7
|
225
|
Jak
|
Pi3k
|
0.386430781716265
|
1519.02257765008
|
17
|
537.279
|
1
|
0
|
0
|
Jak_Pi3k
|
2056.30157765008
|
26.13
|
|
8
|
213
|
Jak
|
Akt
|
0.0299202958574827
|
1523.34265280937
|
17
|
532.959
|
1
|
0
|
0
|
Jak_Akt
|
2056.30165280937
|
25.92
|
|
9
|
92
|
Bmp4r
|
Fgfr
|
100.000006308235
|
1854.77449547632
|
18
|
201.527
|
2
|
0
|
0
|
Bmp4r_Fgfr
|
2056.30149547632
|
9.8
|
|
10
|
29
|
Actr
|
Fgfr
|
-0.792450311159814
|
1894.64741080012
|
17
|
161.654
|
1
|
0
|
0
|
Actr_Fgfr
|
2056.30141080012
|
7.86
|
|
11
|
27
|
Actr
|
Erk
|
-0.753277209074847
|
1908.45360160677
|
17
|
147.848
|
1
|
0
|
0
|
Actr_Erk
|
2056.30160160677
|
7.19
|
|
12
|
34
|
Actr
|
Mek
|
-0.179931092631044
|
1930.52896307973
|
17
|
125.773
|
1
|
0
|
0
|
Actr_Mek
|
2056.30196307973
|
6.12
|
|
13
|
37
|
Actr
|
Raf
|
-0.179931092631044
|
1930.52896307973
|
17
|
125.773
|
1
|
0
|
0
|
Actr_Raf
|
2056.30196307973
|
6.12
|
|
14
|
38
|
Actr
|
Ras
|
-0.179931092631044
|
1930.52896307973
|
17
|
125.773
|
1
|
0
|
0
|
Actr_Ras
|
2056.30196307973
|
6.12
|
|
15
|
90
|
Bmp4r
|
Erk
|
1.00254227701165
|
1945.00798062694
|
18
|
111.293
|
2
|
0
|
0
|
Bmp4r_Erk
|
2056.30098062694
|
5.41
|
|
16
|
94
|
Bmp4r
|
Igfr
|
0.195835877555398
|
1946.07972998386
|
18
|
110.222
|
2
|
0
|
0
|
Bmp4r_Igfr
|
2056.30172998386
|
5.36
|
|
17
|
241
|
Lifr
|
Igfr
|
-8.64959120556414
|
1951.984753853
|
17
|
104.317
|
1
|
0
|
0
|
Lifr_Igfr
|
2056.301753853
|
5.07
|
|
18
|
99
|
Bmp4r
|
Pi3k
|
0.099135408617148
|
1952.17922272236
|
18
|
104.122
|
2
|
0
|
0
|
Bmp4r_Pi3k
|
2056.30122272236
|
5.06
|
|
19
|
87
|
Bmp4r
|
Akt
|
10.0000009020694
|
1957.94804413658
|
18
|
98.353
|
2
|
0
|
0
|
Bmp4r_Akt
|
2056.30104413658
|
4.78
|
|
20
|
246
|
Lifr
|
Pi3k
|
-33.0916817789231
|
1962.46600501336
|
17
|
93.835
|
1
|
0
|
0
|
Lifr_Pi3k
|
2056.30100501336
|
4.56
|
XO : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
218
|
Jak
|
Fgfr
|
20.4555622071971
|
1087.3433154512
|
17
|
516.38
|
1
|
0
|
0
|
Jak_Fgfr
|
1603.7233154512
|
32.2
|
|
2
|
216
|
Jak
|
Erk
|
0.694604520012992
|
1259.70107127078
|
17
|
344.022
|
1
|
0
|
0
|
Jak_Erk
|
1603.72307127078
|
21.45
|
|
3
|
223
|
Jak
|
Mek
|
0.15351221946598
|
1274.91766666864
|
17
|
328.806
|
1
|
0
|
0
|
Jak_Mek
|
1603.72366666864
|
20.5
|
|
4
|
226
|
Jak
|
Raf
|
0.15351221946598
|
1274.91766666864
|
17
|
328.806
|
1
|
0
|
0
|
Jak_Raf
|
1603.72366666864
|
20.5
|
|
5
|
227
|
Jak
|
Ras
|
0.15351221946598
|
1274.91766666864
|
17
|
328.806
|
1
|
0
|
0
|
Jak_Ras
|
1603.72366666864
|
20.5
|
|
6
|
239
|
Lifr
|
Fgfr
|
-22.8862756816318
|
1284.20827339159
|
17
|
319.515
|
1
|
0
|
0
|
Lifr_Fgfr
|
1603.72327339159
|
19.92
|
|
7
|
237
|
Lifr
|
Erk
|
-1.09664060760853
|
1307.81404086072
|
17
|
295.909
|
1
|
0
|
0
|
Lifr_Erk
|
1603.72304086072
|
18.45
|
|
8
|
244
|
Lifr
|
Mek
|
-0.239871706973556
|
1311.08678087424
|
17
|
292.637
|
1
|
0
|
0
|
Lifr_Mek
|
1603.72378087424
|
18.25
|
|
9
|
247
|
Lifr
|
Raf
|
-0.239871706973556
|
1311.08678087424
|
17
|
292.637
|
1
|
0
|
0
|
Lifr_Raf
|
1603.72378087424
|
18.25
|
|
10
|
248
|
Lifr
|
Ras
|
-0.239871706973556
|
1311.08678087424
|
17
|
292.637
|
1
|
0
|
0
|
Lifr_Ras
|
1603.72378087424
|
18.25
|
|
11
|
220
|
Jak
|
Igfr
|
0.444980919815384
|
1339.66671380804
|
17
|
264.057
|
1
|
0
|
0
|
Jak_Igfr
|
1603.72371380804
|
16.47
|
|
12
|
225
|
Jak
|
Pi3k
|
23.8145409083589
|
1343.76983210708
|
17
|
259.954
|
1
|
0
|
0
|
Jak_Pi3k
|
1603.72383210708
|
16.21
|
|
13
|
213
|
Jak
|
Akt
|
0.100341243030155
|
1355.56166278988
|
17
|
248.162
|
1
|
0
|
0
|
Jak_Akt
|
1603.72366278988
|
15.47
|
|
14
|
118
|
Erk
|
Mek
|
-0.964630137460665
|
1360.97895223146
|
17
|
242.744
|
1
|
0
|
0
|
Erk_Mek
|
1603.72295223146
|
15.14
|
|
15
|
121
|
Erk
|
Raf
|
-0.964630137460665
|
1360.97895223146
|
17
|
242.744
|
1
|
0
|
0
|
Erk_Raf
|
1603.72295223146
|
15.14
|
|
16
|
122
|
Erk
|
Ras
|
-0.964630137460665
|
1360.97895223146
|
17
|
242.744
|
1
|
0
|
0
|
Erk_Ras
|
1603.72295223146
|
15.14
|
|
17
|
268
|
Mek
|
Raf
|
-3.7643708653117
|
1360.97895223946
|
17
|
242.744
|
1
|
0
|
0
|
Mek_Raf
|
1603.72295223946
|
15.14
|
|
18
|
269
|
Mek
|
Ras
|
-3.76437183759911
|
1360.97895224393
|
17
|
242.744
|
1
|
0
|
0
|
Mek_Ras
|
1603.72295224393
|
15.14
|
|
19
|
219
|
Jak
|
Gsk3
|
0.309068043959635
|
1379.30411367602
|
17
|
224.419
|
1
|
0
|
0
|
Jak_Gsk3
|
1603.72311367602
|
13.99
|
|
20
|
92
|
Bmp4r
|
Fgfr
|
10.0002449611418
|
1416.66260952319
|
18
|
187.061
|
2
|
0
|
0
|
Bmp4r_Fgfr
|
1603.72360952319
|
11.66
|
Intersection List
|
|
Link
|
Res_delta_XX
|
adj_pval_XX
|
Perc_Res_delta_XX
|
Res_delta_XO
|
adj_pval_XO
|
Perc_Res_delta_XO
|
Total_DelResidual
|
Tot_Percentage_DelResidual
|
|
6
|
Jak_Fgfr
|
540.983
|
0
|
26.31
|
516.38
|
0
|
32.2
|
1057.363
|
58.51
|
|
1
|
Gsk3_Igfr
|
778.579
|
0
|
37.86
|
136.041
|
0
|
8.48
|
914.62
|
46.34
|
|
3
|
Gsk3_Pi3k
|
767.169
|
0
|
37.31
|
132.95
|
0
|
8.29
|
900.119
|
45.6
|
|
2
|
Gsk3_Akt
|
767.582
|
0
|
37.33
|
130.764
|
0
|
8.15
|
898.346
|
45.48
|
|
5
|
Jak_Igfr
|
553.188
|
0
|
26.9
|
264.057
|
0
|
16.47
|
817.245
|
43.37
|
|
7
|
Jak_Pi3k
|
537.279
|
0
|
26.13
|
259.954
|
0
|
16.21
|
797.233
|
42.34
|
|
4
|
Gsk3_Fgfr
|
684.242
|
0
|
33.28
|
136.041
|
0
|
8.48
|
820.283
|
41.76
|
|
8
|
Jak_Akt
|
532.959
|
0
|
25.92
|
248.162
|
0
|
15.47
|
781.121
|
41.39
|
|
26
|
Jak_Erk
|
83.477
|
0
|
4.06
|
344.022
|
0
|
21.45
|
427.499
|
25.51
|
|
21
|
Lifr_Fgfr
|
89.61
|
0
|
4.36
|
319.515
|
0
|
19.92
|
409.125
|
24.28
|
|
27
|
Jak_Mek
|
67.087
|
0
|
3.26
|
328.806
|
0
|
20.5
|
395.893
|
23.76
|
|
28
|
Jak_Raf
|
67.087
|
0
|
3.26
|
328.806
|
0
|
20.5
|
395.893
|
23.76
|
|
29
|
Jak_Ras
|
67.087
|
0
|
3.26
|
328.806
|
0
|
20.5
|
395.893
|
23.76
|
|
9
|
Bmp4r_Fgfr
|
201.527
|
0
|
9.8
|
187.061
|
0
|
11.66
|
388.588
|
21.46
|
|
10
|
Actr_Fgfr
|
161.654
|
0
|
7.86
|
184.891
|
0
|
11.53
|
346.545
|
19.39
|
|
11
|
Actr_Erk
|
147.848
|
0
|
7.19
|
159.145
|
0
|
9.92
|
306.993
|
17.11
|
|
36
|
Mek_Raf
|
34.936
|
0
|
1.7
|
242.744
|
0
|
15.14
|
277.68
|
16.84
|
|
37
|
Mek_Ras
|
34.936
|
0
|
1.7
|
242.744
|
0
|
15.14
|
277.68
|
16.84
|
|
38
|
Erk_Mek
|
34.936
|
0
|
1.7
|
242.744
|
0
|
15.14
|
277.68
|
16.84
|
|
39
|
Erk_Raf
|
34.936
|
0
|
1.7
|
242.744
|
0
|
15.14
|
277.68
|
16.84
|
LA1
XX : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
178
|
Gsk3
|
Igfr
|
1.07092508964865
|
971.812846969374
|
19
|
543.189
|
2
|
0
|
0
|
Gsk3_Igfr
|
1515.00184696937
|
35.85
|
|
2
|
171
|
Gsk3
|
Akt
|
1.68236052914573
|
980.75472533061
|
19
|
534.247
|
2
|
0
|
0
|
Gsk3_Akt
|
1515.00172533061
|
35.26
|
|
3
|
183
|
Gsk3
|
Pi3k
|
0.947902586974397
|
981.104897412239
|
19
|
533.897
|
2
|
0
|
0
|
Gsk3_Pi3k
|
1515.00189741224
|
35.24
|
|
4
|
176
|
Gsk3
|
Fgfr
|
0.0366456344380372
|
1042.9909365935
|
19
|
472.011
|
2
|
0
|
0
|
Gsk3_Fgfr
|
1515.0019365935
|
