Best %residual, pvalue < 0.001

Extending the models for XX and XO data, so as to keep a consensus network as far as possible.

Steps to find the common link to be added :
1.) Read in the extension.csv for both cell lines
2.) Remove links from TFs and Ligands
3.) Retain only links that have adjusted p-value < 0.001 and value !=0
4.) Calculate %improvement in residual for each cell line
5.) Find the intersection list,(Links that appear in both lists)
6.) Calculate the sum of %improvement in residual
7.) Order the intersection list by descending order of sum of %improvement in residual.
8.) Add the link with Max sum of %improvement to both models.

XX

Initial-Fit

Model residual = 2056

Link Extension :

	adj_idx	from	to	value	residual	df	Res_delta	df_delta	pval	adj_pval
1	178	Gsk3	Igfr	1.41702633999479	1277.72293709044	18	778.578532266446	2	0	0
2	171	Gsk3	Akt	1.99559218209568	1288.71968912995	18	767.581780226938	2	0	0
3	183	Gsk3	Pi3k	15.0727241980515	1289.13219166705	18	767.169277689836	2	0	0
4	176	Gsk3	Fgfr	0.191531955466209	1372.05906755829	18	684.242401798598	2	0	0
5	409	Stat3	Igfr	0.999122672339906	1502.20198472129	17	554.099484635595	1	0	0
6	220	Jak	Igfr	0.0556087755678092	1503.11324628534	17	553.18822307155	1	0	0
7	407	Stat3	Fgfr	0.300460094833736	1515.3185437816	17	540.982925575287	1	0	0
8	218	Jak	Fgfr	0.0167866219398153	1515.31854382928	17	540.982925527604	1	0	0
9	414	Stat3	Pi3k	6.92522239192528	1519.02257760899	17	537.278891747894	1	0	0
10	225	Jak	Pi3k	0.386430781716265	1519.02257765008	17	537.27889170681	1	0	0
11	402	Stat3	Akt	0.536041523286274	1523.34265160666	17	532.958817750223	1	0	0
12	213	Jak	Akt	0.0299202958574827	1523.34265280937	17	532.958816547514	1	0	0
13	92	Bmp4r	Fgfr	100.000006308235	1854.77449547632	18	201.526973880564	2	0	0
14	29	Actr	Fgfr	-0.792450311159814	1894.64741080012	17	161.654058556764	1	0	0
15	386	Smad2	Fgfr	-2.41665063274279	1894.64741080539	17	161.654058551497	1	0	0
16	8	Activin	Fgfr	-0.792497812660148	1894.64741081346	17	161.654058543427	1	0	0
17	384	Smad2	Erk	-2.2971200884708	1908.4536014253	17	147.847867931582	1	0	0
18	6	Activin	Erk	-0.753278182588148	1908.45360143937	17	147.847867917512	1	0	0
19	27	Actr	Erk	-0.753277209074847	1908.45360160677	17	147.847867750115	1	0	0
20	13	Activin	Mek	-0.179931424708554	1930.52896307738	17	125.77250627951	1	0	0

LA1:Jak -> Fgfr

Model residual = 1515

Link Extension :

	adj_idx	from	to	value	residual	df	Res_delta	df_delta	pval	adj_pval
1	178	Gsk3	Igfr	1.07092508964865	971.812846969374	19	543.189125194063	2	0	0
2	171	Gsk3	Akt	1.68236052914573	980.75472533061	19	534.247246832827	2	0	0
3	183	Gsk3	Pi3k	0.947902586974397	981.104897412239	19	533.897074751199	2	0	0
4	176	Gsk3	Fgfr	0.0366456344380372	1042.9909365935	19	472.011035569937	2	0	0
5	179	Gsk3	Jak	3.57901785216984	1186.00515881884	19	328.996813344597	2	0	0
6	180	Gsk3	Lifr	3.57012904221758	1186.0051592358	19	328.996812927639	2	0	0
7	92	Bmp4r	Fgfr	100.000000018277	1379.2932137683	19	135.708758395137	2	0	0
8	96	Bmp4r	Lifr	13.860198582644	1405.40002957656	19	109.601942586875	2	0	0
9	95	Bmp4r	Jak	10.0003455473115	1405.40002968353	19	109.601942479911	2	0	0
10	90	Bmp4r	Erk	0.0999812891114909	1409.88137320982	19	105.120598953621	2	0	0
11	6	Activin	Erk	-0.615064354135591	1431.0541333998	18	83.9478387636343	1	0	0
12	27	Actr	Erk	-0.615066582280294	1431.05413356246	18	83.9478386009775	1	0	0
13	384	Smad2	Erk	-1.8756670748869	1431.05413414638	18	83.9478380170569	1	0	0
14	97	Bmp4r	Mek	0.0950267626764539	1432.52845502105	19	82.4735171423897	2	0	0
15	100	Bmp4r	Raf	0.0950267626764539	1432.52845502105	19	82.4735171423897	2	0	0
16	101	Bmp4r	Ras	0.0950267626764539	1432.52845502105	19	82.4735171423897	2	0	0
17	409	Stat3	Igfr	41.2673434838526	1435.74300563464	18	79.258966528794	1	0	0
18	220	Jak	Igfr	0.368915097530597	1435.74303261254	18	79.2589395508951	1	0	0
19	29	Actr	Fgfr	-0.183054053565317	1436.60116940405	18	78.4008027593868	1	0	0
20	386	Smad2	Fgfr	-0.558216361851173	1436.60116951395	18	78.400802649488	1	0	0

LA2:Gsk3->Igfr

Model residual = 971

Link Extension :

	adj_idx	from	to	value	residual	df	Res_delta	df_delta	pval	adj_pval
1	92	Bmp4r	Fgfr	100.000000000003	841.461666755043	21	129.336847807388	2	0	0
2	90	Bmp4r	Erk	10.0000192017944	866.760153279043	21	104.038361283389	2	0	0
3	95	Bmp4r	Jak	10.0001269820917	879.28557415186	21	91.5129404105718	2	0	0
4	96	Bmp4r	Lifr	214.317017758443	883.773260598781	21	87.0252539636506	2	0	0
5	6	Activin	Erk	-0.61201399267674	887.232621555181	20	83.5658930072506	1	0	0
6	97	Bmp4r	Mek	1.0052953446443	889.238103252294	21	81.5604113101375	2	0	0
7	100	Bmp4r	Raf	1.0052953446443	889.238103252294	21	81.5604113101375	2	0	0
8	101	Bmp4r	Ras	1.0052953446443	889.238103252294	21	81.5604113101375	2	0	0
9	27	Actr	Erk	-0.327920234741696	899.875257200335	20	70.9232573620963	1	0	0
10	384	Smad2	Erk	-1	899.875257200335	20	70.9232573620963	1	0	0
11	402	Stat3	Akt	0.000328137939887829	901.431902293253	20	69.3666122691785	1	1.11022302462516e-16	3.7858605139718e-14
12	220	Jak	Igfr	5.55539436656802e-05	901.522264003501	20	69.2762505589305	1	1.11022302462516e-16	3.7858605139718e-14
13	409	Stat3	Igfr	0.000146754744396415	902.221664448101	20	68.5768501143306	1	1.11022302462516e-16	3.7858605139718e-14
14	408	Stat3	Gsk3	0.000160748619874925	902.324997882948	20	68.4735166794833	1	1.11022302462516e-16	3.7858605139718e-14
15	414	Stat3	Pi3k	1.17008465928704e-05	903.082143837999	20	67.7163707244331	1	2.22044604925031e-16	7.57172102794356e-14
16	219	Jak	Gsk3	2.62365545377848e-05	903.256424772377	20	67.5420897900549	1	2.22044604925031e-16	7.57172102794356e-14
17	213	Jak	Akt	7.21679806108667e-05	903.376234376356	20	67.4222801860755	1	2.22044604925031e-16	7.57172102794356e-14
18	225	Jak	Pi3k	3.34763735789056e-06	903.440683415853	20	67.3578311465785	1	2.22044604925031e-16	7.57172102794356e-14
19	34	Actr	Mek	-0.143655120450202	903.646874708811	20	67.1516398536204	1	2.22044604925031e-16	7.57172102794356e-14
20	37	Actr	Raf	-0.143655120450202	903.646874708811	20	67.1516398536204	1	2.22044604925031e-16	7.57172102794356e-14

LA3:Bmp4r->Fgfr

Model residual = 839

Link Extension :

	adj_idx	from	to	value	residual	df	Res_delta	df_delta	pval	adj_pval
1	213	Jak	Akt	0.000559101694508571	776.613258315932	22	62.1769979062434	1	3.10862446895044e-15	1.05693231944315e-12
2	402	Stat3	Akt	0.00163958611575612	776.618590686197	22	62.1716655359784	1	3.10862446895044e-15	1.05693231944315e-12
3	408	Stat3	Gsk3	0.000164346770395023	778.024536203888	22	60.7657200182869	1	6.43929354282591e-15	2.18935980456081e-12
4	414	Stat3	Pi3k	0.000558220477783345	778.106835378228	22	60.683420843947	1	6.66133814775094e-15	2.26485497023532e-12
5	409	Stat3	Igfr	0.00031984920277261	778.130802407887	22	60.6594538142881	1	6.77236045021345e-15	2.30260255307257e-12
6	225	Jak	Pi3k	8.97904410870197e-05	778.167767008921	22	60.6224892132536	1	6.88338275267597e-15	2.34035013590983e-12
7	226	Jak	Raf	-3.17320997476433	796.125380312149	22	42.6648759100262	1	6.49684750442248e-11	2.20892815150364e-08
8	223	Jak	Mek	-3.21824554283048	796.307860112286	22	42.4823961098889	1	7.13212822134324e-11	2.4249235952567e-08
9	227	Jak	Ras	-3.24588645068019	796.497908448933	22	42.292347773242	1	7.8599460273665e-11	2.67238164930461e-08
10	103	Bmp4r	Smad2	100.02186644193	797.416938400438	22	41.3733178217368	1	1.25762289471254e-10	4.27591784202264e-08
11	86	Bmp4r	Actr	100.010657724698	797.452728577297	22	41.3375276448785	1	1.28086097284097e-10	4.3549273076593e-08
12	27	Actr	Erk	-0.327920237439189	798.210046345649	22	40.5802098765256	1	1.88708271231519e-10	6.41608122187165e-08
13	384	Smad2	Erk	-1	798.210046345649	22	40.5802098765256	1	1.88708271231519e-10	6.41608122187165e-08
14	118	Erk	Mek	-0.0986955651077006	801.650786718166	22	37.1394695040086	1	1.09975040185617e-09	3.73915136631098e-07
15	122	Erk	Ras	-0.0986955651090815	801.650787921435	22	37.1394683007397	1	1.09975106798998e-09	3.73915363116593e-07
16	121	Erk	Raf	-0.0986955651101688	801.650787967443	22	37.139468254732	1	1.09975106798998e-09	3.73915363116593e-07
17	412	Stat3	Mek	-0.25107346302282	802.05483033835	22	36.7354258838252	1	1.35298316994437e-09	4.60014277781086e-07
18	416	Stat3	Ras	-0.251073465040761	802.054830353862	22	36.7354258683125	1	1.35298316994437e-09	4.60014277781086e-07
19	415	Stat3	Raf	-0.251073466548989	802.054830438638	22	36.7354257835368	1	1.35298316994437e-09	4.60014277781086e-07
20	220	Jak	Igfr	8.04755410748596e-06	803.218989797017	22	35.5712664251585	1	2.45887887828644e-09	8.3601881861739e-07

LA4:Erk->Raf

Model residual = 798

Link Extension :

	adj_idx	from	to	value	residual	df	Res_delta	df_delta	pval	adj_pval
1	213	Jak	Akt	0.000707406177266371	737.960495916585	23	60.3505499670268	1	7.99360577730113e-15	2.70983235850508e-12
2	402	Stat3	Akt	0.00403762213564797	739.274618886038	23	59.0364269975745	1	1.54321000422897e-14	5.23148191433621e-12
3	220	Jak	Igfr	5.03600959182369e-05	739.346387831751	23	58.964658051861	1	1.60982338570648e-14	5.45730127754497e-12
4	219	Jak	Gsk3	8.91364101617684e-05	739.36887470925	23	58.9421711743623	1	1.62092561595273e-14	5.49493783807976e-12
5	414	Stat3	Pi3k	0.000701899934766581	739.373798236313	23	58.9372476472989	1	1.63202784619898e-14	5.53257439861454e-12
6	408	Stat3	Gsk3	0.000169610934882156	739.387623592905	23	58.9234222907071	1	1.64313007644523e-14	5.57021095914933e-12
7	409	Stat3	Igfr	8.16173463425947e-05	739.442288331576	23	58.8687575520361	1	1.68753899743024e-14	5.72075720128851e-12
8	225	Jak	Pi3k	0.000323749018200995	739.465644562853	23	58.8454013207592	1	1.70974345792274e-14	5.79603032235809e-12
9	6	Activin	Erk	-0.999743480639336	760.328450472915	23	37.9825954106967	1	7.13785364148123e-10	2.41973238446214e-07
10	86	Bmp4r	Actr	0.1	760.705112213975	23	37.6059336696374	1	8.65806981664718e-10	2.93508566784339e-07
11	103	Bmp4r	Smad2	0.1	760.705112213975	23	37.6059336696374	1	8.65806981664718e-10	2.93508566784339e-07
12	27	Actr	Erk	-0.327920237444485	761.52862579633	23	36.7824200872823	1	1.32075872461002e-09	4.47737207642797e-07
13	384	Smad2	Erk	-1	761.52862579633	23	36.7824200872823	1	1.32075872461002e-09	4.47737207642797e-07
14	34	Actr	Mek	-0.147675991438342	763.080355755634	23	35.2306901279777	1	2.92871626950131e-09	9.92834815360944e-07
15	37	Actr	Raf	-0.147675991438342	763.080355755634	23	35.2306901279777	1	2.92871626950131e-09	9.92834815360944e-07
16	38	Actr	Ras	-0.147675991438342	763.080355755634	23	35.2306901279777	1	2.92871626950131e-09	9.92834815360944e-07
17	415	Stat3	Raf	-0.347655472010461	764.509160427224	23	33.8018854563885	1	6.10196959627274e-09	2.06856769313646e-06
18	416	Stat3	Ras	-0.347655486454759	764.509383657584	23	33.801662226028	1	6.10266981393437e-09	2.06880506692375e-06
19	412	Stat3	Mek	-0.347655508994201	764.509721078212	23	33.8013248053998	1	6.10372841158835e-09	2.06916393152845e-06
20	313	Pi3k	Smad2	0.0731215380340072	765.019323945664	23	33.2917219379483	1	7.93195686910053e-09	2.68893337862508e-06