31.16
|
|
5
|
179
|
Gsk3
|
Jak
|
3.57901785216984
|
1186.00515881884
|
19
|
328.997
|
2
|
0
|
0
|
Gsk3_Jak
|
1515.00215881884
|
21.72
|
|
6
|
180
|
Gsk3
|
Lifr
|
3.57012904221758
|
1186.0051592358
|
19
|
328.997
|
2
|
0
|
0
|
Gsk3_Lifr
|
1515.0021592358
|
21.72
|
|
7
|
92
|
Bmp4r
|
Fgfr
|
100.000000018277
|
1379.2932137683
|
19
|
135.709
|
2
|
0
|
0
|
Bmp4r_Fgfr
|
1515.0022137683
|
8.96
|
|
8
|
96
|
Bmp4r
|
Lifr
|
13.860198582644
|
1405.40002957656
|
19
|
109.602
|
2
|
0
|
0
|
Bmp4r_Lifr
|
1515.00202957656
|
7.23
|
|
9
|
95
|
Bmp4r
|
Jak
|
10.0003455473115
|
1405.40002968353
|
19
|
109.602
|
2
|
0
|
0
|
Bmp4r_Jak
|
1515.00202968353
|
7.23
|
|
10
|
90
|
Bmp4r
|
Erk
|
0.0999812891114909
|
1409.88137320982
|
19
|
105.121
|
2
|
0
|
0
|
Bmp4r_Erk
|
1515.00237320982
|
6.94
|
|
11
|
27
|
Actr
|
Erk
|
-0.615066582280294
|
1431.05413356246
|
18
|
83.948
|
1
|
0
|
0
|
Actr_Erk
|
1515.00213356246
|
5.54
|
|
12
|
97
|
Bmp4r
|
Mek
|
0.0950267626764539
|
1432.52845502105
|
19
|
82.474
|
2
|
0
|
0
|
Bmp4r_Mek
|
1515.00245502105
|
5.44
|
|
13
|
100
|
Bmp4r
|
Raf
|
0.0950267626764539
|
1432.52845502105
|
19
|
82.474
|
2
|
0
|
0
|
Bmp4r_Raf
|
1515.00245502105
|
5.44
|
|
14
|
101
|
Bmp4r
|
Ras
|
0.0950267626764539
|
1432.52845502105
|
19
|
82.474
|
2
|
0
|
0
|
Bmp4r_Ras
|
1515.00245502105
|
5.44
|
|
15
|
220
|
Jak
|
Igfr
|
0.368915097530597
|
1435.74303261254
|
18
|
79.259
|
1
|
0
|
0
|
Jak_Igfr
|
1515.00203261254
|
5.23
|
|
16
|
29
|
Actr
|
Fgfr
|
-0.183054053565317
|
1436.60116940405
|
18
|
78.401
|
1
|
0
|
0
|
Actr_Fgfr
|
1515.00216940405
|
5.17
|
|
17
|
262
|
Mek
|
Igfr
|
4.08398310958696
|
1443.43775345878
|
18
|
71.564
|
1
|
0
|
0
|
Mek_Igfr
|
1515.00175345878
|
4.72
|
|
18
|
115
|
Erk
|
Igfr
|
1.20036285529175
|
1443.43775367973
|
18
|
71.564
|
1
|
0
|
0
|
Erk_Igfr
|
1515.00175367973
|
4.72
|
|
19
|
34
|
Actr
|
Mek
|
-0.138837756484627
|
1447.09755458941
|
18
|
67.904
|
1
|
2.22044604925031e-16
|
0
|
Actr_Mek
|
1515.00155458941
|
4.48
|
|
20
|
37
|
Actr
|
Raf
|
-0.138837756484627
|
1447.09755458941
|
18
|
67.904
|
1
|
2.22044604925031e-16
|
0
|
Actr_Raf
|
1515.00155458941
|
4.48
|
XO : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
118
|
Erk
|
Mek
|
-1.3134031405681
|
815.631614385471
|
18
|
247.924
|
1
|
0
|
0
|
Erk_Mek
|
1063.55561438547
|
23.31
|
|
2
|
121
|
Erk
|
Raf
|
-1.3134031405681
|
815.631614385471
|
18
|
247.924
|
1
|
0
|
0
|
Erk_Raf
|
1063.55561438547
|
23.31
|
|
3
|
122
|
Erk
|
Ras
|
-1.3134031405681
|
815.631614385471
|
18
|
247.924
|
1
|
0
|
0
|
Erk_Ras
|
1063.55561438547
|
23.31
|
|
4
|
269
|
Mek
|
Ras
|
-5.83516557728466
|
815.631614406535
|
18
|
247.924
|
1
|
0
|
0
|
Mek_Ras
|
1063.55561440654
|
23.31
|
|
5
|
268
|
Mek
|
Raf
|
-5.83501103034113
|
815.631614489309
|
18
|
247.924
|
1
|
0
|
0
|
Mek_Raf
|
1063.55561448931
|
23.31
|
|
6
|
92
|
Bmp4r
|
Fgfr
|
9.99999909080412
|
953.75112000258
|
19
|
109.805
|
2
|
0
|
0
|
Bmp4r_Fgfr
|
1063.55612000258
|
10.32
|
|
7
|
29
|
Actr
|
Fgfr
|
-0.107633817589381
|
960.885942690023
|
18
|
102.67
|
1
|
0
|
0
|
Actr_Fgfr
|
1063.55594269002
|
9.65
|
|
8
|
97
|
Bmp4r
|
Mek
|
99.9999999996109
|
962.159252464793
|
19
|
101.397
|
2
|
0
|
0
|
Bmp4r_Mek
|
1063.55625246479
|
9.53
|
|
9
|
100
|
Bmp4r
|
Raf
|
99.9999999996109
|
962.159252464793
|
19
|
101.397
|
2
|
0
|
0
|
Bmp4r_Raf
|
1063.55625246479
|
9.53
|
|
10
|
101
|
Bmp4r
|
Ras
|
99.9999999996109
|
962.159252464793
|
19
|
101.397
|
2
|
0
|
0
|
Bmp4r_Ras
|
1063.55625246479
|
9.53
|
|
11
|
179
|
Gsk3
|
Jak
|
0.109872274801102
|
962.880760353095
|
19
|
100.675
|
2
|
0
|
0
|
Gsk3_Jak
|
1063.55576035309
|
9.47
|
|
12
|
180
|
Gsk3
|
Lifr
|
0.109861109481093
|
962.880760387493
|
19
|
100.675
|
2
|
0
|
0
|
Gsk3_Lifr
|
1063.55576038749
|
9.47
|
|
13
|
90
|
Bmp4r
|
Erk
|
1.00643342523252
|
964.022333976477
|
19
|
99.534
|
2
|
0
|
0
|
Bmp4r_Erk
|
1063.55633397648
|
9.36
|
|
14
|
27
|
Actr
|
Erk
|
-0.763289910081632
|
964.487926033674
|
18
|
99.068
|
1
|
0
|
0
|
Actr_Erk
|
1063.55592603367
|
9.31
|
|
15
|
34
|
Actr
|
Mek
|
-0.150168259323638
|
966.972716750091
|
18
|
96.583
|
1
|
0
|
0
|
Actr_Mek
|
1063.55571675009
|
9.08
|
|
16
|
37
|
Actr
|
Raf
|
-0.150168259323638
|
966.972716750091
|
18
|
96.583
|
1
|
0
|
0
|
Actr_Raf
|
1063.55571675009
|
9.08
|
|
17
|
38
|
Actr
|
Ras
|
-0.150168259323638
|
966.972716750091
|
18
|
96.583
|
1
|
0
|
0
|
Actr_Ras
|
1063.55571675009
|
9.08
|
|
18
|
178
|
Gsk3
|
Igfr
|
1.30183596917892
|
970.633324505165
|
19
|
92.923
|
2
|
0
|
0
|
Gsk3_Igfr
|
1063.55632450516
|
8.74
|
|
19
|
171
|
Gsk3
|
Akt
|
0.402280553698581
|
975.233547947986
|
19
|
88.322
|
2
|
0
|
0
|
Gsk3_Akt
|
1063.55554794799
|
8.3
|
|
20
|
183
|
Gsk3
|
Pi3k
|
27.7393642323468
|
975.296728351085
|
19
|
88.259
|
2
|
0
|
0
|
Gsk3_Pi3k
|
1063.55572835109
|
8.3
|
Intersection List
|
|
Link
|
Res_delta_XX
|
adj_pval_XX
|
Perc_Res_delta_XX
|
Res_delta_XO
|
adj_pval_XO
|
Perc_Res_delta_XO
|
Total_DelResidual
|
Tot_Percentage_DelResidual
|
|
1
|
Gsk3_Igfr
|
543.189
|
0
|
35.85
|
92.923
|
0
|
8.74
|
636.112
|
44.59
|
|
2
|
Gsk3_Akt
|
534.247
|
0
|
35.26
|
88.322
|
0
|
8.3
|
622.569
|
43.56
|
|
3
|
Gsk3_Pi3k
|
533.897
|
0
|
35.24
|
88.259
|
0
|
8.3
|
622.156
|
43.54
|
|
4
|
Gsk3_Fgfr
|
472.011
|
0
|
31.16
|
62.94
|
0
|
5.92
|
534.951
|
37.08
|
|
5
|
Gsk3_Jak
|
328.997
|
0
|
21.72
|
100.675
|
0
|
9.47
|
429.672
|
31.19
|
|
6
|
Gsk3_Lifr
|
328.997
|
0
|
21.72
|
100.675
|
0
|
9.47
|
429.672
|
31.19
|
|
29
|
Erk_Raf
|
40.028
|
0
|
2.64
|
247.924
|
0
|
23.31
|
287.952
|
25.95
|
|
30
|
Erk_Mek
|
40.028
|
0
|
2.64
|
247.924
|
0
|
23.31
|
287.952
|
25.95
|
|
31
|
Mek_Ras
|
40.028
|
0
|
2.64
|
247.924
|
0
|
23.31
|
287.952
|
25.95
|
|
32
|
Mek_Raf
|
40.028
|
0
|
2.64
|
247.924
|
0
|
23.31
|
287.952
|
25.95
|
|
33
|
Erk_Ras
|
40.028
|
0
|
2.64
|
247.924
|
0
|
23.31
|
287.952
|
25.95
|
|
7
|
Bmp4r_Fgfr
|
135.709
|
0
|
8.96
|
109.805
|
0
|
10.32
|
245.514
|
19.28
|
|
10
|
Bmp4r_Erk
|
105.121
|
0
|
6.94
|
99.534
|
0
|
9.36
|
204.655
|
16.3
|
|
8
|
Bmp4r_Lifr
|
109.602
|
0
|
7.23
|
85.461
|
0
|
8.04
|
195.063
|
15.27
|
|
9
|
Bmp4r_Jak
|
109.602
|
0
|
7.23
|
85.461
|
0
|
8.04
|
195.063
|
15.27
|
|
12
|
Bmp4r_Mek
|
82.474
|
0
|
5.44
|
101.397
|
0
|
9.53
|
183.871
|
14.97
|
|
13
|
Bmp4r_Raf
|
82.474
|
0
|
5.44
|
101.397
|
0
|
9.53
|
183.871
|
14.97
|
|
14
|
Bmp4r_Ras
|
82.474
|
0
|
5.44
|
101.397
|
0
|
9.53
|
183.871
|
14.97
|
|
11
|
Actr_Erk
|
83.948
|
0
|
5.54
|
99.068
|
0
|
9.31
|
183.016
|
14.85
|
|
16
|
Actr_Fgfr
|
78.401
|
0
|
5.17
|
102.67
|
0
|
9.65
|
181.071
|
14.82
|
LA2
XX : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
92
|
Bmp4r
|
Fgfr
|
100.000000000003
|
841.461666755043
|
21
|
129.337
|
2
|
0
|
0
|
Bmp4r_Fgfr
|
970.798666755043
|
13.32
|
|
2
|
90
|
Bmp4r
|
Erk
|
10.0000192017944
|
866.760153279043
|
21
|
104.038
|
2
|
0
|
0
|
Bmp4r_Erk
|
970.798153279043
|
10.72
|
|
3
|
95
|
Bmp4r
|
Jak
|
10.0001269820917
|
879.28557415186
|
21
|
91.513
|
2
|
0
|
0
|
Bmp4r_Jak
|
970.79857415186
|
9.43
|
|
4
|
96
|
Bmp4r
|
Lifr
|
214.317017758443
|
883.773260598781
|
21
|
87.025
|
2
|
0
|
0
|
Bmp4r_Lifr
|
970.798260598781
|
8.96
|
|
5
|
97
|
Bmp4r
|
Mek
|
1.0052953446443
|
889.238103252294
|
21
|
81.56
|
2
|
0
|
0
|
Bmp4r_Mek
|
970.798103252294
|
8.4
|
|
6
|
100
|
Bmp4r
|
Raf
|
1.0052953446443
|
889.238103252294
|
21
|
81.56
|
2
|
0
|
0
|
Bmp4r_Raf
|
970.798103252294
|
8.4
|
|
7
|
101
|
Bmp4r
|
Ras
|
1.0052953446443
|
889.238103252294
|
21
|
81.56
|
2
|
0
|
0
|
Bmp4r_Ras
|
970.798103252294
|
8.4
|
|
8
|
27
|
Actr
|
Erk
|
-0.327920234741696
|
899.875257200335
|
20
|
70.923
|
1
|
0
|
0
|
Actr_Erk
|
970.798257200335
|
7.31
|
|
9
|
220
|
Jak
|
Igfr
|
5.55539436656802e-05
|
901.522264003501
|
20
|
69.276
|
1
|
1.11022302462516e-16
|
0
|
Jak_Igfr
|
970.798264003501
|
7.14
|
|
10
|
219
|
Jak
|
Gsk3
|
2.62365545377848e-05
|
903.256424772377
|
20
|
67.542
|
1
|
2.22044604925031e-16
|
0
|
Jak_Gsk3
|
970.798424772377
|
6.96
|
|
11
|
213
|
Jak
|
Akt
|
7.21679806108667e-05
|
903.376234376356
|
20
|
67.422
|
1
|
2.22044604925031e-16
|
0
|
Jak_Akt
|
970.798234376356
|
6.95
|
|
12
|
225
|
Jak
|
Pi3k
|
3.34763735789056e-06
|
903.440683415853
|
20
|
67.358
|
1
|
2.22044604925031e-16
|
0
|
Jak_Pi3k
|
970.798683415853
|
6.94
|
|
13
|
34
|
Actr
|
Mek
|
-0.143655120450202
|
903.646874708811
|
20
|
67.152
|
1
|
2.22044604925031e-16
|
0
|
Actr_Mek
|
970.798874708811
|
6.92
|
|
14
|
37
|
Actr
|
Raf
|
-0.143655120450202
|
903.646874708811
|
20
|
67.152
|
1
|
2.22044604925031e-16
|
0
|
Actr_Raf
|
970.798874708811
|
6.92
|
|
15
|
38
|
Actr
|
Ras
|
-0.143655120450202
|
903.646874708811
|
20
|
67.152
|
1
|
2.22044604925031e-16
|
0
|
Actr_Ras
|
970.798874708811
|
6.92
|
|
16
|
223
|
Jak
|
Mek
|
-0.113535332475045
|
910.700258950734
|
20
|
60.098
|
1
|
8.99280649946377e-15
|
0
|
Jak_Mek
|
970.798258950734
|
6.19
|
|
17
|
227
|
Jak
|
Ras
|
-0.113451591250465
|
910.750797128889
|
20
|
60.048
|
1
|
9.2148511043888e-15
|
0
|
Jak_Ras
|
970.798797128889
|
6.19
|
|
18
|
226
|
Jak
|
Raf
|
-0.113451557015329
|
910.750832177611
|
20
|
60.048
|
1
|
9.2148511043888e-15
|
0
|
Jak_Raf
|
970.798832177611
|
6.19
|
|
19
|
29
|
Actr
|
Fgfr
|
-0.0996376218902906
|
916.8321693499
|
20
|
53.966
|
1
|
2.03947969623641e-13
|
0
|
Actr_Fgfr
|
970.7981693499
|
5.56
|
|
20
|
86
|
Bmp4r
|
Actr
|
100
|
925.364224509752
|
21
|
45.434
|
2
|
1.36166189435016e-10
|
0
|
Bmp4r_Actr
|
970.798224509752
|
4.68
|
XO : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
92
|
Bmp4r
|
Fgfr
|
100.000000000769
|
869.218810406832
|
21
|
101.413
|
2
|
0
|
0
|
Bmp4r_Fgfr
|
970.631810406832
|
10.45
|
|
2
|
97
|
Bmp4r
|
Mek
|
100.000000005133
|
871.46389835036
|
21
|
99.168
|
2
|
0
|
0
|
Bmp4r_Mek
|
970.63189835036
|
10.22
|
|
3
|
100
|
Bmp4r
|
Raf
|
100.000000005133
|
871.46389835036
|
21
|
99.168
|
2
|
0
|
0
|
Bmp4r_Raf
|
970.63189835036
|
10.22
|
|
4
|
101
|
Bmp4r
|
Ras
|
100.000000005133
|
871.46389835036
|
21
|
99.168
|
2
|
0
|
0
|
Bmp4r_Ras
|
970.63189835036
|
10.22
|
|
5
|
90
|
Bmp4r
|
Erk
|
100.000000093328
|
871.627560561552
|
21
|
99.004
|
2
|
0
|
0
|
Bmp4r_Erk
|
970.631560561552
|
10.2
|
|
6
|
27
|
Actr
|
Erk
|
-0.754763746009187
|
872.382026119069
|
20
|
98.25
|
1
|
0
|
0
|
Actr_Erk
|
970.632026119069
|
10.12
|
|
7
|
34
|
Actr
|
Mek
|
-0.152158078351239
|
875.399966538021
|
20
|
95.232
|
1
|
0
|
0
|
Actr_Mek
|
970.631966538021
|
9.81
|
|
8
|
37
|
Actr
|
Raf
|
-0.152158078351239
|
875.399966538021
|
20
|
95.232
|
1
|
0
|
0
|
Actr_Raf
|
970.631966538021
|
9.81
|
|
9
|
38
|
Actr
|
Ras
|
-0.152158078351239
|
875.399966538021
|
20
|
95.232
|
1
|
0
|
0
|
Actr_Ras
|
970.631966538021
|
9.81
|
|
10
|
29
|
Actr
|
Fgfr
|
-0.109752810948281
|
877.033681514489
|
20
|
93.598
|
1
|
0
|
0
|
Actr_Fgfr
|
970.631681514489
|
9.64
|
|
11
|
96
|
Bmp4r
|
Lifr
|
146.293823633502
|
890.206270302285
|
21
|
80.425
|
2
|
0
|
0
|
Bmp4r_Lifr
|
970.631270302285
|
8.29
|
|
12
|
95
|
Bmp4r
|
Jak
|
100.000000025193
|
893.519609105346
|
21
|
77.112
|
2
|
0
|
0
|
Bmp4r_Jak
|
970.631609105346
|
7.94
|
|
13
|
260
|
Mek
|
Fgfr
|
-3.92548662162183
|
916.678497099128
|
20
|
53.953
|
1
|
2.05280237253191e-13
|
0
|
Mek_Fgfr
|
970.631497099128
|
5.56
|
|
14
|
113
|
Erk
|
Fgfr
|
-1.05152055649687
|
916.678503870721
|
20
|
53.953
|
1
|
2.05280237253191e-13
|
0
|
Erk_Fgfr
|
970.631503870721
|
5.56
|
|
15
|
32
|
Actr
|
Jak
|
-3.64697909965899
|
918.840379685867
|
20
|
51.791
|
1
|
6.17284001691587e-13
|
0
|
Actr_Jak
|
970.631379685867
|
5.34
|
|
16
|
223
|
Jak
|
Mek
|
-0.679597168394505
|
919.385339278145
|
20
|
51.246
|
1
|
8.14792677772402e-13
|
0
|
Jak_Mek
|
970.631339278145
|
5.28
|
|
17
|
226
|
Jak
|
Raf
|
-0.679920915415589
|
919.387144134026
|
20
|
51.244
|
1
|
8.15458811587177e-13
|
0
|
Jak_Raf
|
970.631144134026
|
5.28
|
|
18
|
227
|
Jak
|
Ras
|
-0.679623805977004
|
919.388453030054
|
20
|
51.243
|
1
|
8.1601392309949e-13
|
0
|
Jak_Ras
|
970.631453030054
|
5.28
|
|
19
|
200
|
Igfr
|
Jak
|
0.607152559111106
|
924.915321563123
|
20
|
45.716
|
1
|
1.36680666784628e-11
|
0
|
Igfr_Jak
|
970.631321563123
|
4.71
|
|
20
|
201
|
Igfr
|
Lifr
|
0.607161455369962
|
924.915321756189
|
20
|
45.716
|
1
|
1.36680666784628e-11
|
0
|
Igfr_Lifr
|
970.631321756189
|
4.71
|
Intersection List
|
|
Link
|
Res_delta_XX
|
adj_pval_XX
|
Perc_Res_delta_XX
|
Res_delta_XO
|
adj_pval_XO
|
Perc_Res_delta_XO
|
Total_DelResidual
|
Tot_Percentage_DelResidual
|
|
1
|
Bmp4r_Fgfr
|
129.337
|
0
|
13.32
|
101.413
|
0
|
10.45
|
230.75
|
23.77
|
|
2
|
Bmp4r_Erk
|
104.038
|
0
|
10.72
|
99.004
|
0
|
10.2
|
203.042
|
20.92
|
|
5
|
Bmp4r_Mek
|
81.56
|
0
|
8.4
|
99.168
|
0
|
10.22
|
180.728
|
18.62
|
|
6
|
Bmp4r_Raf
|
81.56
|
0
|
8.4
|
99.168
|
0
|
10.22
|
180.728
|
18.62
|
|
7
|
Bmp4r_Ras
|
81.56
|
0
|
8.4
|
99.168
|
0
|
10.22
|
180.728
|
18.62
|
|
8
|
Actr_Erk
|
70.923
|
0
|
7.31
|
98.25
|
0
|
10.12
|
169.173
|
17.43
|
|
3
|
Bmp4r_Jak
|
91.513
|
0
|
9.43
|
77.112
|
0
|
7.94
|
168.625
|
17.37
|
|
4
|
Bmp4r_Lifr
|
87.025
|
0
|
8.96
|
80.425
|
0
|
8.29
|
167.45
|
17.25
|
|
13
|
Actr_Mek
|
67.152
|
0
|
6.92
|
95.232
|
0
|
9.81
|
162.384
|
16.73
|
|
14
|
Actr_Raf
|
67.152
|
0
|
6.92
|
95.232
|
0
|
9.81
|
162.384
|
16.73
|
|
15
|
Actr_Ras
|
67.152
|
0
|
6.92
|
95.232
|
0
|
9.81
|
162.384
|
16.73
|
|
19
|
Actr_Fgfr
|
53.966
|
0
|
5.56
|
93.598
|
0
|
9.64
|
147.564
|
15.2
|
|
16
|
Jak_Mek
|
60.098
|
0
|
6.19
|
51.246
|
0
|
5.28
|
111.344
|
11.47
|
|
17
|
Jak_Ras
|
60.048
|
0
|
6.19
|
51.243
|
0
|
5.28
|
111.291
|
11.47
|
|
18
|
Jak_Raf
|
60.048
|
0
|
6.19
|
51.244
|
0
|
5.28
|
111.292
|
11.47
|
|
9
|
Jak_Igfr
|
69.276
|
0
|
7.14
|
31.196
|
0
|
3.21
|
100.472
|
10.35
|
|
10
|