LA5:Jak->Gsk3

Model residual = 738

Link Extension :

	adj_idx	from	to	value	residual	df	Res_delta	df_delta	pval	adj_pval
1	6	Activin	Erk	-0.999100219336439	681.894033658867	24	56.0607272911691	1	7.02771174587724e-14	2.37536657010651e-11
2	34	Actr	Mek	-0.169510536243249	691.497669974297	24	46.457090975739	1	9.3647312127132e-12	3.16527914989706e-09
3	37	Actr	Raf	-0.169510524829761	691.497670173476	24	46.4570907765599	1	9.3647312127132e-12	3.16527914989706e-09
4	38	Actr	Ras	-0.169510524829761	691.497670173476	24	46.4570907765599	1	9.3647312127132e-12	3.16527914989706e-09
5	384	Smad2	Erk	-1.00042541472319	692.068671499042	24	45.8860894509942	1	1.25333077249934e-11	4.23625801104777e-09
6	27	Actr	Erk	-0.329216993650508	692.07872455242	24	45.8760363976163	1	1.25978116827241e-11	4.25806034876075e-09
7	86	Bmp4r	Actr	0.1	692.718298841271	24	45.2364621087655	1	1.74623648874217e-11	5.90227933194853e-09
8	103	Bmp4r	Smad2	0.1	692.718298841271	24	45.2364621087655	1	1.74623648874217e-11	5.90227933194853e-09
9	13	Activin	Mek	-0.102939000333209	697.615694892658	24	40.3390660573785	1	2.1349688683614e-10	7.21619477506153e-08
10	16	Activin	Raf	-0.102939000333209	697.615694892658	24	40.3390660573785	1	2.1349688683614e-10	7.21619477506153e-08
11	17	Activin	Ras	-0.102939000340934	697.61569497916	24	40.3390659708757	1	2.1349688683614e-10	7.21619477506153e-08
12	8	Activin	Fgfr	-0.268891542369133	697.969720461774	24	39.9850404882623	1	2.55915288960296e-10	8.64993676685801e-08
13	29	Actr	Fgfr	-0.931701344045143	698.398913256414	24	39.5558476936221	1	3.1881031148373e-10	1.07757885281501e-07
14	208	Igfr	Smad2	0.252182901106177	703.801214372991	24	34.1535465770447	1	5.09303343942946e-09	1.72144530252716e-06
15	191	Igfr	Actr	0.25201962503734	703.801382643909	24	34.153378306127	1	5.09347386490333e-09	1.72159416633733e-06
16	313	Pi3k	Smad2	0.30512095678214	703.822303571833	24	34.1324573782036	1	5.14852960264989e-09	1.74020300569566e-06
17	296	Pi3k	Actr	0.30512095702263	703.822303599494	24	34.1324573505418	1	5.14852960264989e-09	1.74020300569566e-06
18	187	Gsk3	Smad2	0.253667914857315	703.846862678593	24	34.1078982714434	1	5.21392051755498e-09	1.76230513493358e-06
19	170	Gsk3	Actr	0.253710860378536	703.847228684446	24	34.1075322655903	1	5.21490128857494e-09	1.76263663553833e-06
20	439	mTor	Smad2	0.513028961424221	703.894000572903	24	34.0607603771336	1	5.34176891608951e-09	1.80551789363825e-06

LA6:Bmp4r->Smad2

Model residual = 692

Link Extension :

	adj_idx	from	to	value	residual	df	Res_delta	df_delta	pval	adj_pval
1	6	Activin	Erk	-0.997740015496855	635.738196860532	25	56.1443512091877	1	6.7390537594747e-14	2.27106111694297e-11
2	27	Actr	Erk	-0.3764990238487	642.112873213278	25	49.7696748564417	1	1.72895031624876e-12	5.82656256575832e-10
3	13	Activin	Mek	-0.161779764555631	645.914166189683	25	45.9683818800364	1	1.20177201523575e-11	4.04997169134448e-09
4	16	Activin	Raf	-0.161779764555631	645.914166189683	25	45.9683818800364	1	1.20177201523575e-11	4.04997169134448e-09
5	17	Activin	Ras	-0.161779764555631	645.914166189683	25	45.9683818800364	1	1.20177201523575e-11	4.04997169134448e-09
6	384	Smad2	Erk	-1.19408610007656	646.087356464795	25	45.7951916049243	1	1.31284982884949e-11	4.42430392322278e-09
7	26	Actr	Bmp4r	-0.114345956401805	651.432322957465	25	40.4502251122551	1	2.01689220880041e-10	6.79692674365738e-08
8	5	Activin	Bmp4r	-0.135186295550368	651.446998454898	25	40.4355496148218	1	2.03209782334568e-10	6.84816966467494e-08
9	34	Actr	Mek	-0.184466635341531	651.695610071583	25	40.1869379981371	1	2.30786167954022e-10	7.77749386005054e-08
10	37	Actr	Raf	-0.184466635341531	651.695610071583	25	40.1869379981371	1	2.30786167954022e-10	7.77749386005054e-08
11	38	Actr	Ras	-0.184466635341531	651.695610071583	25	40.1869379981371	1	2.30786167954022e-10	7.77749386005054e-08
12	29	Actr	Fgfr	-0.19305395874701	651.86148251821	25	40.0210655515094	1	2.51238807535969e-10	8.46674781396215e-08
13	8	Activin	Fgfr	-0.272144558486586	652.05207145613	25	39.8304766135902	1	2.7698909832452e-10	9.33453261353632e-08
14	194	Igfr	Bmp4r	9.52513344378078	660.382834653848	25	31.4997134158713	1	1.99469695205678e-08	6.72212872843135e-06
15	173	Gsk3	Bmp4r	8.35970405891355	662.907058780043	25	28.9754892896766	1	7.32999207997409e-08	2.47020733095127e-05
16	25	Actr	Bmp4	-0.0464156641394266	663.78872868241	25	28.0938193873098	1	1.15574366854609e-07	3.89485616300032e-05
17	4	Activin	Bmp4	-0.0464156642277728	663.788728725367	25	28.0938193443523	1	1.15574369408122e-07	3.89485624905371e-05
18	395	Smad2	Ras	-0.119503971763457	664.950226437352	25	26.9323216323673	1	2.10705583314486e-07	7.10077815769818e-05
19	394	Smad2	Raf	-0.119503971643125	664.950227312366	25	26.9323207573539	1	2.10705678682643e-07	7.10078137160507e-05
20	391	Smad2	Mek	-0.119503971990989	664.950227955385	25	26.9323201143351	1	2.10705748737716e-07	7.10078373246103e-05

LA7:Actr->Bmp4r

Model residual = 651

Link Extension :

	adj_idx	from	to	value	residual	df	Res_delta	df_delta	pval	adj_pval
1	136	Fgf4	Igfr	-0.000171702506999909	627.407489706755	26	23.7278475050618	1	1.10965255895046e-06	0.000372843259807355
2	141	Fgf4	Pi3k	-9.56625374187201e-05	627.439128294579	26	23.6962089172383	1	1.12804529073252e-06	0.000379023217686127
3	129	Fgf4	Akt	-0.000101035992815949	627.441534220169	26	23.6938029916479	1	1.12945639374473e-06	0.000379497348298229
4	135	Fgf4	Gsk3	-4.13969970059556e-05	627.514826205649	26	23.6205110061685	1	1.17330193050158e-06	0.000394229448648531
5	215	Jak	Bmp4r	0.420445924238593	627.885090183765	26	23.2502470280523	1	1.42232177680057e-06	0.000477900117004991
6	404	Stat3	Bmp4r	0.695556761330991	628.499523263902	26	22.6358139479154	1	1.95800549551706e-06	0.000657889846493732
7	117	Erk	Lifr	0.157020092622241	629.930962278401	26	21.2043749334161	1	4.12821115380879e-06	0.00138707894767975
8	264	Mek	Lifr	0.508853918161392	630.02043490386	26	21.1149023079566	1	4.32551195939102e-06	0.00145337201835538
9	263	Mek	Jak	0.416284621142674	630.132594660481	26	21.0027425513357	1	4.58626392585426e-06	0.00154098467908703
10	116	Erk	Jak	0.117714567303387	630.144286561923	26	20.9910506498939	1	4.61433765941432e-06	0.00155041745356321
11	54	Akt	Lifr	0.293890041522473	630.779454383863	26	20.3558828279544	1	6.42951189366858e-06	0.00216031599627264
12	53	Akt	Jak	0.224724364896233	630.811466634632	26	20.3238705771853	1	6.53798176786236e-06	0.00219676187400175
13	282	NoLif	Gsk3	0.000818038618045161	630.834893059483	26	20.300444152334	1	6.61852181327305e-06	0.00222382332925974
14	240	Lifr	Gsk3	0.00135681037595657	630.852810263147	26	20.2825269486699	1	6.68079267540644e-06	0.00224474633893656
15	305	Pi3k	Jak	0.573003172148801	630.867938359368	26	20.2673988524492	1	6.7338277520701e-06	0.00226256612469555
16	200	Igfr	Jak	0.75580402001186	631.967408142999	26	19.1679290688176	1	1.197077927928e-05	0.00402218183783808
17	431	mTor	Jak	0.996688816163702	632.060010869192	26	19.0753263426247	1	1.25659011062096e-05	0.00422214277168643
18	179	Gsk3	Jak	0.3598489800363	632.381355504872	26	18.753981706945	1	1.4871253526505e-05	0.00499674118490568
19	314	Pi3k	Stat3	0.241688832998278	632.45767749664	26	18.6776597151769	1	1.54785431869531e-05	0.00520079051081624
20	62	Akt	Stat3	0.0907717294756864	632.587036018461	26	18.5483011933563	1	1.65652797667892e-05	0.00556593400164117

XO

Initial-Fit

Model residual = 1604

Link Extension :

	adj_idx	from	to	value	residual	df	Res_delta	df_delta	pval	adj_pval
1	218	Jak	Fgfr	20.4555622071971	1087.3433154512	17	516.380135475511	1	0	0
2	407	Stat3	Fgfr	21.5653831972927	1087.34331580481	17	516.380135121903	1	0	0
3	405	Stat3	Erk	0.814942015154757	1259.70107126209	17	344.022379664625	1	0	0
4	216	Jak	Erk	0.694604520012992	1259.70107127078	17	344.022379655935	1	0	0
5	223	Jak	Mek	0.15351221946598	1274.91766666864	17	328.805784258074	1	0	0
6	226	Jak	Raf	0.15351221946598	1274.91766666864	17	328.805784258074	1	0	0
7	227	Jak	Ras	0.15351221946598	1274.91766666864	17	328.805784258074	1	0	0
8	412	Stat3	Mek	0.169230604339685	1274.91766667305	17	328.805784253661	1	0	0
9	415	Stat3	Raf	0.169230604339685	1274.91766667305	17	328.805784253661	1	0	0
10	416	Stat3	Ras	0.169230604339685	1274.91766667305	17	328.805784253661	1	0	0
11	281	NoLif	Fgfr	-26.1357634523209	1284.20827339087	17	319.515177535837	1	0	0
12	239	Lifr	Fgfr	-22.8862756816318	1284.20827339159	17	319.515177535118	1	0	0
13	237	Lifr	Erk	-1.09664060760853	1307.81404086072	17	295.90941006599	1	0	0
14	279	NoLif	Erk	-1.09664013272317	1307.81404087539	17	295.909410051324	1	0	0
15	286	NoLif	Mek	-0.239871655402394	1311.08678087335	17	292.63667005336	1	0	0
16	289	NoLif	Raf	-0.239871655402394	1311.08678087335	17	292.63667005336	1	0	0
17	290	NoLif	Ras	-0.239871655402394	1311.08678087335	17	292.63667005336	1	0	0
18	244	Lifr	Mek	-0.239871706973556	1311.08678087424	17	292.636670052469	1	0	0
19	247	Lifr	Raf	-0.239871706973556	1311.08678087424	17	292.636670052469	1	0	0
20	248	Lifr	Ras	-0.239871706973556	1311.08678087424	17	292.636670052469	1	0	0

LA1:Jak -> Fgfr

Model residual = 1064

Link Extension :

	adj_idx	from	to	value	residual	df	Res_delta	df_delta	pval	adj_pval
1	118	Erk	Mek	-1.3134031405681	815.631614385471	18	247.924428475258	1	0	0
2	121	Erk	Raf	-1.3134031405681	815.631614385471	18	247.924428475258	1	0	0
3	122	Erk	Ras	-1.3134031405681	815.631614385471	18	247.924428475258	1	0	0
4	269	Mek	Ras	-5.83516557728466	815.631614406535	18	247.924428454195	1	0	0
5	268	Mek	Raf	-5.83501103034113	815.631614489309	18	247.92442837142	1	0	0
6	92	Bmp4r	Fgfr	9.99999909080412	953.75112000258	19	109.80492285815	2	0	0
7	386	Smad2	Fgfr	-0.138087505692968	960.885942418047	18	102.670100442683	1	0	0
8	8	Activin	Fgfr	-0.107642148736655	960.885942661641	18	102.670100199089	1	0	0
9	29	Actr	Fgfr	-0.107633817589381	960.885942690023	18	102.670100170707	1	0	0
10	97	Bmp4r	Mek	99.9999999996109	962.159252464793	19	101.396790395936	2	0	0
11	100	Bmp4r	Raf	99.9999999996109	962.159252464793	19	101.396790395936	2	0	0
12	101	Bmp4r	Ras	99.9999999996109	962.159252464793	19	101.396790395936	2	0	0
13	179	Gsk3	Jak	0.109872274801102	962.880760353095	19	100.675282507635	2	0	0
14	180	Gsk3	Lifr	0.109861109481093	962.880760387493	19	100.675282473237	2	0	0
15	90	Bmp4r	Erk	1.00643342523252	964.022333976477	19	99.5337088842523	2	0	0
16	27	Actr	Erk	-0.763289910081632	964.487926033674	18	99.0681168270553	1	0	0
17	384	Smad2	Erk	-0.979127107684436	964.487926061329	18	99.0681167994004	1	0	0
18	6	Activin	Erk	-0.763290536507029	964.487926141927	18	99.0681167188022	1	0	0
19	391	Smad2	Mek	-0.192631121143629	966.972716683902	18	96.583326176828	1	0	0
20	394	Smad2	Raf	-0.192631121143629	966.972716683902	18	96.583326176828	1	0	0

LA2:Gsk3->Igfr

Model residual = 971

Link Extension :

	adj_idx	from	to	value	residual	df	Res_delta	df_delta	pval	adj_pval
1	92	Bmp4r	Fgfr	100.000000000769	869.218810406832	21	101.412816378881	2	0	0
2	97	Bmp4r	Mek	100.000000005133	871.46389835036	21	99.1677284353533	2	0	0
3	100	Bmp4r	Raf	100.000000005133	871.46389835036	21	99.1677284353533	2	0	0
4	101	Bmp4r	Ras	100.000000005133	871.46389835036	21	99.1677284353533	2	0	0
5	90	Bmp4r	Erk	100.000000093328	871.627560561552	21	99.0040662241618	2	0	0
6	27	Actr	Erk	-0.754763746009187	872.382026119069	20	98.2496006666448	1	0	0
7	384	Smad2	Erk	-1	872.722753102278	20	97.9088736834352	1	0	0
8	13	Activin	Mek	-0.151274324677221	875.395343987362	20	95.2362827983517	1	0	0
9	16	Activin	Raf	-0.151274324677221	875.395343987362	20	95.2362827983517	1	0	0
10	17	Activin	Ras	-0.151274324677221	875.395343987362	20	95.2362827983517	1	0	0
11	34	Actr	Mek	-0.152158078351239	875.399966538021	20	95.2316602476924	1	0	0
12	37	Actr	Raf	-0.152158078351239	875.399966538021	20	95.2316602476924	1	0	0
13	38	Actr	Ras	-0.152158078351239	875.399966538021	20	95.2316602476924	1	0	0
14	6	Activin	Erk	-1	876.19068593168	20	94.4409408540336	1	0	0
15	29	Actr	Fgfr	-0.109752810948281	877.033681514489	20	93.5979452712244	1	0	0
16	8	Activin	Fgfr	-0.109518819568173	877.036627479454	20	93.5949993062593	1	0	0
17	386	Smad2	Fgfr	-0.100000068381778	880.738339407433	20	89.8932873782805	1	0	0
18	96	Bmp4r	Lifr	146.293823633502	890.206270302285	21	80.4253564834291	2	0	0
19	95	Bmp4r	Jak	100.000000025193	893.519609105346	21	77.1120176803679	2	0	0
20	391	Smad2	Mek	-0.1	894.495720617054	20	76.1359061686597	1	0	0

LA3:Bmp4r->Fgfr

Model residual = 867

Link Extension :

	adj_idx	from	to	value	residual	df	Res_delta	df_delta	pval	adj_pval
1	268	Mek	Raf	-6.48420744953439	611.484728447621	22	255.595399126098	1	0	0
2	269	Mek	Ras	-6.48503235451705	611.486413053196	22	255.593714520524	1	0	0
3	122	Erk	Ras	-1.42993730891105	611.600929146642	22	255.479198427077	1	0	0
4	118	Erk	Mek	-1.42955753822242	611.628079213488	22	255.452048360232	1	0	0
5	121	Erk	Raf	-1.42912374969748	611.673124799125	22	255.407002774595	1	0	0
6	103	Bmp4r	Smad2	0.875965322102496	785.739608677576	22	81.3405188961431	1	0	0
7	86	Bmp4r	Actr	0.876416426590895	785.740483861214	22	81.3396437125058	1	0	0
8	359	Smad1	Actr	1	786.308377696311	22	80.771749877409	1	0	0
9	376	Smad1	Smad2	1	786.308377696828	22	80.7717498768917	1	0	0
10	149	Fgfr	Actr	0.970685060228157	800.239457835563	22	66.8406697381567	1	3.33066907387547e-16	1.13242748511766e-13
11	166	Fgfr	Smad2	0.970685071593034	800.239457957286	22	66.8406696164333	1	3.33066907387547e-16	1.13242748511766e-13
12	355	Ras	Smad2	0.887689724088292	800.259729677718	22	66.8203978960014	1	3.33066907387547e-16	1.13242748511766e-13
13	317	Raf	Actr	0.887689712593608	800.259729708413	22	66.8203978653063	1	3.33066907387547e-16	1.13242748511766e-13
14	334	Raf	Smad2	0.887689699306619	800.259729744808	22	66.8203978289113	1	3.33066907387547e-16	1.13242748511766e-13
15	338	Ras	Actr	0.887689698278604	800.259729746685	22	66.820397827035	1	3.33066907387547e-16	1.13242748511766e-13
16	219	Jak	Gsk3	0.0954023991913973	807.47789398697	22	59.60223358675	1	1.16573417585641e-14	3.96349619791179e-12
17	408	Stat3	Gsk3	0.116250550747157	807.477895558946	22	59.6022320147737	1	1.16573417585641e-14	3.96349619791179e-12
18	113	Erk	Fgfr	-1.5175149811288	807.595214138194	22	59.4849134355252	1	1.23234755733392e-14	4.18998169493533e-12
19	260	Mek	Fgfr	-5.97670693702218	807.595214433142	22	59.484913140578	1	1.23234755733392e-14	4.18998169493533e-12
20	110	Erk	Bmp4r	-0.000225633437653167	807.599122894852	22	59.4810046788676	1	1.23234755733392e-14	4.18998169493533e-12

LA4:Erk->Raf

Model residual = 611

Link Extension :

	adj_idx	from	to	value	residual	df	Res_delta	df_delta	pval	adj_pval
1	86	Bmp4r	Actr	1	538.054691994744	23	73.4266896923361	1	0	0
2	103	Bmp4r	Smad2	1	538.054691994744	23	73.4266896923361	1	0	0
3	338	Ras	Actr	0.972501250488619	545.487280932185	23	65.9941007548952	1	4.44089209850063e-16	1.50546242139171e-13
4	355	Ras	Smad2	0.972436848502515	545.489382476489	23	65.9919992105911	1	4.44089209850063e-16	1.50546242139171e-13
5	408	Stat3	Gsk3	0.11645328055495	547.331781154314	23	64.1496005327663	1	1.11022302462516e-15	3.76365605347929e-13
6	219	Jak	Gsk3	0.097227252336912	547.331783332299	23	64.1495983547812	1	1.11022302462516e-15	3.76365605347929e-13
7	414	Stat3	Pi3k	0.00223319697700812	550.103433577891	23	61.3779481091896	1	4.66293670342566e-15	1.5807355424613e-12
8	225	Jak	Pi3k	0.00814337884241785	550.116268160372	23	61.3651135267081	1	4.77395900588817e-15	1.61837210299609e-12
9	220	Jak	Igfr	0.00147940987131239	550.139649856149	23	61.3417318309314	1	4.77395900588817e-15	1.61837210299609e-12
10	409	Stat3	Igfr	0.00133333310152612	550.150826676615	23	61.3305550104649	1	4.77395900588817e-15	1.61837210299609e-12
11	213	Jak	Akt	0.000326884318160387	550.170695575493	23	61.310686111587	1	4.88498130835069e-15	1.65600866353088e-12
12	402	Stat3	Akt	0.000681745589889224	550.173491284069	23	61.3078904030116	1	4.88498130835069e-15	1.65600866353088e-12
13	149	Fgfr	Actr	0.999999999999996	551.103681406195	23	60.3777002808851	1	7.88258347483861e-15	2.67219579797029e-12
14	166	Fgfr	Smad2	0.999999999999996	551.103681406195	23	60.3777002808849	1	7.88258347483861e-15	2.67219579797029e-12
15	107	Erk	Actr	0.126706984182453	552.877015400509	23	58.6043662865713	1	1.93178806284777e-14	6.54876153305394e-12
16	124	Erk	Smad2	0.126697788192819	552.877929597554	23	58.6034520895264	1	1.93178806284777e-14	6.54876153305394e-12
17	254	Mek	Actr	0.59438460540211	552.893586778656	23	58.5877949084241	1	1.94289029309402e-14	6.58639809358873e-12
18	271	Mek	Smad2	0.594390267384607	552.894447059316	23	58.5869346277639	1	1.94289029309402e-14	6.58639809358873e-12
19	415	Stat3	Raf	-5.39253521231173	553.106579027843	23	58.3748026592369	1	2.16493489801906e-14	7.33912930428461e-12
20	227	Jak	Ras	-4.20013840049262	553.491954053355	23	57.9894276337252	1	2.63122856836162e-14	8.91986484674589e-12

LA5:Jak ->Gsk3

Model residual = 547

Link Extension :

	adj_idx	from	to	value	residual	df	Res_delta	df_delta	pval	adj_pval
1	86	Bmp4r	Actr	1.34506065680717	465.989068796561	24	81.34271123274	1	0	0
2	103	Bmp4r	Smad2	1.34504409171201	465.989068797419	24	81.3427112318826	1	0	0
3	376	Smad1	Smad2	1	465.989068824412	24	81.3427112048893	1	0	0
4	359	Smad1	Actr	1	465.989068827716	24	81.3427112015858	1	0	0
5	166	Fgfr	Smad2	0.787374824949833	487.061033975627	24	60.270746053674	1	8.21565038222616e-15	2.77688982919244e-12
6	338	Ras	Actr	0.787455359343572	487.061033993199	24	60.2707460361019	1	8.21565038222616e-15	2.77688982919244e-12
7	355	Ras	Smad2	0.787502733552122	487.061034044346	24	60.2707459849557	1	8.21565038222616e-15	2.77688982919244e-12
8	149	Fgfr	Actr	0.787361722517166	487.061034176801	24	60.2707458525001	1	8.21565038222616e-15	2.77688982919244e-12
9	254	Mek	Actr	0.543845407260371	493.382475651737	24	53.9493043775648	1	2.05724326463042e-13	6.95348223445082e-11
10	271	Mek	Smad2	0.543845594194931	493.382475743574	24	53.9493042857273	1	2.05724326463042e-13	6.95348223445082e-11
11	107	Erk	Actr	0.123251772849866	493.382475913176	24	53.9493041161249	1	2.05724326463042e-13	6.95348223445082e-11
12	124	Erk	Smad2	0.123252011763697	493.382475950772	24	53.9493040785295	1	2.05724326463042e-13	6.95348223445082e-11
13	179	Gsk3	Jak	0.254057940252951	498.90101774214	24	48.4307622871614	1	3.42159633959227e-12	1.15649956278219e-09
14	180	Gsk3	Lifr	0.254068705210873	498.901018202538	24	48.4307618267629	1	3.42159633959227e-12	1.15649956278219e-09
15	200	Igfr	Jak	0.39468277779385	502.069366179668	24	45.2624138496332	1	1.72324376990218e-11	5.82456394226937e-09
16	201	Igfr	Lifr	0.394481641402181	502.06936628535	24	45.262413743951	1	1.72324376990218e-11	5.82456394226937e-09
17	8	Activin	Fgfr	-0.0929446875223427	502.642865707683	24	44.6889143216187	1	2.30960806035796e-11	7.8064752440099e-09
18	29	Actr	Fgfr	-0.0929454245928924	502.642865730224	24	44.6889142990776	1	2.30960806035796e-11	7.8064752440099e-09
19	386	Smad2	Fgfr	-0.119228947142523	502.642865778709	24	44.6889142505922	1	2.30960806035796e-11	7.8064752440099e-09
20	383	Smad2	Bmp4r	-0.000503740399463089	502.643770899251	24	44.68800913005	1	2.31068497669185e-11	7.81011522121845e-09

LA6:Bmp4r->Smad2

Model residual = 466

Link Extension :

	adj_idx	from	to	value	residual	df	Res_delta	df_delta	pval	adj_pval
1	180	Gsk3	Lifr	0.254065052403451	417.558306751425	25	48.4307620559355	1	3.42159633959227e-12	1.15307796644259e-09
2	179	Gsk3	Jak	0.254066047918223	417.558306885212	25	48.4307619221488	1	3.42159633959227e-12	1.15307796644259e-09
3	200	Igfr	Jak	0.394692223232032	420.726654328766	25	45.2624144785951	1	1.72324376990218e-11	5.80733150457035e-09
4	201	Igfr	Lifr	0.394595483955924	420.726654602669	25	45.2624142046917	1	1.72324376990218e-11	5.80733150457035e-09
5	29	Actr	Fgfr	-0.0929448139068522	421.300154434767	25	44.6889143725937	1	2.30960806035796e-11	7.78337916340632e-09
6	386	Smad2	Fgfr	-0.0994359792194196	421.300154441298	25	44.6889143660631	1	2.30960806035796e-11	7.78337916340632e-09
7	8	Activin	Fgfr	-0.0929473638282564	421.300154452023	25	44.6889143553376	1	2.30960806035796e-11	7.78337916340632e-09
8	383	Smad2	Bmp4r	-6.6538659223381e-05	421.301339789439	25	44.6877290179215	1	2.31100694136899e-11	7.7880933924135e-09
9	382	Smad2	Bmp4	1	421.3013402415	25	44.6877285658604	1	2.31100694136899e-11	7.7880933924135e-09
10	26	Actr	Bmp4r	-0.000140141598918061	421.302820080091	25	44.6862487272697	1	2.3127610937479e-11	7.79400488593042e-09
11	25	Actr	Bmp4	-0.00014013479222055	421.302822167555	25	44.686246639806	1	2.3127610937479e-11	7.79400488593042e-09
12	4	Activin	Bmp4	-0.000140135265512838	421.302822175243	25	44.686246632118	1	2.3127610937479e-11	7.79400488593042e-09
13	5	Activin	Bmp4r	-0.000140143616979495	421.302822295164	25	44.6862465121964	1	2.3127610937479e-11	7.79400488593042e-09
14	394	Smad2	Raf	-0.823997710128468	422.178358548019	25	43.8107102593414	1	3.61720653430098e-11	1.21899860205943e-08
15	395	Smad2	Ras	-0.823997776732209	422.178358549224	25	43.8107102581371	1	3.61720653430098e-11	1.21899860205943e-08
16	391	Smad2	Mek	-0.823997262369139	422.178358550684	25	43.8107102566772	1	3.61720653430098e-11	1.21899860205943e-08
17	13	Activin	Mek	-0.766281802333446	422.577980559772	25	43.4110882475888	1	4.43667325100705e-11	1.49515888558938e-08
18	16	Activin	Raf	-0.766281802333446	422.577980559772	25	43.4110882475888	1	4.43667325100705e-11	1.49515888558938e-08
19	17	Activin	Ras	-0.766281802333446	422.577980559772	25	43.4110882475888	1	4.43667325100705e-11	1.49515888558938e-08
20	34	Actr	Mek	-0.766282409199382	422.5779805724	25	43.411088234961	1	4.43667325100705e-11	1.49515888558938e-08