Jak_Gsk3
|
67.542
|
0
|
6.96
|
31.252
|
0
|
3.22
|
98.794
|
10.18
|
|
12
|
Jak_Pi3k
|
67.358
|
0
|
6.94
|
31.061
|
0
|
3.2
|
98.419
|
10.14
|
|
11
|
Jak_Akt
|
67.422
|
0
|
6.95
|
24.381
|
0
|
2.51
|
91.803
|
9.46
|
|
29
|
Actr_Jak
|
25.399
|
0
|
2.62
|
51.791
|
0
|
5.34
|
77.19
|
7.96
|
LA3
XX : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
213
|
Jak
|
Akt
|
0.000559101694508571
|
776.613258315932
|
22
|
62.177
|
1
|
3.10862446895044e-15
|
0
|
Jak_Akt
|
838.790258315932
|
7.41
|
|
2
|
225
|
Jak
|
Pi3k
|
8.97904410870197e-05
|
778.167767008921
|
22
|
60.622
|
1
|
6.88338275267597e-15
|
0
|
Jak_Pi3k
|
838.789767008921
|
7.23
|
|
3
|
226
|
Jak
|
Raf
|
-3.17320997476433
|
796.125380312149
|
22
|
42.665
|
1
|
6.49684750442248e-11
|
0
|
Jak_Raf
|
838.790380312149
|
5.09
|
|
4
|
223
|
Jak
|
Mek
|
-3.21824554283048
|
796.307860112286
|
22
|
42.482
|
1
|
7.13212822134324e-11
|
0
|
Jak_Mek
|
838.789860112286
|
5.06
|
|
5
|
227
|
Jak
|
Ras
|
-3.24588645068019
|
796.497908448933
|
22
|
42.292
|
1
|
7.8599460273665e-11
|
0
|
Jak_Ras
|
838.789908448933
|
5.04
|
|
6
|
103
|
Bmp4r
|
Smad2
|
100.02186644193
|
797.416938400438
|
22
|
41.373
|
1
|
1.25762289471254e-10
|
0
|
Bmp4r_Smad2
|
838.789938400438
|
4.93
|
|
7
|
86
|
Bmp4r
|
Actr
|
100.010657724698
|
797.452728577297
|
22
|
41.338
|
1
|
1.28086097284097e-10
|
0
|
Bmp4r_Actr
|
838.790728577297
|
4.93
|
|
8
|
27
|
Actr
|
Erk
|
-0.327920237439189
|
798.210046345649
|
22
|
40.58
|
1
|
1.88708271231519e-10
|
0
|
Actr_Erk
|
838.790046345649
|
4.84
|
|
9
|
118
|
Erk
|
Mek
|
-0.0986955651077006
|
801.650786718166
|
22
|
37.139
|
1
|
1.09975040185617e-09
|
0
|
Erk_Mek
|
838.789786718166
|
4.43
|
|
10
|
122
|
Erk
|
Ras
|
-0.0986955651090815
|
801.650787921435
|
22
|
37.139
|
1
|
1.09975106798998e-09
|
0
|
Erk_Ras
|
838.789787921435
|
4.43
|
|
11
|
121
|
Erk
|
Raf
|
-0.0986955651101688
|
801.650787967443
|
22
|
37.139
|
1
|
1.09975106798998e-09
|
0
|
Erk_Raf
|
838.789787967443
|
4.43
|
|
12
|
220
|
Jak
|
Igfr
|
8.04755410748596e-06
|
803.218989797017
|
22
|
35.571
|
1
|
2.45887887828644e-09
|
0
|
Jak_Igfr
|
838.789989797017
|
4.24
|
|
13
|
219
|
Jak
|
Gsk3
|
1.8976668905807e-06
|
804.236849232934
|
22
|
34.553
|
1
|
4.14715040086833e-09
|
0
|
Jak_Gsk3
|
838.789849232934
|
4.12
|
|
14
|
296
|
Pi3k
|
Actr
|
0.0799847924035548
|
805.648274322902
|
22
|
33.142
|
1
|
8.56689130745991e-09
|
0
|
Pi3k_Actr
|
838.790274322902
|
3.95
|
|
15
|
313
|
Pi3k
|
Smad2
|
0.0799847925091786
|
805.648274330931
|
22
|
33.142
|
1
|
8.56689130745991e-09
|
0
|
Pi3k_Smad2
|
838.790274330931
|
3.95
|
|
16
|
44
|
Akt
|
Actr
|
0.114956474981868
|
805.682679213556
|
22
|
33.108
|
1
|
8.71982563932505e-09
|
0
|
Akt_Actr
|
838.790679213556
|
3.95
|
|
17
|
61
|
Akt
|
Smad2
|
0.114956463482465
|
805.682680922324
|
22
|
33.108
|
1
|
8.71983329986392e-09
|
0
|
Akt_Smad2
|
838.790680922324
|
3.95
|
|
18
|
439
|
mTor
|
Smad2
|
0.506699766699231
|
805.710502414969
|
22
|
33.08
|
1
|
8.84550099833348e-09
|
0
|
mTor_Smad2
|
838.790502414969
|
3.94
|
|
19
|
422
|
mTor
|
Actr
|
0.506699424060749
|
805.710776705229
|
22
|
33.079
|
1
|
8.84674900003546e-09
|
0
|
mTor_Actr
|
838.789776705229
|
3.94
|
|
20
|
208
|
Igfr
|
Smad2
|
0.248919176116332
|
805.745289414332
|
22
|
33.045
|
1
|
9.00518659641136e-09
|
0
|
Igfr_Smad2
|
838.790289414332
|
3.94
|
XO : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
268
|
Mek
|
Raf
|
-6.48420744953439
|
611.484728447621
|
22
|
255.595
|
1
|
0
|
0
|
Mek_Raf
|
867.079728447621
|
29.48
|
|
2
|
269
|
Mek
|
Ras
|
-6.48503235451705
|
611.486413053196
|
22
|
255.594
|
1
|
0
|
0
|
Mek_Ras
|
867.080413053196
|
29.48
|
|
3
|
122
|
Erk
|
Ras
|
-1.42993730891105
|
611.600929146642
|
22
|
255.479
|
1
|
0
|
0
|
Erk_Ras
|
867.079929146642
|
29.46
|
|
4
|
118
|
Erk
|
Mek
|
-1.42955753822242
|
611.628079213488
|
22
|
255.452
|
1
|
0
|
0
|
Erk_Mek
|
867.080079213488
|
29.46
|
|
5
|
121
|
Erk
|
Raf
|
-1.42912374969748
|
611.673124799125
|
22
|
255.407
|
1
|
0
|
0
|
Erk_Raf
|
867.080124799125
|
29.46
|
|
6
|
103
|
Bmp4r
|
Smad2
|
0.875965322102496
|
785.739608677576
|
22
|
81.341
|
1
|
0
|
0
|
Bmp4r_Smad2
|
867.080608677576
|
9.38
|
|
7
|
86
|
Bmp4r
|
Actr
|
0.876416426590895
|
785.740483861214
|
22
|
81.34
|
1
|
0
|
0
|
Bmp4r_Actr
|
867.080483861214
|
9.38
|
|
8
|
149
|
Fgfr
|
Actr
|
0.970685060228157
|
800.239457835563
|
22
|
66.841
|
1
|
3.33066907387547e-16
|
0
|
Fgfr_Actr
|
867.080457835563
|
7.71
|
|
9
|
166
|
Fgfr
|
Smad2
|
0.970685071593034
|
800.239457957286
|
22
|
66.841
|
1
|
3.33066907387547e-16
|
0
|
Fgfr_Smad2
|
867.080457957286
|
7.71
|
|
10
|
355
|
Ras
|
Smad2
|
0.887689724088292
|
800.259729677718
|
22
|
66.82
|
1
|
3.33066907387547e-16
|
0
|
Ras_Smad2
|
867.079729677718
|
7.71
|
|
11
|
317
|
Raf
|
Actr
|
0.887689712593608
|
800.259729708413
|
22
|
66.82
|
1
|
3.33066907387547e-16
|
0
|
Raf_Actr
|
867.079729708413
|
7.71
|
|
12
|
334
|
Raf
|
Smad2
|
0.887689699306619
|
800.259729744808
|
22
|
66.82
|
1
|
3.33066907387547e-16
|
0
|
Raf_Smad2
|
867.079729744808
|
7.71
|
|
13
|
338
|
Ras
|
Actr
|
0.887689698278604
|
800.259729746685
|
22
|
66.82
|
1
|
3.33066907387547e-16
|
0
|
Ras_Actr
|
867.079729746685
|
7.71
|
|
14
|
219
|
Jak
|
Gsk3
|
0.0954023991913973
|
807.47789398697
|
22
|
59.602
|
1
|
1.16573417585641e-14
|
0
|
Jak_Gsk3
|
867.07989398697
|
6.87
|
|
15
|
113
|
Erk
|
Fgfr
|
-1.5175149811288
|
807.595214138194
|
22
|
59.485
|
1
|
1.23234755733392e-14
|
0
|
Erk_Fgfr
|
867.080214138194
|
6.86
|
|
16
|
260
|
Mek
|
Fgfr
|
-5.97670693702218
|
807.595214433142
|
22
|
59.485
|
1
|
1.23234755733392e-14
|
0
|
Mek_Fgfr
|
867.080214433142
|
6.86
|
|
17
|
110
|
Erk
|
Bmp4r
|
-0.000225633437653167
|
807.599122894852
|
22
|
59.481
|
1
|
1.23234755733392e-14
|
0
|
Erk_Bmp4r
|
867.080122894852
|
6.86
|
|
18
|
107
|
Erk
|
Actr
|
0.126656810527513
|
807.796915131121
|
22
|
59.283
|
1
|
1.36557432028894e-14
|
0
|
Erk_Actr
|
867.079915131121
|
6.84
|
|
19
|
124
|
Erk
|
Smad2
|
0.126651673457868
|
807.800025300678
|
22
|
59.28
|
1
|
1.36557432028894e-14
|
0
|
Erk_Smad2
|
867.080025300678
|
6.84
|
|
20
|
271
|
Mek
|
Smad2
|
0.583506936563152
|
807.833207759399
|
22
|
59.247
|
1
|
1.38777878078145e-14
|
0
|
Mek_Smad2
|
867.080207759399
|
6.83
|
Intersection List
|
|
Link
|
Res_delta_XX
|
adj_pval_XX
|
Perc_Res_delta_XX
|
Res_delta_XO
|
adj_pval_XO
|
Perc_Res_delta_XO
|
Total_DelResidual
|
Tot_Percentage_DelResidual
|
|
9
|
Erk_Mek
|
37.139
|
0
|
4.43
|
255.452
|
0
|
29.46
|
292.591
|
33.89
|
|
10
|
Erk_Ras
|
37.139
|
0
|
4.43
|
255.479
|
0
|
29.46
|
292.618
|
33.89
|
|
11
|
Erk_Raf
|
37.139
|
0
|
4.43
|
255.407
|
0
|
29.46
|
292.546
|
33.89
|
|
6
|
Bmp4r_Smad2
|
41.373
|
0
|
4.93
|
81.341
|
0
|
9.38
|
122.714
|
14.31
|
|
7
|
Bmp4r_Actr
|
41.338
|
0
|
4.93
|
81.34
|
0
|
9.38
|
122.678