LA7:Actr->Bmp4r

Model residual = 421

Link Extension :

	adj_idx	from	to	value	residual	df	Res_delta	df_delta	pval	adj_pval
1	180	Gsk3	Lifr	0.198638973271869	385.047283318677	26	36.25473399488	1	1.73138925418925e-09	5.81746789407588e-07
2	179	Gsk3	Jak	0.198636048215218	385.047294407416	26	36.2547229061416	1	1.73139913517417e-09	5.81750109418521e-07
3	188	Gsk3	Stat3	0.155300697027229	387.3530474701	26	33.9489698434573	1	5.65766333782136e-09	1.90097488150798e-06
4	201	Igfr	Lifr	0.348512997176483	388.891352120685	26	32.4106651928718	1	1.24799656164853e-08	4.19326844713906e-06
5	200	Igfr	Jak	0.3485124279963	388.891354814541	26	32.410662499016	1	1.24799828249422e-08	4.19327422918058e-06
6	209	Igfr	Stat3	0.248199280468535	392.773026133605	26	28.5289911799522	1	9.23059626511957e-08	3.10148034508018e-05
7	234	Lifr	Akt	0.0465599314232042	395.083809486956	26	26.218207826601	1	3.04933785444383e-07	0.000102457751909313
8	276	NoLif	Akt	0.0465600006314084	395.083857290837	26	26.2181600227203	1	3.04941334072772e-07	0.000102460288248451
9	241	Lifr	Igfr	0.134000793526346	395.630083197019	26	25.671934116538	1	4.04669677656067e-07	0.000135969011692439
10	283	NoLif	Igfr	0.134140540681871	395.630097546065	26	25.6719197674927	1	4.04672686582508e-07	0.000135970022691723
11	246	Lifr	Pi3k	137.800332148298	395.7374828565	26	25.5645344570572	1	4.27831139848678e-07	0.000143751262989156
12	288	NoLif	Pi3k	133.859965121113	395.737486643141	26	25.5645306704158	1	4.27831979510351e-07	0.000143751545115478
13	240	Lifr	Gsk3	0.122823623661381	395.921691108318	26	25.3803262052391	1	4.70694108578584e-07	0.000158153220482404
14	282	NoLif	Gsk3	0.122821863643751	395.921738752211	26	25.380278561346	1	4.70705733834897e-07	0.000158157126568525
15	54	Akt	Lifr	0.56618882474856	397.020494865756	26	24.2815224478009	1	8.32336903400233e-07	0.000279665199542478
16	431	mTor	Jak	0.465337458856917	397.020496692259	26	24.2815206212979	1	8.32337692657781e-07	0.000279665464733014
17	432	mTor	Lifr	0.465338156421058	397.020501062787	26	24.2815162507699	1	8.32339581258168e-07	0.000279666099302744
18	53	Akt	Jak	0.566149713542637	397.020501600915	26	24.2815157126425	1	8.32339813849892e-07	0.000279666177453564
19	305	Pi3k	Jak	0.00173202223928323	397.020638990924	26	24.2813783226333	1	8.32399185357602e-07	0.000279686126280154
20	306	Pi3k	Lifr	0.000622528208386818	397.020652026436	26	24.281365287121	1	8.32404818740251e-07	0.000279688019096724

Link_Selection

Init

XX : List post filter

	adj_idx	from	to	value	residual	df	Res_delta	df_delta	pval	adj_pval	Link	Base_Res	Perc_Res_delta
1	178	Gsk3	Igfr	1.41702633999479	1277.72293709044	18	778.579	2	0	0	Gsk3_Igfr	2056.30193709044	37.86
2	171	Gsk3	Akt	1.99559218209568	1288.71968912995	18	767.582	2	0	0	Gsk3_Akt	2056.30168912995	37.33
3	183	Gsk3	Pi3k	15.0727241980515	1289.13219166705	18	767.169	2	0	0	Gsk3_Pi3k	2056.30119166705	37.31
4	176	Gsk3	Fgfr	0.191531955466209	1372.05906755829	18	684.242	2	0	0	Gsk3_Fgfr	2056.30106755829	33.28
5	220	Jak	Igfr	0.0556087755678092	1503.11324628534	17	553.188	1	0	0	Jak_Igfr	2056.30124628534	26.9
6	218	Jak	Fgfr	0.0167866219398153	1515.31854382928	17	540.983	1	0	0	Jak_Fgfr	2056.30154382928	26.31
7	225	Jak	Pi3k	0.386430781716265	1519.02257765008	17	537.279	1	0	0	Jak_Pi3k	2056.30157765008	26.13
8	213	Jak	Akt	0.0299202958574827	1523.34265280937	17	532.959	1	0	0	Jak_Akt	2056.30165280937	25.92
9	92	Bmp4r	Fgfr	100.000006308235	1854.77449547632	18	201.527	2	0	0	Bmp4r_Fgfr	2056.30149547632	9.8
10	29	Actr	Fgfr	-0.792450311159814	1894.64741080012	17	161.654	1	0	0	Actr_Fgfr	2056.30141080012	7.86
11	27	Actr	Erk	-0.753277209074847	1908.45360160677	17	147.848	1	0	0	Actr_Erk	2056.30160160677	7.19
12	34	Actr	Mek	-0.179931092631044	1930.52896307973	17	125.773	1	0	0	Actr_Mek	2056.30196307973	6.12
13	37	Actr	Raf	-0.179931092631044	1930.52896307973	17	125.773	1	0	0	Actr_Raf	2056.30196307973	6.12
14	38	Actr	Ras	-0.179931092631044	1930.52896307973	17	125.773	1	0	0	Actr_Ras	2056.30196307973	6.12
15	90	Bmp4r	Erk	1.00254227701165	1945.00798062694	18	111.293	2	0	0	Bmp4r_Erk	2056.30098062694	5.41
16	94	Bmp4r	Igfr	0.195835877555398	1946.07972998386	18	110.222	2	0	0	Bmp4r_Igfr	2056.30172998386	5.36
17	241	Lifr	Igfr	-8.64959120556414	1951.984753853	17	104.317	1	0	0	Lifr_Igfr	2056.301753853	5.07
18	99	Bmp4r	Pi3k	0.099135408617148	1952.17922272236	18	104.122	2	0	0	Bmp4r_Pi3k	2056.30122272236	5.06
19	87	Bmp4r	Akt	10.0000009020694	1957.94804413658	18	98.353	2	0	0	Bmp4r_Akt	2056.30104413658	4.78
20	246	Lifr	Pi3k	-33.0916817789231	1962.46600501336	17	93.835	1	0	0	Lifr_Pi3k	2056.30100501336	4.56

XO : List post filter

	adj_idx	from	to	value	residual	df	Res_delta	df_delta	pval	adj_pval	Link	Base_Res	Perc_Res_delta
1	218	Jak	Fgfr	20.4555622071971	1087.3433154512	17	516.38	1	0	0	Jak_Fgfr	1603.7233154512	32.2
2	216	Jak	Erk	0.694604520012992	1259.70107127078	17	344.022	1	0	0	Jak_Erk	1603.72307127078	21.45
3	223	Jak	Mek	0.15351221946598	1274.91766666864	17	328.806	1	0	0	Jak_Mek	1603.72366666864	20.5
4	226	Jak	Raf	0.15351221946598	1274.91766666864	17	328.806	1	0	0	Jak_Raf	1603.72366666864	20.5
5	227	Jak	Ras	0.15351221946598	1274.91766666864	17	328.806	1	0	0	Jak_Ras	1603.72366666864	20.5
6	239	Lifr	Fgfr	-22.8862756816318	1284.20827339159	17	319.515	1	0	0	Lifr_Fgfr	1603.72327339159	19.92
7	237	Lifr	Erk	-1.09664060760853	1307.81404086072	17	295.909	1	0	0	Lifr_Erk	1603.72304086072	18.45
8	244	Lifr	Mek	-0.239871706973556	1311.08678087424	17	292.637	1	0	0	Lifr_Mek	1603.72378087424	18.25
9	247	Lifr	Raf	-0.239871706973556	1311.08678087424	17	292.637	1	0	0	Lifr_Raf	1603.72378087424	18.25
10	248	Lifr	Ras	-0.239871706973556	1311.08678087424	17	292.637	1	0	0	Lifr_Ras	1603.72378087424	18.25
11	220	Jak	Igfr	0.444980919815384	1339.66671380804	17	264.057	1	0	0	Jak_Igfr	1603.72371380804	16.47
12	225	Jak	Pi3k	23.8145409083589	1343.76983210708	17	259.954	1	0	0	Jak_Pi3k	1603.72383210708	16.21
13	213	Jak	Akt	0.100341243030155	1355.56166278988	17	248.162	1	0	0	Jak_Akt	1603.72366278988	15.47
14	118	Erk	Mek	-0.964630137460665	1360.97895223146	17	242.744	1	0	0	Erk_Mek	1603.72295223146	15.14
15	121	Erk	Raf	-0.964630137460665	1360.97895223146	17	242.744	1	0	0	Erk_Raf	1603.72295223146	15.14
16	122	Erk	Ras	-0.964630137460665	1360.97895223146	17	242.744	1	0	0	Erk_Ras	1603.72295223146	15.14
17	268	Mek	Raf	-3.7643708653117	1360.97895223946	17	242.744	1	0	0	Mek_Raf	1603.72295223946	15.14
18	269	Mek	Ras	-3.76437183759911	1360.97895224393	17	242.744	1	0	0	Mek_Ras	1603.72295224393	15.14
19	219	Jak	Gsk3	0.309068043959635	1379.30411367602	17	224.419	1	0	0	Jak_Gsk3	1603.72311367602	13.99
20	92	Bmp4r	Fgfr	10.0002449611418	1416.66260952319	18	187.061	2	0	0	Bmp4r_Fgfr	1603.72360952319	11.66

Intersection List

	Link	Res_delta_XX	adj_pval_XX	Perc_Res_delta_XX	Res_delta_XO	adj_pval_XO	Perc_Res_delta_XO	Total_DelResidual	Tot_Percentage_DelResidual
6	Jak_Fgfr	540.983	0	26.31	516.38	0	32.2	1057.363	58.51
1	Gsk3_Igfr	778.579	0	37.86	136.041	0	8.48	914.62	46.34
3	Gsk3_Pi3k	767.169	0	37.31	132.95	0	8.29	900.119	45.6
2	Gsk3_Akt	767.582	0	37.33	130.764	0	8.15	898.346	45.48
5	Jak_Igfr	553.188	0	26.9	264.057	0	16.47	817.245	43.37
7	Jak_Pi3k	537.279	0	26.13	259.954	0	16.21	797.233	42.34
4	Gsk3_Fgfr	684.242	0	33.28	136.041	0	8.48	820.283	41.76
8	Jak_Akt	532.959	0	25.92	248.162	0	15.47	781.121	41.39
26	Jak_Erk	83.477	0	4.06	344.022	0	21.45	427.499	25.51
21	Lifr_Fgfr	89.61	0	4.36	319.515	0	19.92	409.125	24.28
27	Jak_Mek	67.087	0	3.26	328.806	0	20.5	395.893	23.76
28	Jak_Raf	67.087	0	3.26	328.806	0	20.5	395.893	23.76
29	Jak_Ras	67.087	0	3.26	328.806	0	20.5	395.893	23.76
9	Bmp4r_Fgfr	201.527	0	9.8	187.061	0	11.66	388.588	21.46
10	Actr_Fgfr	161.654	0	7.86	184.891	0	11.53	346.545	19.39
11	Actr_Erk	147.848	0	7.19	159.145	0	9.92	306.993	17.11
36	Mek_Raf	34.936	0	1.7	242.744	0	15.14	277.68	16.84
37	Mek_Ras	34.936	0	1.7	242.744	0	15.14	277.68	16.84
38	Erk_Mek	34.936	0	1.7	242.744	0	15.14	277.68	16.84
39	Erk_Raf	34.936	0	1.7	242.744	0	15.14	277.68	16.84

LA1

XX : List post filter

	adj_idx	from	to	value	residual	df	Res_delta	df_delta	pval	adj_pval	Link	Base_Res	Perc_Res_delta
1	178	Gsk3	Igfr	1.07092508964865	971.812846969374	19	543.189	2	0	0	Gsk3_Igfr	1515.00184696937	35.85
2	171	Gsk3	Akt	1.68236052914573	980.75472533061	19	534.247	2	0	0	Gsk3_Akt	1515.00172533061	35.26
3	183	Gsk3	Pi3k	0.947902586974397	981.104897412239	19	533.897	2	0	0	Gsk3_Pi3k	1515.00189741224	35.24
4	176	Gsk3	Fgfr	0.0366456344380372	1042.9909365935	19	472.011	2	0	0	Gsk3_Fgfr	1515.0019365935	31.16
5	179	Gsk3	Jak	3.57901785216984	1186.00515881884	19	328.997	2	0	0	Gsk3_Jak	1515.00215881884	21.72
6	180	Gsk3	Lifr	3.57012904221758	1186.0051592358	19	328.997	2	0	0	Gsk3_Lifr	1515.0021592358	21.72
7	92	Bmp4r	Fgfr	100.000000018277	1379.2932137683	19	135.709	2	0	0	Bmp4r_Fgfr	1515.0022137683	8.96
8	96	Bmp4r	Lifr	13.860198582644	1405.40002957656	19	109.602	2	0	0	Bmp4r_Lifr	1515.00202957656	7.23
9	95	Bmp4r	Jak	10.0003455473115	1405.40002968353	19	109.602	2	0	0	Bmp4r_Jak	1515.00202968353	7.23
10	90	Bmp4r	Erk	0.0999812891114909	1409.88137320982	19	105.121	2	0	0	Bmp4r_Erk	1515.00237320982	6.94
11	27	Actr	Erk	-0.615066582280294	1431.05413356246	18	83.948	1	0	0	Actr_Erk	1515.00213356246	5.54
12	97	Bmp4r	Mek	0.0950267626764539	1432.52845502105	19	82.474	2	0	0	Bmp4r_Mek	1515.00245502105	5.44
13	100	Bmp4r	Raf	0.0950267626764539	1432.52845502105	19	82.474	2	0	0	Bmp4r_Raf	1515.00245502105	5.44
14	101	Bmp4r	Ras	0.0950267626764539	1432.52845502105	19	82.474	2	0	0	Bmp4r_Ras	1515.00245502105	5.44
15	220	Jak	Igfr	0.368915097530597	1435.74303261254	18	79.259	1	0	0	Jak_Igfr	1515.00203261254	5.23
16	29	Actr	Fgfr	-0.183054053565317	1436.60116940405	18	78.401	1	0	0	Actr_Fgfr	1515.00216940405	5.17
17	262	Mek	Igfr	4.08398310958696	1443.43775345878	18	71.564	1	0	0	Mek_Igfr	1515.00175345878	4.72
18	115	Erk	Igfr	1.20036285529175	1443.43775367973	18	71.564	1	0	0	Erk_Igfr	1515.00175367973	4.72
19	34	Actr	Mek	-0.138837756484627	1447.09755458941	18	67.904	1	2.22044604925031e-16	0	Actr_Mek	1515.00155458941	4.48
20	37	Actr	Raf	-0.138837756484627	1447.09755458941	18	67.904	1	2.22044604925031e-16	0	Actr_Raf	1515.00155458941	4.48

XO : List post filter

	adj_idx	from	to	value	residual	df	Res_delta	df_delta	pval	adj_pval	Link	Base_Res	Perc_Res_delta
1	118	Erk	Mek	-1.3134031405681	815.631614385471	18	247.924	1	0	0	Erk_Mek	1063.55561438547	23.31
2	121	Erk	Raf	-1.3134031405681	815.631614385471	18	247.924	1	0	0	Erk_Raf	1063.55561438547	23.31
3	122	Erk	Ras	-1.3134031405681	815.631614385471	18	247.924	1	0	0	Erk_Ras	1063.55561438547	23.31
4	269	Mek	Ras	-5.83516557728466	815.631614406535	18	247.924	1	0	0	Mek_Ras	1063.55561440654	23.31
5	268	Mek	Raf	-5.83501103034113	815.631614489309	18	247.924	1	0	0	Mek_Raf	1063.55561448931	23.31
6	92	Bmp4r	Fgfr	9.99999909080412	953.75112000258	19	109.805	2	0	0	Bmp4r_Fgfr	1063.55612000258	10.32
7	29	Actr	Fgfr	-0.107633817589381	960.885942690023	18	102.67	1	0	0	Actr_Fgfr	1063.55594269002	9.65
8	97	Bmp4r	Mek	99.9999999996109	962.159252464793	19	101.397	2	0	0	Bmp4r_Mek	1063.55625246479	9.53
9	100	Bmp4r	Raf	99.9999999996109	962.159252464793	19	101.397	2	0	0	Bmp4r_Raf	1063.55625246479	9.53
10	101	Bmp4r	Ras	99.9999999996109	962.159252464793	19	101.397	2	0	0	Bmp4r_Ras	1063.55625246479	9.53
11	179	Gsk3	Jak	0.109872274801102	962.880760353095	19	100.675	2	0	0	Gsk3_Jak	1063.55576035309	9.47
12	180	Gsk3	Lifr	0.109861109481093	962.880760387493	19	100.675	2	0	0	Gsk3_Lifr	1063.55576038749	9.47
13	90	Bmp4r	Erk	1.00643342523252	964.022333976477	19	99.534	2	0	0	Bmp4r_Erk	1063.55633397648	9.36
14	27	Actr	Erk	-0.763289910081632	964.487926033674	18	99.068	1	0	0	Actr_Erk	1063.55592603367	9.31
15	34	Actr	Mek	-0.150168259323638	966.972716750091	18	96.583	1	0	0	Actr_Mek	1063.55571675009	9.08
16	37	Actr	Raf	-0.150168259323638	966.972716750091	18	96.583	1	0	0	Actr_Raf	1063.55571675009	9.08
17	38	Actr	Ras	-0.150168259323638	966.972716750091	18	96.583	1	0	0	Actr_Ras	1063.55571675009	9.08
18	178	Gsk3	Igfr	1.30183596917892	970.633324505165	19	92.923	2	0	0	Gsk3_Igfr	1063.55632450516	8.74
19	171	Gsk3	Akt	0.402280553698581	975.233547947986	19	88.322	2	0	0	Gsk3_Akt	1063.55554794799	8.3
20	183	Gsk3	Pi3k	27.7393642323468	975.296728351085	19	88.259	2	0	0	Gsk3_Pi3k	1063.55572835109	8.3

Intersection List

	Link	Res_delta_XX	adj_pval_XX	Perc_Res_delta_XX	Res_delta_XO	adj_pval_XO	Perc_Res_delta_XO	Total_DelResidual	Tot_Percentage_DelResidual
1	Gsk3_Igfr	543.189	0	35.85	92.923	0	8.74	636.112	44.59
2	Gsk3_Akt	534.247	0	35.26	88.322	0	8.3	622.569	43.56
3	Gsk3_Pi3k	533.897	0	35.24	88.259	0	8.3	622.156	43.54
4	Gsk3_Fgfr	472.011	0	31.16	62.94	0	5.92	534.951	37.08
5	Gsk3_Jak	328.997	0	21.72	100.675	0	9.47	429.672	31.19
6	Gsk3_Lifr	328.997	0	21.72	100.675	0	9.47	429.672	31.19
29	Erk_Raf	40.028	0	2.64	247.924	0	23.31	287.952	25.95
30	Erk_Mek	40.028	0	2.64	247.924	0	23.31	287.952	25.95
31	Mek_Ras	40.028	0	2.64	247.924	0	23.31	287.952	25.95
32	Mek_Raf	40.028	0	2.64	247.924	0	23.31	287.952	25.95
33	Erk_Ras	40.028	0	2.64	247.924	0	23.31	287.952	25.95
7	Bmp4r_Fgfr	135.709	0	8.96	109.805	0	10.32	245.514	19.28
10	Bmp4r_Erk	105.121	0	6.94	99.534	0	9.36	204.655	16.3
8	Bmp4r_Lifr	109.602	0	7.23	85.461	0	8.04	195.063	15.27
9	Bmp4r_Jak	109.602	0	7.23	85.461	0	8.04	195.063	15.27
12	Bmp4r_Mek	82.474	0	5.44	101.397	0	9.53	183.871	14.97
13	Bmp4r_Raf	82.474	0	5.44	101.397	0	9.53	183.871	14.97
14	Bmp4r_Ras	82.474	0	5.44	101.397	0	9.53	183.871	14.97
11	Actr_Erk	83.948	0	5.54	99.068	0	9.31	183.016	14.85
16	Actr_Fgfr	78.401	0	5.17	102.67	0	9.65	181.071	14.82

LA2

XX : List post filter

	adj_idx	from	to	value	residual	df	Res_delta	df_delta	pval	adj_pval	Link	Base_Res	Perc_Res_delta
1	92	Bmp4r	Fgfr	100.000000000003	841.461666755043	21	129.337	2	0	0	Bmp4r_Fgfr	970.798666755043	13.32
2	90	Bmp4r	Erk	10.0000192017944	866.760153279043	21	104.038	2	0	0	Bmp4r_Erk	970.798153279043	10.72
3	95	Bmp4r	Jak	10.0001269820917	879.28557415186	21	91.513	2	0	0	Bmp4r_Jak	970.79857415186	9.43
4	96	Bmp4r	Lifr	214.317017758443	883.773260598781	21	87.025	2	0	0	Bmp4r_Lifr	970.798260598781	8.96
5	97	Bmp4r	Mek	1.0052953446443	889.238103252294	21	81.56	2	0	0	Bmp4r_Mek	970.798103252294	8.4
6	100	Bmp4r	Raf	1.0052953446443	889.238103252294	21	81.56	2	0	0	Bmp4r_Raf	970.798103252294	8.4
7	101	Bmp4r	Ras	1.0052953446443	889.238103252294	21	81.56	2	0	0	Bmp4r_Ras	970.798103252294	8.4
8	27	Actr	Erk	-0.327920234741696	899.875257200335	20	70.923	1	0	0	Actr_Erk	970.798257200335	7.31
9	220	Jak	Igfr	5.55539436656802e-05	901.522264003501	20	69.276	1	1.11022302462516e-16	0	Jak_Igfr	970.798264003501	7.14
10	219	Jak	Gsk3	2.62365545377848e-05	903.256424772377	20	67.542	1	2.22044604925031e-16	0	Jak_Gsk3	970.798424772377	6.96
11	213	Jak	Akt	7.21679806108667e-05	903.376234376356	20	67.422	1	2.22044604925031e-16	0	Jak_Akt	970.798234376356	6.95
12	225	Jak	Pi3k	3.34763735789056e-06	903.440683415853	20	67.358	1	2.22044604925031e-16	0	Jak_Pi3k	970.798683415853	6.94
13	34	Actr	Mek	-0.143655120450202	903.646874708811	20	67.152	1	2.22044604925031e-16	0	Actr_Mek	970.798874708811	6.92
14	37	Actr	Raf	-0.143655120450202	903.646874708811	20	67.152	1	2.22044604925031e-16	0	Actr_Raf	970.798874708811	6.92
15	38	Actr	Ras	-0.143655120450202	903.646874708811	20	67.152	1	2.22044604925031e-16	0	Actr_Ras	970.798874708811	6.92
16	223	Jak	Mek	-0.113535332475045	910.700258950734	20	60.098	1	8.99280649946377e-15	0	Jak_Mek	970.798258950734	6.19
17	227	Jak	Ras	-0.113451591250465	910.750797128889	20	60.048	1	9.2148511043888e-15	0	Jak_Ras	970.798797128889	6.19
18	226	Jak	Raf	-0.113451557015329	910.750832177611	20	60.048	1	9.2148511043888e-15	0	Jak_Raf	970.798832177611	6.19
19	29	Actr	Fgfr	-0.0996376218902906	916.8321693499	20	53.966	1	2.03947969623641e-13	0	Actr_Fgfr	970.7981693499	5.56
20	86	Bmp4r	Actr	100	925.364224509752	21	45.434	2	1.36166189435016e-10	0	Bmp4r_Actr	970.798224509752	4.68

XO : List post filter

	adj_idx	from	to	value	residual	df	Res_delta	df_delta	pval	adj_pval	Link	Base_Res	Perc_Res_delta
1	92	Bmp4r	Fgfr	100.000000000769	869.218810406832	21	101.413	2	0	0	Bmp4r_Fgfr	970.631810406832	10.45
2	97	Bmp4r	Mek	100.000000005133	871.46389835036	21	99.168	2	0	0	Bmp4r_Mek	970.63189835036	10.22
3	100	Bmp4r	Raf	100.000000005133	871.46389835036	21	99.168	2	0	0	Bmp4r_Raf	970.63189835036	10.22
4	101	Bmp4r	Ras	100.000000005133	871.46389835036	21	99.168	2	0	0	Bmp4r_Ras	970.63189835036	10.22
5	90	Bmp4r	Erk	100.000000093328	871.627560561552	21	99.004	2	0	0	Bmp4r_Erk	970.631560561552	10.2
6	27	Actr	Erk	-0.754763746009187	872.382026119069	20	98.25	1	0	0	Actr_Erk	970.632026119069	10.12
7	34	Actr	Mek	-0.152158078351239	875.399966538021	20	95.232	1	0	0	Actr_Mek	970.631966538021	9.81
8	37	Actr	Raf	-0.152158078351239	875.399966538021	20	95.232	1	0	0	Actr_Raf	970.631966538021	9.81
9	38	Actr	Ras	-0.152158078351239	875.399966538021	20	95.232	1	0	0	Actr_Ras	970.631966538021	9.81
10	29	Actr	Fgfr	-0.109752810948281	877.033681514489	20	93.598	1	0	0	Actr_Fgfr	970.631681514489	9.64
11	96	Bmp4r	Lifr	146.293823633502	890.206270302285	21	80.425	2	0	0	Bmp4r_Lifr	970.631270302285	8.29
12	95	Bmp4r	Jak	100.000000025193	893.519609105346	21	77.112	2	0	0	Bmp4r_Jak	970.631609105346	7.94
13	260	Mek	Fgfr	-3.92548662162183	916.678497099128	20	53.953	1	2.05280237253191e-13	0	Mek_Fgfr	970.631497099128	5.56
14	113	Erk	Fgfr	-1.05152055649687	916.678503870721	20	53.953	1	2.05280237253191e-13	0	Erk_Fgfr	970.631503870721	5.56
15	32	Actr	Jak	-3.64697909965899	918.840379685867	20	51.791	1	6.17284001691587e-13	0	Actr_Jak	970.631379685867	5.34
16	223	Jak	Mek	-0.679597168394505	919.385339278145	20	51.246	1	8.14792677772402e-13	0	Jak_Mek	970.631339278145	5.28
17	226	Jak	Raf	-0.679920915415589	919.387144134026	20	51.244	1	8.15458811587177e-13	0	Jak_Raf	970.631144134026	5.28
18	227	Jak	Ras	-0.679623805977004	919.388453030054	20	51.243	1	8.1601392309949e-13	0	Jak_Ras	970.631453030054	5.28
19	200	Igfr	Jak	0.607152559111106	924.915321563123	20	45.716	1	1.36680666784628e-11	0	Igfr_Jak	970.631321563123	4.71
20	201	Igfr	Lifr	0.607161455369962	924.915321756189	20	45.716	1	1.36680666784628e-11	0	Igfr_Lifr	970.631321756189	4.71