|
14.31
|
|
1
|
Jak_Akt
|
62.177
|
0
|
7.41
|
56.91
|
0
|
6.56
|
119.087
|
13.97
|
|
2
|
Jak_Pi3k
|
60.622
|
0
|
7.23
|
56.933
|
0
|
6.57
|
117.555
|
13.8
|
|
3
|
Jak_Raf
|
42.665
|
0
|
5.09
|
54.53
|
0
|
6.29
|
97.195
|
11.38
|
|
4
|
Jak_Mek
|
42.482
|
0
|
5.06
|
54.528
|
0
|
6.29
|
97.01
|
11.35
|
|
5
|
Jak_Ras
|
42.292
|
0
|
5.04
|
54.53
|
0
|
6.29
|
96.822
|
11.33
|
|
13
|
Jak_Gsk3
|
34.553
|
0
|
4.12
|
59.602
|
0
|
6.87
|
94.155
|
10.99
|
|
12
|
Jak_Igfr
|
35.571
|
0
|
4.24
|
56.91
|
0
|
6.56
|
92.481
|
10.8
|
|
28
|
Fgfr_Actr
|
23.709
|
0
|
2.83
|
66.841
|
0
|
7.71
|
90.55
|
10.54
|
|
29
|
Fgfr_Smad2
|
23.709
|
0
|
2.83
|
66.841
|
0
|
7.71
|
90.55
|
10.54
|
|
8
|
Actr_Erk
|
40.58
|
0
|
4.84
|
49.135
|
0
|
5.67
|
89.715
|
10.51
|
|
16
|
Akt_Actr
|
33.108
|
0
|
3.95
|
45.705
|
0
|
5.27
|
78.813
|
9.22
|
|
17
|
Akt_Smad2
|
33.108
|
0
|
3.95
|
45.706
|
0
|
5.27
|
78.814
|
9.22
|
|
20
|
Igfr_Smad2
|
33.045
|
0
|
3.94
|
45.665
|
0
|
5.27
|
78.71
|
9.21
|
|
21
|
Igfr_Actr
|
33.039
|
0
|
3.94
|
45.665
|
0
|
5.27
|
78.704
|
9.21
|
|
14
|
Pi3k_Actr
|
33.142
|
0
|
3.95
|
45.547
|
0
|
5.25
|
78.689
|
9.2
|
LA4
XX : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
213
|
Jak
|
Akt
|
0.000707406177266371
|
737.960495916585
|
23
|
60.351
|
1
|
7.99360577730113e-15
|
0
|
Jak_Akt
|
798.311495916585
|
7.56
|
|
2
|
220
|
Jak
|
Igfr
|
5.03600959182369e-05
|
739.346387831751
|
23
|
58.965
|
1
|
1.60982338570648e-14
|
0
|
Jak_Igfr
|
798.311387831751
|
7.39
|
|
3
|
219
|
Jak
|
Gsk3
|
8.91364101617684e-05
|
739.36887470925
|
23
|
58.942
|
1
|
1.62092561595273e-14
|
0
|
Jak_Gsk3
|
798.31087470925
|
7.38
|
|
4
|
225
|
Jak
|
Pi3k
|
0.000323749018200995
|
739.465644562853
|
23
|
58.845
|
1
|
1.70974345792274e-14
|
0
|
Jak_Pi3k
|
798.310644562853
|
7.37
|
|
5
|
86
|
Bmp4r
|
Actr
|
0.1
|
760.705112213975
|
23
|
37.606
|
1
|
8.65806981664718e-10
|
0
|
Bmp4r_Actr
|
798.311112213975
|
4.71
|
|
6
|
103
|
Bmp4r
|
Smad2
|
0.1
|
760.705112213975
|
23
|
37.606
|
1
|
8.65806981664718e-10
|
0
|
Bmp4r_Smad2
|
798.311112213975
|
4.71
|
|
7
|
27
|
Actr
|
Erk
|
-0.327920237444485
|
761.52862579633
|
23
|
36.782
|
1
|
1.32075872461002e-09
|
0
|
Actr_Erk
|
798.31062579633
|
4.61
|
|
8
|
34
|
Actr
|
Mek
|
-0.147675991438342
|
763.080355755634
|
23
|
35.231
|
1
|
2.92871626950131e-09
|
0
|
Actr_Mek
|
798.311355755634
|
4.41
|
|
9
|
37
|
Actr
|
Raf
|
-0.147675991438342
|
763.080355755634
|
23
|
35.231
|
1
|
2.92871626950131e-09
|
0
|
Actr_Raf
|
798.311355755634
|
4.41
|
|
10
|
38
|
Actr
|
Ras
|
-0.147675991438342
|
763.080355755634
|
23
|
35.231
|
1
|
2.92871626950131e-09
|
0
|
Actr_Ras
|
798.311355755634
|
4.41
|
|
11
|
313
|
Pi3k
|
Smad2
|
0.0731215380340072
|
765.019323945664
|
23
|
33.292
|
1
|
7.93195686910053e-09
|
0
|
Pi3k_Smad2
|
798.311323945664
|
4.17
|
|
12
|
296
|
Pi3k
|
Actr
|
0.0731215380385857
|
765.019323952992
|
23
|
33.292
|
1
|
7.93195698012283e-09
|
0
|
Pi3k_Actr
|
798.311323952992
|
4.17
|
|
13
|
208
|
Igfr
|
Smad2
|
0.241198705130075
|
765.079332485809
|
23
|
33.232
|
1
|
8.18054357587528e-09
|
0
|
Igfr_Smad2
|
798.311332485809
|
4.16
|
|
14
|
191
|
Igfr
|
Actr
|
0.241198772831739
|
765.079352853858
|
23
|
33.232
|
1
|
8.18062928509278e-09
|
0
|
Igfr_Actr
|
798.311352853858
|
4.16
|
|
15
|
61
|
Akt
|
Smad2
|
0.115582218277731
|
765.081920020915
|
23
|
33.229
|
1
|
8.19143630703678e-09
|
0
|
Akt_Smad2
|
798.310920020915
|
4.16
|
|
16
|
44
|
Akt
|
Actr
|
0.11554890986298
|
765.083602077782
|
23
|
33.227
|
1
|
8.19852497002671e-09
|
0
|
Akt_Actr
|
798.310602077782
|
4.16
|
|
17
|
187
|
Gsk3
|
Smad2
|
0.247120865441656
|
765.124860320833
|
23
|
33.186
|
1
|
8.37433644651497e-09
|
0
|
Gsk3_Smad2
|
798.310860320833
|
4.16
|
|
18
|
170
|
Gsk3
|
Actr
|
0.246911867653975
|
765.131120793124
|
23
|
33.18
|
1
|
8.40134184443286e-09
|
0
|
Gsk3_Actr
|
798.311120793124
|
4.16
|
|
19
|
53
|
Akt
|
Jak
|
0.276120231261104
|
772.53993913228
|
23
|
25.771
|
1
|
3.8440010663443e-07
|
0
|
Akt_Jak
|
798.31093913228
|
3.23
|
|
20
|
305
|
Pi3k
|
Jak
|
0.176081368463955
|
772.553960374723
|
23
|
25.757
|
1
|
3.87202878093795e-07
|
0
|
Pi3k_Jak
|
798.310960374723
|
3.23
|
XO : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
86
|
Bmp4r
|
Actr
|
1
|
538.054691994744
|
23
|
73.427
|
1
|
0
|
0
|
Bmp4r_Actr
|
611.481691994744
|
12.01
|
|
2
|
103
|
Bmp4r
|
Smad2
|
1
|
538.054691994744
|
23
|
73.427
|
1
|
0
|
0
|
Bmp4r_Smad2
|
611.481691994744
|
12.01
|
|
3
|
338
|
Ras
|
Actr
|
0.972501250488619
|
545.487280932185
|
23
|
65.994
|
1
|
4.44089209850063e-16
|
0
|
Ras_Actr
|
611.481280932185
|
10.79
|
|
4
|
355
|
Ras
|
Smad2
|
0.972436848502515
|
545.489382476489
|
23
|
65.992
|
1
|
4.44089209850063e-16
|
0
|
Ras_Smad2
|
611.481382476489
|
10.79
|
|
5
|
219
|
Jak
|
Gsk3
|
0.097227252336912
|
547.331783332299
|
23
|
64.15
|
1
|
1.11022302462516e-15
|
0
|
Jak_Gsk3
|
611.481783332299
|
10.49
|
|
6
|
225
|
Jak
|
Pi3k
|
0.00814337884241785
|
550.116268160372
|
23
|
61.365
|
1
|
4.77395900588817e-15
|
0
|
Jak_Pi3k
|
611.481268160372
|
10.04
|
|
7
|
220
|
Jak
|
Igfr
|
0.00147940987131239
|
550.139649856149
|
23
|
61.342
|
1
|
4.77395900588817e-15
|
0
|
Jak_Igfr
|
611.481649856149
|
10.03
|
|
8
|
213
|
Jak
|
Akt
|
0.000326884318160387
|
550.170695575493
|
23
|
61.311
|
1
|
4.88498130835069e-15
|
0
|
Jak_Akt
|
611.481695575493
|
10.03
|
|
9
|
149
|
Fgfr
|
Actr
|
0.999999999999996
|
551.103681406195
|
23
|
60.378
|
1
|
7.88258347483861e-15
|
0
|
Fgfr_Actr
|
611.481681406195
|
9.87
|
|
10
|
166
|
Fgfr
|
Smad2
|
0.999999999999996
|
551.103681406195
|
23
|
60.378
|
1
|
7.88258347483861e-15
|
0
|
Fgfr_Smad2
|
611.481681406195
|
9.87
|
|
11
|
107
|
Erk
|
Actr
|
0.126706984182453
|
552.877015400509
|
23
|
58.604
|
1
|
1.93178806284777e-14
|
0
|
Erk_Actr
|
611.481015400509
|
9.58
|
|
12
|
124
|
Erk
|
Smad2
|
0.126697788192819
|
552.877929597554
|
23
|
58.603
|
1
|
1.93178806284777e-14
|
0
|
Erk_Smad2
|
611.480929597554
|
9.58
|
|
13
|
254
|
Mek
|
Actr
|
0.59438460540211
|
552.893586778656
|
23
|
58.588
|
1
|
1.94289029309402e-14
|
0
|
Mek_Actr
|
611.481586778656
|
9.58
|
|
14
|
271
|
Mek
|
Smad2
|
0.594390267384607
|
552.894447059316
|
23
|
58.587
|
1
|
1.94289029309402e-14
|
0
|
Mek_Smad2
|
611.481447059316
|
9.58
|
|
15
|
227
|
Jak
|
Ras
|
-4.20013840049262
|
553.491954053355
|
23
|
57.989
|
1
|
2.63122856836162e-14
|
0
|
Jak_Ras
|
611.480954053355
|
9.48
|
|
16
|
223
|
Jak
|
Mek
|
-4.13026330024292
|
553.624103730407
|
23
|
57.857
|
1
|
2.8199664825479e-14
|
0
|
Jak_Mek
|
611.481103730407
|
9.46
|
|
17
|
226
|
Jak
|
Raf
|
-4.05360082602932
|
553.771671777469
|
23
|
57.71
|
1
|
3.04201108747293e-14
|
0
|
Jak_Raf
|
611.481671777469
|
9.44
|
|
18
|
179
|
Gsk3
|
Jak
|
0.119656073842834
|
562.645430796745
|
23
|
48.836
|
1
|
2.78288503352542e-12
|
0
|
Gsk3_Jak