Intersection List

	Link	Res_delta_XX	adj_pval_XX	Perc_Res_delta_XX	Res_delta_XO	adj_pval_XO	Perc_Res_delta_XO	Total_DelResidual	Tot_Percentage_DelResidual
1	Bmp4r_Fgfr	129.337	0	13.32	101.413	0	10.45	230.75	23.77
2	Bmp4r_Erk	104.038	0	10.72	99.004	0	10.2	203.042	20.92
5	Bmp4r_Mek	81.56	0	8.4	99.168	0	10.22	180.728	18.62
6	Bmp4r_Raf	81.56	0	8.4	99.168	0	10.22	180.728	18.62
7	Bmp4r_Ras	81.56	0	8.4	99.168	0	10.22	180.728	18.62
8	Actr_Erk	70.923	0	7.31	98.25	0	10.12	169.173	17.43
3	Bmp4r_Jak	91.513	0	9.43	77.112	0	7.94	168.625	17.37
4	Bmp4r_Lifr	87.025	0	8.96	80.425	0	8.29	167.45	17.25
13	Actr_Mek	67.152	0	6.92	95.232	0	9.81	162.384	16.73
14	Actr_Raf	67.152	0	6.92	95.232	0	9.81	162.384	16.73
15	Actr_Ras	67.152	0	6.92	95.232	0	9.81	162.384	16.73
19	Actr_Fgfr	53.966	0	5.56	93.598	0	9.64	147.564	15.2
16	Jak_Mek	60.098	0	6.19	51.246	0	5.28	111.344	11.47
17	Jak_Ras	60.048	0	6.19	51.243	0	5.28	111.291	11.47
18	Jak_Raf	60.048	0	6.19	51.244	0	5.28	111.292	11.47
9	Jak_Igfr	69.276	0	7.14	31.196	0	3.21	100.472	10.35
10	Jak_Gsk3	67.542	0	6.96	31.252	0	3.22	98.794	10.18
12	Jak_Pi3k	67.358	0	6.94	31.061	0	3.2	98.419	10.14
11	Jak_Akt	67.422	0	6.95	24.381	0	2.51	91.803	9.46
29	Actr_Jak	25.399	0	2.62	51.791	0	5.34	77.19	7.96

LA3

XX : List post filter

	adj_idx	from	to	value	residual	df	Res_delta	df_delta	pval	adj_pval	Link	Base_Res	Perc_Res_delta
1	213	Jak	Akt	0.000559101694508571	776.613258315932	22	62.177	1	3.10862446895044e-15	0	Jak_Akt	838.790258315932	7.41
2	225	Jak	Pi3k	8.97904410870197e-05	778.167767008921	22	60.622	1	6.88338275267597e-15	0	Jak_Pi3k	838.789767008921	7.23
3	226	Jak	Raf	-3.17320997476433	796.125380312149	22	42.665	1	6.49684750442248e-11	0	Jak_Raf	838.790380312149	5.09
4	223	Jak	Mek	-3.21824554283048	796.307860112286	22	42.482	1	7.13212822134324e-11	0	Jak_Mek	838.789860112286	5.06
5	227	Jak	Ras	-3.24588645068019	796.497908448933	22	42.292	1	7.8599460273665e-11	0	Jak_Ras	838.789908448933	5.04
6	103	Bmp4r	Smad2	100.02186644193	797.416938400438	22	41.373	1	1.25762289471254e-10	0	Bmp4r_Smad2	838.789938400438	4.93
7	86	Bmp4r	Actr	100.010657724698	797.452728577297	22	41.338	1	1.28086097284097e-10	0	Bmp4r_Actr	838.790728577297	4.93
8	27	Actr	Erk	-0.327920237439189	798.210046345649	22	40.58	1	1.88708271231519e-10	0	Actr_Erk	838.790046345649	4.84
9	118	Erk	Mek	-0.0986955651077006	801.650786718166	22	37.139	1	1.09975040185617e-09	0	Erk_Mek	838.789786718166	4.43
10	122	Erk	Ras	-0.0986955651090815	801.650787921435	22	37.139	1	1.09975106798998e-09	0	Erk_Ras	838.789787921435	4.43
11	121	Erk	Raf	-0.0986955651101688	801.650787967443	22	37.139	1	1.09975106798998e-09	0	Erk_Raf	838.789787967443	4.43
12	220	Jak	Igfr	8.04755410748596e-06	803.218989797017	22	35.571	1	2.45887887828644e-09	0	Jak_Igfr	838.789989797017	4.24
13	219	Jak	Gsk3	1.8976668905807e-06	804.236849232934	22	34.553	1	4.14715040086833e-09	0	Jak_Gsk3	838.789849232934	4.12
14	296	Pi3k	Actr	0.0799847924035548	805.648274322902	22	33.142	1	8.56689130745991e-09	0	Pi3k_Actr	838.790274322902	3.95
15	313	Pi3k	Smad2	0.0799847925091786	805.648274330931	22	33.142	1	8.56689130745991e-09	0	Pi3k_Smad2	838.790274330931	3.95
16	44	Akt	Actr	0.114956474981868	805.682679213556	22	33.108	1	8.71982563932505e-09	0	Akt_Actr	838.790679213556	3.95
17	61	Akt	Smad2	0.114956463482465	805.682680922324	22	33.108	1	8.71983329986392e-09	0	Akt_Smad2	838.790680922324	3.95
18	439	mTor	Smad2	0.506699766699231	805.710502414969	22	33.08	1	8.84550099833348e-09	0	mTor_Smad2	838.790502414969	3.94
19	422	mTor	Actr	0.506699424060749	805.710776705229	22	33.079	1	8.84674900003546e-09	0	mTor_Actr	838.789776705229	3.94
20	208	Igfr	Smad2	0.248919176116332	805.745289414332	22	33.045	1	9.00518659641136e-09	0	Igfr_Smad2	838.790289414332	3.94

XO : List post filter

	adj_idx	from	to	value	residual	df	Res_delta	df_delta	pval	adj_pval	Link	Base_Res	Perc_Res_delta
1	268	Mek	Raf	-6.48420744953439	611.484728447621	22	255.595	1	0	0	Mek_Raf	867.079728447621	29.48
2	269	Mek	Ras	-6.48503235451705	611.486413053196	22	255.594	1	0	0	Mek_Ras	867.080413053196	29.48
3	122	Erk	Ras	-1.42993730891105	611.600929146642	22	255.479	1	0	0	Erk_Ras	867.079929146642	29.46
4	118	Erk	Mek	-1.42955753822242	611.628079213488	22	255.452	1	0	0	Erk_Mek	867.080079213488	29.46
5	121	Erk	Raf	-1.42912374969748	611.673124799125	22	255.407	1	0	0	Erk_Raf	867.080124799125	29.46
6	103	Bmp4r	Smad2	0.875965322102496	785.739608677576	22	81.341	1	0	0	Bmp4r_Smad2	867.080608677576	9.38
7	86	Bmp4r	Actr	0.876416426590895	785.740483861214	22	81.34	1	0	0	Bmp4r_Actr	867.080483861214	9.38
8	149	Fgfr	Actr	0.970685060228157	800.239457835563	22	66.841	1	3.33066907387547e-16	0	Fgfr_Actr	867.080457835563	7.71
9	166	Fgfr	Smad2	0.970685071593034	800.239457957286	22	66.841	1	3.33066907387547e-16	0	Fgfr_Smad2	867.080457957286	7.71
10	355	Ras	Smad2	0.887689724088292	800.259729677718	22	66.82	1	3.33066907387547e-16	0	Ras_Smad2	867.079729677718	7.71
11	317	Raf	Actr	0.887689712593608	800.259729708413	22	66.82	1	3.33066907387547e-16	0	Raf_Actr	867.079729708413	7.71
12	334	Raf	Smad2	0.887689699306619	800.259729744808	22	66.82	1	3.33066907387547e-16	0	Raf_Smad2	867.079729744808	7.71
13	338	Ras	Actr	0.887689698278604	800.259729746685	22	66.82	1	3.33066907387547e-16	0	Ras_Actr	867.079729746685	7.71
14	219	Jak	Gsk3	0.0954023991913973	807.47789398697	22	59.602	1	1.16573417585641e-14	0	Jak_Gsk3	867.07989398697	6.87
15	113	Erk	Fgfr	-1.5175149811288	807.595214138194	22	59.485	1	1.23234755733392e-14	0	Erk_Fgfr	867.080214138194	6.86
16	260	Mek	Fgfr	-5.97670693702218	807.595214433142	22	59.485	1	1.23234755733392e-14	0	Mek_Fgfr	867.080214433142	6.86
17	110	Erk	Bmp4r	-0.000225633437653167	807.599122894852	22	59.481	1	1.23234755733392e-14	0	Erk_Bmp4r	867.080122894852	6.86
18	107	Erk	Actr	0.126656810527513	807.796915131121	22	59.283	1	1.36557432028894e-14	0	Erk_Actr	867.079915131121	6.84
19	124	Erk	Smad2	0.126651673457868	807.800025300678	22	59.28	1	1.36557432028894e-14	0	Erk_Smad2	867.080025300678	6.84
20	271	Mek	Smad2	0.583506936563152	807.833207759399	22	59.247	1	1.38777878078145e-14	0	Mek_Smad2	867.080207759399	6.83

Intersection List

	Link	Res_delta_XX	adj_pval_XX	Perc_Res_delta_XX	Res_delta_XO	adj_pval_XO	Perc_Res_delta_XO	Total_DelResidual	Tot_Percentage_DelResidual
9	Erk_Mek	37.139	0	4.43	255.452	0	29.46	292.591	33.89
10	Erk_Ras	37.139	0	4.43	255.479	0	29.46	292.618	33.89
11	Erk_Raf	37.139	0	4.43	255.407	0	29.46	292.546	33.89
6	Bmp4r_Smad2	41.373	0	4.93	81.341	0	9.38	122.714	14.31
7	Bmp4r_Actr	41.338	0	4.93	81.34	0	9.38	122.678	14.31
1	Jak_Akt	62.177	0	7.41	56.91	0	6.56	119.087	13.97
2	Jak_Pi3k	60.622	0	7.23	56.933	0	6.57	117.555	13.8
3	Jak_Raf	42.665	0	5.09	54.53	0	6.29	97.195	11.38
4	Jak_Mek	42.482	0	5.06	54.528	0	6.29	97.01	11.35
5	Jak_Ras	42.292	0	5.04	54.53	0	6.29	96.822	11.33
13	Jak_Gsk3	34.553	0	4.12	59.602	0	6.87	94.155	10.99
12	Jak_Igfr	35.571	0	4.24	56.91	0	6.56	92.481	10.8
28	Fgfr_Actr	23.709	0	2.83	66.841	0	7.71	90.55	10.54
29	Fgfr_Smad2	23.709	0	2.83	66.841	0	7.71	90.55	10.54
8	Actr_Erk	40.58	0	4.84	49.135	0	5.67	89.715	10.51
16	Akt_Actr	33.108	0	3.95	45.705	0	5.27	78.813	9.22
17	Akt_Smad2	33.108	0	3.95	45.706	0	5.27	78.814	9.22
20	Igfr_Smad2	33.045	0	3.94	45.665	0	5.27	78.71	9.21
21	Igfr_Actr	33.039	0	3.94	45.665	0	5.27	78.704	9.21
14	Pi3k_Actr	33.142	0	3.95	45.547	0	5.25	78.689	9.2

LA4

XX : List post filter

	adj_idx	from	to	value	residual	df	Res_delta	df_delta	pval	adj_pval	Link	Base_Res	Perc_Res_delta
1	213	Jak	Akt	0.000707406177266371	737.960495916585	23	60.351	1	7.99360577730113e-15	0	Jak_Akt	798.311495916585	7.56
2	220	Jak	Igfr	5.03600959182369e-05	739.346387831751	23	58.965	1	1.60982338570648e-14	0	Jak_Igfr	798.311387831751	7.39
3	219	Jak	Gsk3	8.91364101617684e-05	739.36887470925	23	58.942	1	1.62092561595273e-14	0	Jak_Gsk3	798.31087470925	7.38
4	225	Jak	Pi3k	0.000323749018200995	739.465644562853	23	58.845	1	1.70974345792274e-14	0	Jak_Pi3k	798.310644562853	7.37
5	86	Bmp4r	Actr	0.1	760.705112213975	23	37.606	1	8.65806981664718e-10	0	Bmp4r_Actr	798.311112213975	4.71
6	103	Bmp4r	Smad2	0.1	760.705112213975	23	37.606	1	8.65806981664718e-10	0	Bmp4r_Smad2	798.311112213975	4.71
7	27	Actr	Erk	-0.327920237444485	761.52862579633	23	36.782	1	1.32075872461002e-09	0	Actr_Erk	798.31062579633	4.61
8	34	Actr	Mek	-0.147675991438342	763.080355755634	23	35.231	1	2.92871626950131e-09	0	Actr_Mek	798.311355755634	4.41
9	37	Actr	Raf	-0.147675991438342	763.080355755634	23	35.231	1	2.92871626950131e-09	0	Actr_Raf	798.311355755634	4.41
10	38	Actr	Ras	-0.147675991438342	763.080355755634	23	35.231	1	2.92871626950131e-09	0	Actr_Ras	798.311355755634	4.41
11	313	Pi3k	Smad2	0.0731215380340072	765.019323945664	23	33.292	1	7.93195686910053e-09	0	Pi3k_Smad2	798.311323945664	4.17
12	296	Pi3k	Actr	0.0731215380385857	765.019323952992	23	33.292	1	7.93195698012283e-09	0	Pi3k_Actr	798.311323952992	4.17
13	208	Igfr	Smad2	0.241198705130075	765.079332485809	23	33.232	1	8.18054357587528e-09	0	Igfr_Smad2	798.311332485809	4.16
14	191	Igfr	Actr	0.241198772831739	765.079352853858	23	33.232	1	8.18062928509278e-09	0	Igfr_Actr	798.311352853858	4.16
15	61	Akt	Smad2	0.115582218277731	765.081920020915	23	33.229	1	8.19143630703678e-09	0	Akt_Smad2	798.310920020915	4.16
16	44	Akt	Actr	0.11554890986298	765.083602077782	23	33.227	1	8.19852497002671e-09	0	Akt_Actr	798.310602077782	4.16
17	187	Gsk3	Smad2	0.247120865441656	765.124860320833	23	33.186	1	8.37433644651497e-09	0	Gsk3_Smad2	798.310860320833	4.16
18	170	Gsk3	Actr	0.246911867653975	765.131120793124	23	33.18	1	8.40134184443286e-09	0	Gsk3_Actr	798.311120793124	4.16
19	53	Akt	Jak	0.276120231261104	772.53993913228	23	25.771	1	3.8440010663443e-07	0	Akt_Jak	798.31093913228	3.23
20	305	Pi3k	Jak	0.176081368463955	772.553960374723	23	25.757	1	3.87202878093795e-07	0	Pi3k_Jak	798.310960374723	3.23

XO : List post filter

	adj_idx	from	to	value	residual	df	Res_delta	df_delta	pval	adj_pval	Link	Base_Res	Perc_Res_delta
1	86	Bmp4r	Actr	1	538.054691994744	23	73.427	1	0	0	Bmp4r_Actr	611.481691994744	12.01
2	103	Bmp4r	Smad2	1	538.054691994744	23	73.427	1	0	0	Bmp4r_Smad2	611.481691994744	12.01
3	338	Ras	Actr	0.972501250488619	545.487280932185	23	65.994	1	4.44089209850063e-16	0	Ras_Actr	611.481280932185	10.79
4	355	Ras	Smad2	0.972436848502515	545.489382476489	23	65.992	1	4.44089209850063e-16	0	Ras_Smad2	611.481382476489	10.79
5	219	Jak	Gsk3	0.097227252336912	547.331783332299	23	64.15	1	1.11022302462516e-15	0	Jak_Gsk3	611.481783332299	10.49
6	225	Jak	Pi3k	0.00814337884241785	550.116268160372	23	61.365	1	4.77395900588817e-15	0	Jak_Pi3k	611.481268160372	10.04
7	220	Jak	Igfr	0.00147940987131239	550.139649856149	23	61.342	1	4.77395900588817e-15	0	Jak_Igfr	611.481649856149	10.03
8	213	Jak	Akt	0.000326884318160387	550.170695575493	23	61.311	1	4.88498130835069e-15	0	Jak_Akt	611.481695575493	10.03
9	149	Fgfr	Actr	0.999999999999996	551.103681406195	23	60.378	1	7.88258347483861e-15	0	Fgfr_Actr	611.481681406195	9.87
10	166	Fgfr	Smad2	0.999999999999996	551.103681406195	23	60.378	1	7.88258347483861e-15	0	Fgfr_Smad2	611.481681406195	9.87
11	107	Erk	Actr	0.126706984182453	552.877015400509	23	58.604	1	1.93178806284777e-14	0	Erk_Actr	611.481015400509	9.58
12	124	Erk	Smad2	0.126697788192819	552.877929597554	23	58.603	1	1.93178806284777e-14	0	Erk_Smad2	611.480929597554	9.58
13	254	Mek	Actr	0.59438460540211	552.893586778656	23	58.588	1	1.94289029309402e-14	0	Mek_Actr	611.481586778656	9.58
14	271	Mek	Smad2	0.594390267384607	552.894447059316	23	58.587	1	1.94289029309402e-14	0	Mek_Smad2	611.481447059316	9.58
15	227	Jak	Ras	-4.20013840049262	553.491954053355	23	57.989	1	2.63122856836162e-14	0	Jak_Ras	611.480954053355	9.48
16	223	Jak	Mek	-4.13026330024292	553.624103730407	23	57.857	1	2.8199664825479e-14	0	Jak_Mek	611.481103730407	9.46
17	226	Jak	Raf	-4.05360082602932	553.771671777469	23	57.71	1	3.04201108747293e-14	0	Jak_Raf	611.481671777469	9.44
18	179	Gsk3	Jak	0.119656073842834	562.645430796745	23	48.836	1	2.78288503352542e-12	0	Gsk3_Jak	611.481430796745	7.99
19	180	Gsk3	Lifr	0.119656628383289	562.645433046035	23	48.836	1	2.78288503352542e-12	0	Gsk3_Lifr	611.481433046035	7.99
20	296	Pi3k	Actr	0.0388793995773065	566.197502392802	23	45.284	1	1.70445879632553e-11	0	Pi3k_Actr	611.481502392802	7.41

Intersection List

	Link	Res_delta_XX	adj_pval_XX	Perc_Res_delta_XX	Res_delta_XO	adj_pval_XO	Perc_Res_delta_XO	Total_DelResidual	Tot_Percentage_DelResidual
3	Jak_Gsk3	58.942	0	7.38	64.15	0	10.49	123.092	17.87
1	Jak_Akt	60.351	0	7.56	61.311	0	10.03	121.662	17.59
2	Jak_Igfr	58.965	0	7.39	61.342	0	10.03	120.307	17.42
4	Jak_Pi3k	58.845	0	7.37	61.365	0	10.04	120.21	17.41
5	Bmp4r_Actr	37.606	0	4.71	73.427	0	12.01	111.033	16.72
6	Bmp4r_Smad2	37.606	0	4.71	73.427	0	12.01	111.033	16.72
27	Ras_Actr	22.461	0.001	2.81	65.994	0	10.79	88.455	13.6
28	Ras_Smad2	22.461	0.001	2.81	65.992	0	10.79	88.453	13.6
23	Fgfr_Actr	24.147	0	3.02	60.378	0	9.87	84.525	12.89
24	Fgfr_Smad2	24.147	0	3.02	60.378	0	9.87	84.525	12.89
7	Actr_Mek	35.231	0	4.41	44.814	0	7.33	80.045	11.74
8	Actr_Raf	35.231	0	4.41	44.814	0	7.33	80.045	11.74
9	Actr_Ras	35.231	0	4.41	44.814	0	7.33	80.045	11.74
10	Pi3k_Smad2	33.292	0	4.17	45.282	0	7.41	78.574	11.58
11	Pi3k_Actr	33.292	0	4.17	45.284	0	7.41	78.576	11.58
12	Igfr_Smad2	33.232	0	4.16	45.251	0	7.4	78.483	11.56
13	Igfr_Actr	33.232	0	4.16	45.251	0	7.4	78.483	11.56
14	Akt_Smad2	33.229	0	4.16	45.28	0	7.4	78.509	11.56
15	Akt_Actr	33.227	0	4.16	45.28	0	7.4	78.507	11.56
16	Gsk3_Smad2	33.186	0	4.16	45.178	0	7.39	78.364	11.55

LA5

XX : List post filter

	adj_idx	from	to	value	residual	df	Res_delta	df_delta	pval	adj_pval	Link	Base_Res	Perc_Res_delta
1	34	Actr	Mek	-0.169510536243249	691.497669974297	24	46.457	1	9.3647312127132e-12	0	Actr_Mek	737.954669974297	6.3
2	37	Actr	Raf	-0.169510524829761	691.497670173476	24	46.457	1	9.3647312127132e-12	0	Actr_Raf	737.954670173476	6.3
3	38	Actr	Ras	-0.169510524829761	691.497670173476	24	46.457	1	9.3647312127132e-12	0	Actr_Ras	737.954670173476	6.3
4	27	Actr	Erk	-0.329216993650508	692.07872455242	24	45.876	1	1.25978116827241e-11	0	Actr_Erk	737.95472455242	6.22
5	86	Bmp4r	Actr	0.1	692.718298841271	24	45.236	1	1.74623648874217e-11	0	Bmp4r_Actr	737.954298841271	6.13
6	103	Bmp4r	Smad2	0.1	692.718298841271	24	45.236	1	1.74623648874217e-11	0	Bmp4r_Smad2	737.954298841271	6.13
7	29	Actr	Fgfr	-0.931701344045143	698.398913256414	24	39.556	1	3.1881031148373e-10	0	Actr_Fgfr	737.954913256414	5.36
8	208	Igfr	Smad2	0.252182901106177	703.801214372991	24	34.154	1	5.09303343942946e-09	0	Igfr_Smad2	737.955214372991	4.63
9	191	Igfr	Actr	0.25201962503734	703.801382643909	24	34.153	1	5.09347386490333e-09	0	Igfr_Actr	737.954382643909	4.63
10	313	Pi3k	Smad2	0.30512095678214	703.822303571833	24	34.132	1	5.14852960264989e-09	0	Pi3k_Smad2	737.954303571833	4.63
11	296	Pi3k	Actr	0.30512095702263	703.822303599494	24	34.132	1	5.14852960264989e-09	0	Pi3k_Actr	737.954303599494	4.63
12	187	Gsk3	Smad2	0.253667914857315	703.846862678593	24	34.108	1	5.21392051755498e-09	0	Gsk3_Smad2	737.954862678593	4.62
13	170	Gsk3	Actr	0.253710860378536	703.847228684446	24	34.108	1	5.21490128857494e-09	0	Gsk3_Actr	737.955228684446	4.62
14	439	mTor	Smad2	0.513028961424221	703.894000572903	24	34.061	1	5.34176891608951e-09	0	mTor_Smad2	737.955000572903	4.62
15	422	mTor	Actr	0.513027303830231	703.894099130928	24	34.061	1	5.34203947744061e-09	0	mTor_Actr	737.955099130928	4.62
16	61	Akt	Smad2	0.117738990295091	703.913397121712	24	34.041	1	5.39528410836709e-09	0	Akt_Smad2	737.954397121712	4.61
17	44	Akt	Actr	0.117751598541854	703.914010526694	24	34.041	1	5.39698519208542e-09	0	Akt_Actr	737.955010526694	4.61
18	317	Raf	Actr	0.40403238554479	705.000526082368	24	32.954	1	9.43539935072124e-09	0	Raf_Actr	737.954526082368	4.47
19	334	Raf	Smad2	1	708.952730831816	24	29.002	1	7.23024873305889e-08	0	Raf_Smad2	737.954730831816	3.93
20	166	Fgfr	Smad2	0.252543285418482	708.979059442361	24	28.976	1	7.3291891000693e-08	0	Fgfr_Smad2	737.955059442361	3.93

XO : List post filter

	adj_idx	from	to	value	residual	df	Res_delta	df_delta	pval	adj_pval	Link	Base_Res	Perc_Res_delta
1	86	Bmp4r	Actr	1.34506065680717	465.989068796561	24	81.343	1	0	0	Bmp4r_Actr	547.332068796561	14.86
2	103	Bmp4r	Smad2	1.34504409171201	465.989068797419	24	81.343	1	0	0	Bmp4r_Smad2	547.332068797419	14.86
3	166	Fgfr	Smad2	0.787374824949833	487.061033975627	24	60.271	1	8.21565038222616e-15	0	Fgfr_Smad2	547.332033975627	11.01
4	338	Ras	Actr	0.787455359343572	487.061033993199	24	60.271	1	8.21565038222616e-15	0	Ras_Actr	547.332033993199	11.01
5	355	Ras	Smad2	0.787502733552122	487.061034044346	24	60.271	1	8.21565038222616e-15	0	Ras_Smad2	547.332034044346	11.01
6	149	Fgfr	Actr	0.787361722517166	487.061034176801	24	60.271	1	8.21565038222616e-15	0	Fgfr_Actr	547.332034176801	11.01
7	254	Mek	Actr	0.543845407260371	493.382475651737	24	53.949	1	2.05724326463042e-13	0	Mek_Actr	547.331475651737	9.86
8	271	Mek	Smad2	0.543845594194931	493.382475743574	24	53.949	1	2.05724326463042e-13	0	Mek_Smad2	547.331475743574	9.86
9	107	Erk	Actr	0.123251772849866	493.382475913176	24	53.949	1	2.05724326463042e-13	0	Erk_Actr	547.331475913176	9.86
10	124	Erk	Smad2	0.123252011763697	493.382475950772	24	53.949	1	2.05724326463042e-13	0	Erk_Smad2	547.331475950772	9.86
11	179	Gsk3	Jak	0.254057940252951	498.90101774214	24	48.431	1	3.42159633959227e-12	0	Gsk3_Jak	547.33201774214	8.85
12	180	Gsk3	Lifr	0.254068705210873	498.901018202538	24	48.431	1	3.42159633959227e-12	0	Gsk3_Lifr	547.332018202538	8.85
13	200	Igfr	Jak	0.39468277779385	502.069366179668	24	45.262	1	1.72324376990218e-11	0	Igfr_Jak	547.331366179668	8.27
14	201	Igfr	Lifr	0.394481641402181	502.06936628535	24	45.262	1	1.72324376990218e-11	0	Igfr_Lifr	547.33136628535	8.27
15	29	Actr	Fgfr	-0.0929454245928924	502.642865730224	24	44.689	1	2.30960806035796e-11	0	Actr_Fgfr	547.331865730224	8.16
16	26	Actr	Bmp4r	-0.000417518501707003	502.643828211024	24	44.688	1	2.31075159007332e-11	0	Actr_Bmp4r	547.331828211024	8.16
17	25	Actr	Bmp4	-0.000417633273419691	502.643828453475	24	44.688	1	2.31075159007332e-11	0	Actr_Bmp4	547.331828453475	8.16
18	34	Actr	Mek	-0.766280755915089	503.920691793538	24	43.411	1	4.43667325100705e-11	0	Actr_Mek	547.331691793538	7.93
19	37	Actr	Raf	-0.766280755915089	503.920691793538	24	43.411	1	4.43667325100705e-11	0	Actr_Raf	547.331691793538	7.93
20	38	Actr	Ras	-0.766280755915089	503.920691793538	24	43.411	1	4.43667325100705e-11	0	Actr_Ras	547.331691793538	7.93