|
611.481430796745
|
7.99
|
|
19
|
180
|
Gsk3
|
Lifr
|
0.119656628383289
|
562.645433046035
|
23
|
48.836
|
1
|
2.78288503352542e-12
|
0
|
Gsk3_Lifr
|
611.481433046035
|
7.99
|
|
20
|
296
|
Pi3k
|
Actr
|
0.0388793995773065
|
566.197502392802
|
23
|
45.284
|
1
|
1.70445879632553e-11
|
0
|
Pi3k_Actr
|
611.481502392802
|
7.41
|
Intersection List
|
|
Link
|
Res_delta_XX
|
adj_pval_XX
|
Perc_Res_delta_XX
|
Res_delta_XO
|
adj_pval_XO
|
Perc_Res_delta_XO
|
Total_DelResidual
|
Tot_Percentage_DelResidual
|
|
3
|
Jak_Gsk3
|
58.942
|
0
|
7.38
|
64.15
|
0
|
10.49
|
123.092
|
17.87
|
|
1
|
Jak_Akt
|
60.351
|
0
|
7.56
|
61.311
|
0
|
10.03
|
121.662
|
17.59
|
|
2
|
Jak_Igfr
|
58.965
|
0
|
7.39
|
61.342
|
0
|
10.03
|
120.307
|
17.42
|
|
4
|
Jak_Pi3k
|
58.845
|
0
|
7.37
|
61.365
|
0
|
10.04
|
120.21
|
17.41
|
|
5
|
Bmp4r_Actr
|
37.606
|
0
|
4.71
|
73.427
|
0
|
12.01
|
111.033
|
16.72
|
|
6
|
Bmp4r_Smad2
|
37.606
|
0
|
4.71
|
73.427
|
0
|
12.01
|
111.033
|
16.72
|
|
27
|
Ras_Actr
|
22.461
|
0.001
|
2.81
|
65.994
|
0
|
10.79
|
88.455
|
13.6
|
|
28
|
Ras_Smad2
|
22.461
|
0.001
|
2.81
|
65.992
|
0
|
10.79
|
88.453
|
13.6
|
|
23
|
Fgfr_Actr
|
24.147
|
0
|
3.02
|
60.378
|
0
|
9.87
|
84.525
|
12.89
|
|
24
|
Fgfr_Smad2
|
24.147
|
0
|
3.02
|
60.378
|
0
|
9.87
|
84.525
|
12.89
|
|
7
|
Actr_Mek
|
35.231
|
0
|
4.41
|
44.814
|
0
|
7.33
|
80.045
|
11.74
|
|
8
|
Actr_Raf
|
35.231
|
0
|
4.41
|
44.814
|
0
|
7.33
|
80.045
|
11.74
|
|
9
|
Actr_Ras
|
35.231
|
0
|
4.41
|
44.814
|
0
|
7.33
|
80.045
|
11.74
|
|
10
|
Pi3k_Smad2
|
33.292
|
0
|
4.17
|
45.282
|
0
|
7.41
|
78.574
|
11.58
|
|
11
|
Pi3k_Actr
|
33.292
|
0
|
4.17
|
45.284
|
0
|
7.41
|
78.576
|
11.58
|
|
12
|
Igfr_Smad2
|
33.232
|
0
|
4.16
|
45.251
|
0
|
7.4
|
78.483
|
11.56
|
|
13
|
Igfr_Actr
|
33.232
|
0
|
4.16
|
45.251
|
0
|
7.4
|
78.483
|
11.56
|
|
14
|
Akt_Smad2
|
33.229
|
0
|
4.16
|
45.28
|
0
|
7.4
|
78.509
|
11.56
|
|
15
|
Akt_Actr
|
33.227
|
0
|
4.16
|
45.28
|
0
|
7.4
|
78.507
|
11.56
|
|
16
|
Gsk3_Smad2
|
33.186
|
0
|
4.16
|
45.178
|
0
|
7.39
|
78.364
|
11.55
|
LA5
XX : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
34
|
Actr
|
Mek
|
-0.169510536243249
|
691.497669974297
|
24
|
46.457
|
1
|
9.3647312127132e-12
|
0
|
Actr_Mek
|
737.954669974297
|
6.3
|
|
2
|
37
|
Actr
|
Raf
|
-0.169510524829761
|
691.497670173476
|
24
|
46.457
|
1
|
9.3647312127132e-12
|
0
|
Actr_Raf
|
737.954670173476
|
6.3
|
|
3
|
38
|
Actr
|
Ras
|
-0.169510524829761
|
691.497670173476
|
24
|
46.457
|
1
|
9.3647312127132e-12
|
0
|
Actr_Ras
|
737.954670173476
|
6.3
|
|
4
|
27
|
Actr
|
Erk
|
-0.329216993650508
|
692.07872455242
|
24
|
45.876
|
1
|
1.25978116827241e-11
|
0
|
Actr_Erk
|
737.95472455242
|
6.22
|
|
5
|
86
|
Bmp4r
|
Actr
|
0.1
|
692.718298841271
|
24
|
45.236
|
1
|
1.74623648874217e-11
|
0
|
Bmp4r_Actr
|
737.954298841271
|
6.13
|
|
6
|
103
|
Bmp4r
|
Smad2
|
0.1
|
692.718298841271
|
24
|
45.236
|
1
|
1.74623648874217e-11
|
0
|
Bmp4r_Smad2
|
737.954298841271
|
6.13
|
|
7
|
29
|
Actr
|
Fgfr
|
-0.931701344045143
|
698.398913256414
|
24
|
39.556
|
1
|
3.1881031148373e-10
|
0
|
Actr_Fgfr
|
737.954913256414
|
5.36
|
|
8
|
208
|
Igfr
|
Smad2
|
0.252182901106177
|
703.801214372991
|
24
|
34.154
|
1
|
5.09303343942946e-09
|
0
|
Igfr_Smad2
|
737.955214372991
|
4.63
|
|
9
|
191
|
Igfr
|
Actr
|
0.25201962503734
|
703.801382643909
|
24
|
34.153
|
1
|
5.09347386490333e-09
|
0
|
Igfr_Actr
|
737.954382643909
|
4.63
|
|
10
|
313
|
Pi3k
|
Smad2
|
0.30512095678214
|
703.822303571833
|
24
|
34.132
|
1
|
5.14852960264989e-09
|
0
|
Pi3k_Smad2
|
737.954303571833
|
4.63
|
|
11
|
296
|
Pi3k
|
Actr
|
0.30512095702263
|
703.822303599494
|
24
|
34.132
|
1
|
5.14852960264989e-09
|
0
|
Pi3k_Actr
|
737.954303599494
|
4.63
|
|
12
|
187
|
Gsk3
|
Smad2
|
0.253667914857315
|
703.846862678593
|
24
|
34.108
|
1
|
5.21392051755498e-09
|
0
|
Gsk3_Smad2
|
737.954862678593
|
4.62
|
|
13
|
170
|
Gsk3
|
Actr
|
0.253710860378536
|
703.847228684446
|
24
|
34.108
|
1
|
5.21490128857494e-09
|
0
|
Gsk3_Actr
|
737.955228684446
|
4.62
|
|
14
|
439
|
mTor
|
Smad2
|
0.513028961424221
|
703.894000572903
|
24
|
34.061
|
1
|
5.34176891608951e-09
|
0
|
mTor_Smad2
|
737.955000572903
|
4.62
|
|
15
|
422
|
mTor
|
Actr
|
0.513027303830231
|
703.894099130928
|
24
|
34.061
|
1
|
5.34203947744061e-09
|
0
|
mTor_Actr
|
737.955099130928
|
4.62
|
|
16
|
61
|
Akt
|
Smad2
|
0.117738990295091
|
703.913397121712
|
24
|
34.041
|
1
|
5.39528410836709e-09
|
0
|
Akt_Smad2
|
737.954397121712
|
4.61
|
|
17
|
44
|
Akt
|
Actr
|
0.117751598541854
|
703.914010526694
|
24
|
34.041
|
1
|
5.39698519208542e-09
|
0
|
Akt_Actr
|
737.955010526694
|
4.61
|
|
18
|
317
|
Raf
|
Actr
|
0.40403238554479
|
705.000526082368
|
24
|
32.954
|
1
|
9.43539935072124e-09
|
0
|
Raf_Actr
|
737.954526082368
|
4.47
|
|
19
|
334
|
Raf
|
Smad2
|
1
|
708.952730831816
|
24
|
29.002
|
1
|
7.23024873305889e-08
|
0
|
Raf_Smad2
|
737.954730831816
|
3.93
|
|
20
|
166
|
Fgfr
|
Smad2
|
0.252543285418482
|
708.979059442361
|
24
|
28.976
|
1
|
7.3291891000693e-08
|
0
|
Fgfr_Smad2
|
737.955059442361
|
3.93
|
XO : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
86
|
Bmp4r
|
Actr
|
1.34506065680717
|
465.989068796561
|
24
|
81.343
|
1
|
0
|
0
|
Bmp4r_Actr
|
547.332068796561
|
14.86
|
|
2
|
103
|
Bmp4r
|
Smad2
|
1.34504409171201
|
465.989068797419
|
24
|
81.343
|
1
|
0
|
0
|
Bmp4r_Smad2
|
547.332068797419
|
14.86
|
|
3
|
166
|
Fgfr
|
Smad2
|
0.787374824949833
|
487.061033975627
|
24
|
60.271
|
1
|
8.21565038222616e-15
|
0
|
Fgfr_Smad2
|
547.332033975627
|
11.01
|
|
4
|
338
|
Ras
|
Actr
|
0.787455359343572
|
487.061033993199
|
24
|
60.271
|
1
|
8.21565038222616e-15
|
0
|
Ras_Actr
|
547.332033993199
|
11.01
|
|
5
|
355
|
Ras
|
Smad2
|
0.787502733552122
|
487.061034044346
|
24
|
60.271
|
1
|
8.21565038222616e-15
|
0
|
Ras_Smad2
|
547.332034044346
|
11.01
|
|
6
|
149
|
Fgfr
|
Actr
|
0.787361722517166
|
487.061034176801
|
24
|
60.271
|
1
|
8.21565038222616e-15
|
0
|
Fgfr_Actr
|
547.332034176801
|
11.01
|
|
7
|
254
|
Mek
|
Actr
|
0.543845407260371
|
493.382475651737
|
24
|
53.949
|
1
|
2.05724326463042e-13
|
0
|
Mek_Actr
|
547.331475651737
|
9.86
|
|
8
|
271
|
Mek
|
Smad2
|
0.543845594194931
|
493.382475743574
|
24
|
53.949
|
1
|
2.05724326463042e-13
|
0
|
Mek_Smad2
|
547.331475743574
|
9.86
|
|
9
|
107
|
Erk
|
Actr
|
0.123251772849866
|
493.382475913176
|
24
|
53.949
|
1
|
2.05724326463042e-13
|
0
|
Erk_Actr
|
547.331475913176
|
9.86
|
|
10
|
124
|
Erk
|
Smad2
|
0.123252011763697
|
493.382475950772
|
24
|
53.949
|
1
|
2.05724326463042e-13
|
0
|
Erk_Smad2
|
547.331475950772
|
9.86
|
|
11
|
179
|
Gsk3
|
Jak
|
0.254057940252951
|
498.90101774214
|
24
|
48.431
|
1
|
3.42159633959227e-12
|
0
|
Gsk3_Jak
|
547.33201774214
|
8.85
|
|
12
|
180
|
Gsk3
|
Lifr
|
0.254068705210873
|
498.901018202538
|
24
|
48.431
|
1
|
3.42159633959227e-12
|
0
|
Gsk3_Lifr
|
547.332018202538
|
8.85
|
|
13
|
200
|
Igfr
|
Jak
|
0.39468277779385
|
502.069366179668
|
24
|
45.262
|
1
|
1.72324376990218e-11
|
0
|
Igfr_Jak
|
547.331366179668
|
8.27
|
|
14
|
201
|
Igfr
|
Lifr
|
0.394481641402181
|
502.06936628535
|
24
|
45.262
|
1
|
1.72324376990218e-11
|
0
|
Igfr_Lifr
|
547.33136628535
|
8.27
|
|
15
|
29
|
Actr
|
Fgfr
|
-0.0929454245928924
|
502.642865730224
|
24
|
44.689
|
1
|
2.30960806035796e-11
|
0
|
Actr_Fgfr
|
547.331865730224
|
8.16
|
|
16
|
26
|
Actr
|
Bmp4r
|
-0.000417518501707003
|
502.643828211024
|
24
|
44.688
|
1
|
2.31075159007332e-11
|
0
|
Actr_Bmp4r
|
547.331828211024
|
8.16
|
|
17
|
25
|
Actr
|
Bmp4
|
-0.000417633273419691
|
502.643828453475
|
24
|
44.688
|
1
|
2.31075159007332e-11
|
0
|
Actr_Bmp4
|
547.331828453475
|
8.16
|
|
18
|
34
|
Actr
|
Mek
|
-0.766280755915089
|
503.920691793538
|
24
|
43.411
|
1
|
4.43667325100705e-11
|
0
|
Actr_Mek
|
547.331691793538
|
7.93
|
|
19
|
37
|
Actr
|
Raf
|
-0.766280755915089
|
503.920691793538
|
24
|
43.411
|
1
|
4.43667325100705e-11
|
0
|
Actr_Raf
|
547.331691793538
|
7.93
|
|
20
|
38
|
Actr
|
Ras
|
-0.766280755915089
|
503.920691793538
|
24
|
43.411
|
1
|
4.43667325100705e-11
|
0
|
Actr_Ras
|
547.331691793538
|
7.93
|
Intersection List
|
|
Link
|
Res_delta_XX
|
adj_pval_XX
|
Perc_Res_delta_XX
|
Res_delta_XO
|
adj_pval_XO
|
Perc_Res_delta_XO
|
Total_DelResidual
|
Tot_Percentage_DelResidual
|
|
4
|
Bmp4r_Actr
|
45.236
|
0
|
6.13
|
81.343
|
0
|
14.86
|
126.579
|
20.99
|
|
5
|
Bmp4r_Smad2
|
45.236
|
0
|
6.13
|
81.343
|
0
|
14.86
|
126.579
|
20.99
|
|
17
|
Fgfr_Smad2
|
28.976
|
0
|
3.93
|
60.271
|
0
|
11.01
|
89.247
|
14.94
|
|
18
|
Fgfr_Actr
|
28.777
|
0
|
3.9
|
60.271
|
0
|
11.01
|
89.048
|
14.91
|
|
1
|
Actr_Mek
|
46.457
|
0
|
6.3
|
43.411
|
0
|
7.93
|
89.868
|
14.23
|
|
2
|
Actr_Raf
|
46.457
|
0
|
6.3
|
43.411
|
0
|
7.93
|
89.868
|
14.23
|
|
3
|
Actr_Ras
|
46.457
|
0
|
6.3
|
43.411
|
0
|
7.93
|
89.868
|
14.23
|
|
6
|
Actr_Fgfr
|
39.556
|
0
|
5.36
|
44.689
|
0
|
8.16
|
84.245
|
13.52
|
|
7
|
Igfr_Smad2
|
34.154
|
0
|
4.63
|
38.974
|
0
|
7.12
|
73.128
|
11.75
|
|
8
|
Igfr_Actr
|
34.153
|
0
|
4.63
|
38.974
|
0
|
7.12
|
73.127
|
11.75
|
|
11
|
Gsk3_Smad2
|
34.108
|
0
|
4.62
|
38.911
|
0
|
7.11
|
73.019
|
11.73
|
|
12
|
Gsk3_Actr
|
34.108
|
0
|
4.62
|
38.911
|
0
|
7.11
|
73.019
|
11.73
|
|
20
|
Igfr_Lifr
|
24.35
|
0
|
3.3
|
45.262
|
0
|
8.27
|
69.612
|
11.57
|
|
21
|
Igfr_Jak
|
24.312
|
0
|
3.29
|
45.262
|
0
|
8.27
|
69.574
|
11.56
|
|
9
|
Pi3k_Smad2
|
34.132
|
0
|
4.63
|
37.796
|
0
|
6.91
|
71.928
|
11.54
|
|
10
|
Pi3k_Actr
|
34.132
|
0
|
4.63
|
37.796
|
0
|
6.91
|
71.928
|
11.54
|
|
13
|
mTor_Smad2
|
34.061
|
0
|
4.62
|
37.796
|
0
|
6.91
|
71.857
|
11.53
|
|
14
|
mTor_Actr
|
34.061
|
0
|
4.62
|
37.796
|
0
|
6.91
|
71.857
|
11.53
|
|
15
|
Akt_Smad2
|
34.041
|
0
|
4.61
|
37.796
|
0
|
6.91
|
71.837
|
11.52
|
|
16
|
Akt_Actr
|
34.041
|
0
|
4.61
|
37.796
|
0
|
6.91
|
71.837
|
11.52
|
LA6
XX : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
27
|
Actr
|
Erk
|
-0.3764990238487
|
642.112873213278
|
25
|
49.77
|
1
|
1.72895031624876e-12
|
0
|
Actr_Erk
|
691.882873213278
|
7.19
|
|
2
|
26
|
Actr
|
Bmp4r
|
-0.114345956401805
|
651.432322957465
|
25
|
40.45
|
1
|
2.01689220880041e-10
|
0
|
Actr_Bmp4r
|
691.882322957465
|
5.85
|
|
3
|
34
|
Actr
|
Mek
|
-0.184466635341531
|
651.695610071583
|
25
|
40.187
|
1
|
2.30786167954022e-10
|
0
|
Actr_Mek
|
691.882610071583
|
5.81
|
|
4
|
37
|
Actr
|
Raf
|
-0.184466635341531
|
651.695610071583
|
25
|
40.187
|
1
|
2.30786167954022e-10
|
0
|
Actr_Raf
|
691.882610071583
|
5.81
|
|
5
|
38
|
Actr
|
Ras
|
-0.184466635341531
|
651.695610071583
|
25
|
40.187
|
1
|
2.30786167954022e-10
|
0
|
Actr_Ras
|
691.882610071583
|
5.81
|
|
6
|
29
|
Actr
|
Fgfr
|
-0.19305395874701
|
651.86148251821
|
25
|
40.021
|
1
|
2.51238807535969e-10
|
0
|
Actr_Fgfr
|
691.88248251821
|
5.78
|
|
7
|
194
|
Igfr
|
Bmp4r
|
9.52513344378078
|
660.382834653848
|
25
|
31.5
|
1
|
1.99469695205678e-08
|
0
|
Igfr_Bmp4r
|
691.882834653848
|
4.55
|
|
8
|
173
|
Gsk3
|
Bmp4r
|
8.35970405891355
|
662.907058780043
|
25
|
28.975
|
1
|
7.32999207997409e-08
|
0
|
Gsk3_Bmp4r
|
691.882058780043
|
4.19
|
|
9
|
25
|
Actr
|
Bmp4
|
-0.0464156641394266
|
663.78872868241
|
25
|
28.094
|
1
|
1.15574366854609e-07
|
0
|
Actr_Bmp4
|
691.88272868241
|
4.06
|
|
10
|
201
|
Igfr
|
Lifr
|
1.04830731184343
|
667.510464263871
|
25
|
24.372
|
1
|
7.94111451152268e-07
|
0
|
Igfr_Lifr
|
691.882464263871
|
3.52
|
|
11
|
54
|
Akt
|
Lifr
|
0.575162428124432
|
667.568175497793
|
25
|
24.314
|
1
|
8.18262327006991e-07
|
0
|
Akt_Lifr
|
691.882175497793
|
3.51
|
|
12
|
200
|
Igfr
|
Jak
|
1.96579482255861
|
667.587872687412
|
25
|
24.295
|
1
|
8.26672643783333e-07
|
0
|
Igfr_Jak
|
691.882872687412
|
3.51
|
|
13
|
53
|
Akt
|
Jak
|
0.436149598416019
|
667.603179806524
|
25
|
24.279
|
1
|
8.33268296362988e-07
|
0
|
Akt_Jak
|
691.882179806524
|
3.51
|
|
14
|
117
|
Erk
|
Lifr
|
0.328160903048842
|
668.861418427744
|
25
|
23.021
|
1
|
1.60230636592207e-06
|
0.001
|
Erk_Lifr
|
691.882418427744
|
3.33
|
|
15
|
263
|
Mek
|
Jak
|
0.737068544088845
|
668.876713488115
|
25
|
23.006
|
1
|
1.61510480800597e-06
|
0.001
|
Mek_Jak
|
691.882713488115
|
3.33
|
|
16
|
264
|
Mek
|
Lifr
|
0.999174471789514
|
668.992011821064
|
25
|
22.891
|
1
|
1.71494134126871e-06
|
0.001
|
Mek_Lifr
|
691.883011821064
|
3.31
|
|
17
|
116
|
Erk
|
Jak
|
0.209038423031387
|
669.17540261175
|
25
|
22.707
|
1
|
1.8866499932324e-06
|
0.001
|
Erk_Jak
|
691.88240261175
|
3.28
|
|
18
|
305
|
Pi3k
|
Jak
|
0.999729227591684
|
669.279642077345
|
25
|
22.603
|
1
|
1.99183102189693e-06
|
0.001
|
Pi3k_Jak
|
691.882642077345
|
3.27
|
|
19
|
179
|
Gsk3
|
Jak
|
0.99909836782814
|
669.716864297635
|
25
|
22.166
|
1
|
2.5010441078166e-06
|
0.001
|
Gsk3_Jak
|
691.882864297635
|
3.2
|
XO : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
180
|
Gsk3
|
Lifr
|
0.254065052403451
|
417.558306751425
|
25
|
48.431
|
1
|
3.42159633959227e-12
|
0
|
Gsk3_Lifr
|
465.989306751425
|
10.39
|
|
2
|
179
|
Gsk3
|
Jak
|
0.254066047918223
|
417.558306885212
|
25
|
48.431
|
1
|
3.42159633959227e-12
|
0
|
Gsk3_Jak
|
465.989306885212
|
10.39
|
|
3
|
200
|
Igfr
|
Jak
|
0.394692223232032
|
420.726654328766
|
25
|
45.262
|
1
|
1.72324376990218e-11
|
0
|
Igfr_Jak
|
465.988654328766
|
9.71
|
|
4
|
201
|
Igfr
|
Lifr
|
0.394595483955924
|
420.726654602669
|
25
|
45.262
|
1
|
1.72324376990218e-11
|
0
|
Igfr_Lifr
|
465.988654602669
|
9.71
|
|
5
|
29
|
Actr
|
Fgfr
|
-0.0929448139068522
|
421.300154434767
|
25
|
44.689
|
1
|
2.30960806035796e-11
|
0
|
Actr_Fgfr
|
465.989154434767
|
9.59
|
|
6
|
26
|
Actr
|
Bmp4r
|
-0.000140141598918061
|
421.302820080091
|
25
|
44.686
|
1
|
2.3127610937479e-11
|
0
|
Actr_Bmp4r
|
465.988820080091
|
9.59
|
|
7
|
25
|
Actr
|
Bmp4
|
-0.00014013479222055
|
421.302822167555
|
25
|
44.686
|
1
|
2.3127610937479e-11
|
0
|
Actr_Bmp4
|
465.988822167555
|
9.59
|
|
8
|
34
|
Actr
|
Mek
|
-0.766282409199382
|
422.5779805724
|
25
|
43.411
|
1
|
4.43667325100705e-11
|
0
|
Actr_Mek
|
465.9889805724
|
9.32
|
|
9
|
37
|
Actr
|
Raf
|
-0.766282409199382
|
422.5779805724
|
25
|
43.411
|
1
|
4.43667325100705e-11
|
0
|
Actr_Raf
|
465.9889805724
|
9.32
|
|
10
|
38
|
Actr
|
Ras
|
-0.766282409199382
|
422.5779805724
|
25
|
43.411
|
1
|
4.43667325100705e-11
|
0
|
Actr_Ras
|
465.9889805724
|
9.32
|
|
11
|
431
|
mTor
|
Jak
|
0.609483208799542
|
431.486851110413
|
25
|
34.502
|
1
|
4.25765944722656e-09
|
0
|
mTor_Jak
|
465.988851110413
|
7.4
|
|
12
|
53
|
Akt
|
Jak
|
0.740863614758909
|
431.486851123287
|
25
|
34.502
|
1
|
4.25765955824886e-09
|
0
|
Akt_Jak
|
465.988851123287
|
7.4
|
|
13
|
54
|
Akt
|
Lifr
|
0.740742211636115
|
431.486851289899
|
25
|
34.502
|
1
|
4.25765989131577e-09
|
0
|
Akt_Lifr
|
465.988851289899
|
7.4
|
|
14
|
432
|
mTor
|
Lifr
|
0.60943205515569
|
431.48685134728
|
25
|
34.502
|
1
|
4.25766000233807e-09
|
0
|
mTor_Lifr
|
465.98885134728
|
7.4
|
|
15
|
306
|
Pi3k
|
Lifr
|
0.0224485932952633
|
431.486852096483
|
25
|
34.502
|
1
|
4.25766166767261e-09
|
0
|
Pi3k_Lifr
|
465.988852096483
|
7.4
|
|
16
|
305
|
Pi3k
|
Jak
|
0.0223468902094113
|
431.486853872515
|
25
|
34.502
|
1
|
4.25766555345319e-09
|
0
|
Pi3k_Jak
|
465.988853872515
|
7.4
|
|
17
|
188
|
Gsk3
|
Stat3
|
0.159954112803069
|
432.097840299189
|
25
|
33.891
|
1
|
5.82808634685961e-09
|
0
|
Gsk3_Stat3
|
465.988840299189
|
7.27
|
|
18
|
194
|
Igfr
|
Bmp4r
|
4.13152048247566
|
433.320215561465
|
25
|
32.669
|
1
|
1.09274319592956e-08
|
0
|
Igfr_Bmp4r
|
465.989215561465
|
7.01
|
|
19
|
193
|
Igfr
|
Bmp4
|
1
|
433.320218010893
|
25
|
32.669
|
1
|
1.09274457260611e-08
|
0
|
Igfr_Bmp4
|
465.989218010893
|
7.01
|
|
20
|
173
|
Gsk3
|
Bmp4r
|
7.27536487596788
|
436.465612865036
|
25
|
29.523
|
1
|
5.52440697632051e-08
|
0
|
Gsk3_Bmp4r
|
465.988612865036
|
6.34
|
Intersection List
|
|
Link
|
Res_delta_XX
|
adj_pval_XX
|
Perc_Res_delta_XX
|
Res_delta_XO
|
adj_pval_XO
|
Perc_Res_delta_XO
|
Total_DelResidual
|
Tot_Percentage_DelResidual
|
|
1
|
Actr_Bmp4r
|
40.45
|
0
|
5.85
|
44.686
|
0
|
9.59
|
85.136
|
15.44
|
|
5
|
Actr_Fgfr
|
40.021
|
0
|
5.78
|
44.689
|
0
|
9.59
|
84.71
|
15.37
|
|
2
|
Actr_Mek
|
40.187
|
0
|
5.81
|
43.411
|
0
|
9.32
|
83.598
|
15.13
|
|
3
|
Actr_Raf
|
40.187
|
0
|
5.81
|
43.411
|
0
|
9.32
|
83.598
|
15.13
|
|
4
|
Actr_Ras
|
40.187
|
0
|
5.81
|
43.411
|
0
|
9.32
|
83.598
|
15.13
|
|
8
|
Actr_Bmp4
|
28.094
|
0
|
4.06
|
44.686
|
0
|
9.59
|
72.78
|
13.65
|
|
14
|
Gsk3_Jak
|
22.166
|
0.001
|
3.2
|
48.431
|
0
|
10.39
|
70.597
|
13.59
|
|
9
|
Igfr_Lifr
|
24.372
|
0
|
3.52
|
45.262
|
0
|
9.71
|
69.634
|
13.23
|
|
11
|
Igfr_Jak
|
24.295
|
0
|
3.51
|
45.262
|
0
|
9.71
|
69.557
|
13.22
|
|
6
|
Igfr_Bmp4r
|
31.5
|
0
|
4.55
|
32.669
|
0
|
7.01
|
64.169
|
11.56
|
|
10
|
Akt_Lifr
|
24.314
|
0
|
3.51
|
34.502
|
0
|
7.4
|
58.816
|
10.91
|
|
12
|
Akt_Jak
|
24.279
|
0
|
3.51
|
34.502
|
0
|
7.4
|
58.781
|
10.91
|
|
13
|
Pi3k_Jak
|
22.603
|
0.001
|
3.27
|
34.502
|
0
|
7.4
|
57.105
|
10.67
|
|
7
|
Gsk3_Bmp4r
|
28.975
|
0
|
4.19
|
29.523
|
0
|
6.34
|
58.498
|
10.53
|
LA7
XX : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
215
|
Jak
|
Bmp4r
|
0.420445924238593
|
627.885090183765
|
26
|
23.25
|
1
|
1.42232177680057e-06
|
0
|
Jak_Bmp4r
|
651.135090183765
|
3.57
|
XO : List post filter
|
|
adj_idx
|
from
|
to
|
value
|
residual
|
df
|
Res_delta
|
df_delta
|
pval
|
adj_pval
|
Link
|
Base_Res
|
Perc_Res_delta
|
|
1
|
180
|
Gsk3
|
Lifr
|
0.198638973271869
|
385.047283318677
|
26
|
36.255
|
1
|
1.73138925418925e-09
|
0
|
Gsk3_Lifr
|
421.302283318677
|
8.61
|
|
2
|
179
|
Gsk3
|
Jak
|
0.198636048215218
|
385.047294407416
|
26
|
36.255
|
1
|
1.73139913517417e-09
|
0
|
Gsk3_Jak
|
421.302294407416
|
8.61
|
|
3
|
188
|
Gsk3
|
Stat3
|
0.155300697027229
|
387.3530474701
|
26
|
33.949
|
1
|
5.65766333782136e-09
|
0
|
Gsk3_Stat3
|
421.3020474701
|
8.06
|
|
4
|
201
|
Igfr
|
Lifr
|
0.348512997176483
|
388.891352120685
|
26
|
32.411
|
1
|
1.24799656164853e-08
|
0
|
Igfr_Lifr
|
421.302352120685
|
7.69
|
|
5
|
200
|
Igfr
|
Jak
|
0.3485124279963
|
388.891354814541
|
26
|
32.411
|
1
|
1.24799828249422e-08
|
0
|
Igfr_Jak
|
421.302354814541
|
7.69
|
|
6
|
209
|
Igfr
|
Stat3
|
0.248199280468535
|
392.773026133605
|
26
|
28.529
|
1
|
9.23059626511957e-08
|
0
|
Igfr_Stat3
|
421.302026133605
|
6.77
|
|
7
|
234
|
Lifr
|
Akt
|
0.0465599314232042
|
395.083809486956
|
26
|
26.218
|
1
|
3.04933785444383e-07
|
0
|
Lifr_Akt
|
421.301809486956
|
6.22
|
|
8
|
241
|
Lifr
|
Igfr
|
0.134000793526346
|
395.630083197019
|
26
|
25.672
|
1
|
4.04669677656067e-07
|
0
|
Lifr_Igfr
|
421.302083197019
|
6.09
|
|
9
|
246
|
Lifr
|
Pi3k
|
137.800332148298
|
395.7374828565
|
26
|
25.565
|
1
|
4.27831139848678e-07
|
0
|
Lifr_Pi3k
|
421.3024828565
|
6.07
|
|
10
|
240
|
Lifr
|
Gsk3
|
0.122823623661381
|
395.921691108318
|
26
|
25.38
|
1
|
4.70694108578584e-07
|
0
|
Lifr_Gsk3
|
421.301691108318
|
6.02
|
|
11
|
54
|
Akt
|
Lifr
|
0.56618882474856
|
397.020494865756
|
26
|
24.282
|
1
|
8.32336903400233e-07
|
0
|
Akt_Lifr
|
421.302494865756
|
5.76
|
|
12
|
431
|
mTor
|
Jak
|
0.465337458856917
|
397.020496692259
|
26
|
24.282
|
1
|
8.32337692657781e-07
|
0
|
mTor_Jak
|
421.302496692259
|
5.76
|
|
13
|
432
|
mTor
|
Lifr
|
0.465338156421058
|
397.020501062787
|
26
|
24.282
|
1
|
8.32339581258168e-07
|
0
|
mTor_Lifr
|
421.302501062787
|
5.76
|
|
14
|
53
|
Akt
|
Jak
|
0.566149713542637
|
397.020501600915
|
26
|
24.282
|
1
|
8.32339813849892e-07
|
0
|
Akt_Jak
|
421.302501600915
|
5.76
|
|
15
|
305
|
Pi3k
|
Jak
|
0.00173202223928323
|
397.020638990924
|
26
|
24.281
|
1
|
8.32399185357602e-07
|
0
|
Pi3k_Jak
|
421.301638990924
|
5.76
|
|
16
|
306
|
Pi3k
|
Lifr
|
0.000622528208386818
|
397.020652026436
|
26
|
24.281
|
1
|
8.32404818740251e-07
|
0
|
Pi3k_Lifr
|
421.301652026436
|
5.76
|
Intersection List
## Warning in htmlTable.data.frame(my_ext_list, align.header = "c", align = "c", :
## my_ext_list is an empty object
|
Link
|
Res_delta_XX
|
adj_pval_XX
|
Perc_Res_delta_XX
|
Res_delta_XO
|
adj_pval_XO
|
Perc_Res_delta_XO
|
Total_DelResidual
|
Tot_Percentage_DelResidual
|
Summary
Links Added and Residuals
|
|
Model_iteration
|
Links
|
res_p_001_XX
|
res_p_001_XO
|
|
1
|
Init
|
Init Network
|
2056.3
|
1603.72
|
|
2
|
1
|
Jak->Fgfr
|
1515
|
1063.56
|
|
3
|
2
|
Gsk3->Igfr
|
970.8
|
970.63
|
|
4
|
3
|
Bmp4r->Fgfr
|
838.79
|
867.08
|
|
5
|
4
|
Erk->Raf
|
798.31
|
611.48
|
|
6
|
5
|
Jak->Gsk3
|
737.95
|
547.33
|
|
7
|
6
|
Bmp4r->Smad2
|
691.88
|
465.99
|
|
8
|
7
|
Actr->Bmp4r
|
651.14
|
421.3
|