Intersection List

	Link	Res_delta_XX	adj_pval_XX	Perc_Res_delta_XX	Res_delta_XO	adj_pval_XO	Perc_Res_delta_XO	Total_DelResidual	Tot_Percentage_DelResidual
4	Bmp4r_Actr	45.236	0	6.13	81.343	0	14.86	126.579	20.99
5	Bmp4r_Smad2	45.236	0	6.13	81.343	0	14.86	126.579	20.99
17	Fgfr_Smad2	28.976	0	3.93	60.271	0	11.01	89.247	14.94
18	Fgfr_Actr	28.777	0	3.9	60.271	0	11.01	89.048	14.91
1	Actr_Mek	46.457	0	6.3	43.411	0	7.93	89.868	14.23
2	Actr_Raf	46.457	0	6.3	43.411	0	7.93	89.868	14.23
3	Actr_Ras	46.457	0	6.3	43.411	0	7.93	89.868	14.23
6	Actr_Fgfr	39.556	0	5.36	44.689	0	8.16	84.245	13.52
7	Igfr_Smad2	34.154	0	4.63	38.974	0	7.12	73.128	11.75
8	Igfr_Actr	34.153	0	4.63	38.974	0	7.12	73.127	11.75
11	Gsk3_Smad2	34.108	0	4.62	38.911	0	7.11	73.019	11.73
12	Gsk3_Actr	34.108	0	4.62	38.911	0	7.11	73.019	11.73
20	Igfr_Lifr	24.35	0	3.3	45.262	0	8.27	69.612	11.57
21	Igfr_Jak	24.312	0	3.29	45.262	0	8.27	69.574	11.56
9	Pi3k_Smad2	34.132	0	4.63	37.796	0	6.91	71.928	11.54
10	Pi3k_Actr	34.132	0	4.63	37.796	0	6.91	71.928	11.54
13	mTor_Smad2	34.061	0	4.62	37.796	0	6.91	71.857	11.53
14	mTor_Actr	34.061	0	4.62	37.796	0	6.91	71.857	11.53
15	Akt_Smad2	34.041	0	4.61	37.796	0	6.91	71.837	11.52
16	Akt_Actr	34.041	0	4.61	37.796	0	6.91	71.837	11.52

LA6

XX : List post filter

	adj_idx	from	to	value	residual	df	Res_delta	df_delta	pval	adj_pval	Link	Base_Res	Perc_Res_delta
1	27	Actr	Erk	-0.3764990238487	642.112873213278	25	49.77	1	1.72895031624876e-12	0	Actr_Erk	691.882873213278	7.19
2	26	Actr	Bmp4r	-0.114345956401805	651.432322957465	25	40.45	1	2.01689220880041e-10	0	Actr_Bmp4r	691.882322957465	5.85
3	34	Actr	Mek	-0.184466635341531	651.695610071583	25	40.187	1	2.30786167954022e-10	0	Actr_Mek	691.882610071583	5.81
4	37	Actr	Raf	-0.184466635341531	651.695610071583	25	40.187	1	2.30786167954022e-10	0	Actr_Raf	691.882610071583	5.81
5	38	Actr	Ras	-0.184466635341531	651.695610071583	25	40.187	1	2.30786167954022e-10	0	Actr_Ras	691.882610071583	5.81
6	29	Actr	Fgfr	-0.19305395874701	651.86148251821	25	40.021	1	2.51238807535969e-10	0	Actr_Fgfr	691.88248251821	5.78
7	194	Igfr	Bmp4r	9.52513344378078	660.382834653848	25	31.5	1	1.99469695205678e-08	0	Igfr_Bmp4r	691.882834653848	4.55
8	173	Gsk3	Bmp4r	8.35970405891355	662.907058780043	25	28.975	1	7.32999207997409e-08	0	Gsk3_Bmp4r	691.882058780043	4.19
9	25	Actr	Bmp4	-0.0464156641394266	663.78872868241	25	28.094	1	1.15574366854609e-07	0	Actr_Bmp4	691.88272868241	4.06
10	201	Igfr	Lifr	1.04830731184343	667.510464263871	25	24.372	1	7.94111451152268e-07	0	Igfr_Lifr	691.882464263871	3.52
11	54	Akt	Lifr	0.575162428124432	667.568175497793	25	24.314	1	8.18262327006991e-07	0	Akt_Lifr	691.882175497793	3.51
12	200	Igfr	Jak	1.96579482255861	667.587872687412	25	24.295	1	8.26672643783333e-07	0	Igfr_Jak	691.882872687412	3.51
13	53	Akt	Jak	0.436149598416019	667.603179806524	25	24.279	1	8.33268296362988e-07	0	Akt_Jak	691.882179806524	3.51
14	117	Erk	Lifr	0.328160903048842	668.861418427744	25	23.021	1	1.60230636592207e-06	0.001	Erk_Lifr	691.882418427744	3.33
15	263	Mek	Jak	0.737068544088845	668.876713488115	25	23.006	1	1.61510480800597e-06	0.001	Mek_Jak	691.882713488115	3.33
16	264	Mek	Lifr	0.999174471789514	668.992011821064	25	22.891	1	1.71494134126871e-06	0.001	Mek_Lifr	691.883011821064	3.31
17	116	Erk	Jak	0.209038423031387	669.17540261175	25	22.707	1	1.8866499932324e-06	0.001	Erk_Jak	691.88240261175	3.28
18	305	Pi3k	Jak	0.999729227591684	669.279642077345	25	22.603	1	1.99183102189693e-06	0.001	Pi3k_Jak	691.882642077345	3.27
19	179	Gsk3	Jak	0.99909836782814	669.716864297635	25	22.166	1	2.5010441078166e-06	0.001	Gsk3_Jak	691.882864297635	3.2

XO : List post filter

	adj_idx	from	to	value	residual	df	Res_delta	df_delta	pval	adj_pval	Link	Base_Res	Perc_Res_delta
1	180	Gsk3	Lifr	0.254065052403451	417.558306751425	25	48.431	1	3.42159633959227e-12	0	Gsk3_Lifr	465.989306751425	10.39
2	179	Gsk3	Jak	0.254066047918223	417.558306885212	25	48.431	1	3.42159633959227e-12	0	Gsk3_Jak	465.989306885212	10.39
3	200	Igfr	Jak	0.394692223232032	420.726654328766	25	45.262	1	1.72324376990218e-11	0	Igfr_Jak	465.988654328766	9.71
4	201	Igfr	Lifr	0.394595483955924	420.726654602669	25	45.262	1	1.72324376990218e-11	0	Igfr_Lifr	465.988654602669	9.71
5	29	Actr	Fgfr	-0.0929448139068522	421.300154434767	25	44.689	1	2.30960806035796e-11	0	Actr_Fgfr	465.989154434767	9.59
6	26	Actr	Bmp4r	-0.000140141598918061	421.302820080091	25	44.686	1	2.3127610937479e-11	0	Actr_Bmp4r	465.988820080091	9.59
7	25	Actr	Bmp4	-0.00014013479222055	421.302822167555	25	44.686	1	2.3127610937479e-11	0	Actr_Bmp4	465.988822167555	9.59
8	34	Actr	Mek	-0.766282409199382	422.5779805724	25	43.411	1	4.43667325100705e-11	0	Actr_Mek	465.9889805724	9.32
9	37	Actr	Raf	-0.766282409199382	422.5779805724	25	43.411	1	4.43667325100705e-11	0	Actr_Raf	465.9889805724	9.32
10	38	Actr	Ras	-0.766282409199382	422.5779805724	25	43.411	1	4.43667325100705e-11	0	Actr_Ras	465.9889805724	9.32
11	431	mTor	Jak	0.609483208799542	431.486851110413	25	34.502	1	4.25765944722656e-09	0	mTor_Jak	465.988851110413	7.4
12	53	Akt	Jak	0.740863614758909	431.486851123287	25	34.502	1	4.25765955824886e-09	0	Akt_Jak	465.988851123287	7.4
13	54	Akt	Lifr	0.740742211636115	431.486851289899	25	34.502	1	4.25765989131577e-09	0	Akt_Lifr	465.988851289899	7.4
14	432	mTor	Lifr	0.60943205515569	431.48685134728	25	34.502	1	4.25766000233807e-09	0	mTor_Lifr	465.98885134728	7.4
15	306	Pi3k	Lifr	0.0224485932952633	431.486852096483	25	34.502	1	4.25766166767261e-09	0	Pi3k_Lifr	465.988852096483	7.4
16	305	Pi3k	Jak	0.0223468902094113	431.486853872515	25	34.502	1	4.25766555345319e-09	0	Pi3k_Jak	465.988853872515	7.4
17	188	Gsk3	Stat3	0.159954112803069	432.097840299189	25	33.891	1	5.82808634685961e-09	0	Gsk3_Stat3	465.988840299189	7.27
18	194	Igfr	Bmp4r	4.13152048247566	433.320215561465	25	32.669	1	1.09274319592956e-08	0	Igfr_Bmp4r	465.989215561465	7.01
19	193	Igfr	Bmp4	1	433.320218010893	25	32.669	1	1.09274457260611e-08	0	Igfr_Bmp4	465.989218010893	7.01
20	173	Gsk3	Bmp4r	7.27536487596788	436.465612865036	25	29.523	1	5.52440697632051e-08	0	Gsk3_Bmp4r	465.988612865036	6.34

Intersection List

	Link	Res_delta_XX	adj_pval_XX	Perc_Res_delta_XX	Res_delta_XO	adj_pval_XO	Perc_Res_delta_XO	Total_DelResidual	Tot_Percentage_DelResidual
1	Actr_Bmp4r	40.45	0	5.85	44.686	0	9.59	85.136	15.44
5	Actr_Fgfr	40.021	0	5.78	44.689	0	9.59	84.71	15.37
2	Actr_Mek	40.187	0	5.81	43.411	0	9.32	83.598	15.13
3	Actr_Raf	40.187	0	5.81	43.411	0	9.32	83.598	15.13
4	Actr_Ras	40.187	0	5.81	43.411	0	9.32	83.598	15.13
8	Actr_Bmp4	28.094	0	4.06	44.686	0	9.59	72.78	13.65
14	Gsk3_Jak	22.166	0.001	3.2	48.431	0	10.39	70.597	13.59
9	Igfr_Lifr	24.372	0	3.52	45.262	0	9.71	69.634	13.23
11	Igfr_Jak	24.295	0	3.51	45.262	0	9.71	69.557	13.22
6	Igfr_Bmp4r	31.5	0	4.55	32.669	0	7.01	64.169	11.56
10	Akt_Lifr	24.314	0	3.51	34.502	0	7.4	58.816	10.91
12	Akt_Jak	24.279	0	3.51	34.502	0	7.4	58.781	10.91
13	Pi3k_Jak	22.603	0.001	3.27	34.502	0	7.4	57.105	10.67
7	Gsk3_Bmp4r	28.975	0	4.19	29.523	0	6.34	58.498	10.53

LA7

XX : List post filter

	adj_idx	from	to	value	residual	df	Res_delta	df_delta	pval	adj_pval	Link	Base_Res	Perc_Res_delta
1	215	Jak	Bmp4r	0.420445924238593	627.885090183765	26	23.25	1	1.42232177680057e-06	0	Jak_Bmp4r	651.135090183765	3.57

XO : List post filter

	adj_idx	from	to	value	residual	df	Res_delta	df_delta	pval	adj_pval	Link	Base_Res	Perc_Res_delta
1	180	Gsk3	Lifr	0.198638973271869	385.047283318677	26	36.255	1	1.73138925418925e-09	0	Gsk3_Lifr	421.302283318677	8.61
2	179	Gsk3	Jak	0.198636048215218	385.047294407416	26	36.255	1	1.73139913517417e-09	0	Gsk3_Jak	421.302294407416	8.61
3	188	Gsk3	Stat3	0.155300697027229	387.3530474701	26	33.949	1	5.65766333782136e-09	0	Gsk3_Stat3	421.3020474701	8.06
4	201	Igfr	Lifr	0.348512997176483	388.891352120685	26	32.411	1	1.24799656164853e-08	0	Igfr_Lifr	421.302352120685	7.69
5	200	Igfr	Jak	0.3485124279963	388.891354814541	26	32.411	1	1.24799828249422e-08	0	Igfr_Jak	421.302354814541	7.69
6	209	Igfr	Stat3	0.248199280468535	392.773026133605	26	28.529	1	9.23059626511957e-08	0	Igfr_Stat3	421.302026133605	6.77
7	234	Lifr	Akt	0.0465599314232042	395.083809486956	26	26.218	1	3.04933785444383e-07	0	Lifr_Akt	421.301809486956	6.22
8	241	Lifr	Igfr	0.134000793526346	395.630083197019	26	25.672	1	4.04669677656067e-07	0	Lifr_Igfr	421.302083197019	6.09
9	246	Lifr	Pi3k	137.800332148298	395.7374828565	26	25.565	1	4.27831139848678e-07	0	Lifr_Pi3k	421.3024828565	6.07
10	240	Lifr	Gsk3	0.122823623661381	395.921691108318	26	25.38	1	4.70694108578584e-07	0	Lifr_Gsk3	421.301691108318	6.02
11	54	Akt	Lifr	0.56618882474856	397.020494865756	26	24.282	1	8.32336903400233e-07	0	Akt_Lifr	421.302494865756	5.76
12	431	mTor	Jak	0.465337458856917	397.020496692259	26	24.282	1	8.32337692657781e-07	0	mTor_Jak	421.302496692259	5.76
13	432	mTor	Lifr	0.465338156421058	397.020501062787	26	24.282	1	8.32339581258168e-07	0	mTor_Lifr	421.302501062787	5.76
14	53	Akt	Jak	0.566149713542637	397.020501600915	26	24.282	1	8.32339813849892e-07	0	Akt_Jak	421.302501600915	5.76
15	305	Pi3k	Jak	0.00173202223928323	397.020638990924	26	24.281	1	8.32399185357602e-07	0	Pi3k_Jak	421.301638990924	5.76
16	306	Pi3k	Lifr	0.000622528208386818	397.020652026436	26	24.281	1	8.32404818740251e-07	0	Pi3k_Lifr	421.301652026436	5.76

Intersection List

## Warning in htmlTable.data.frame(my_ext_list, align.header = "c", align = "c", :
## my_ext_list is an empty object

Link	Res_delta_XX	adj_pval_XX	Perc_Res_delta_XX	Res_delta_XO	adj_pval_XO	Perc_Res_delta_XO	Total_DelResidual	Tot_Percentage_DelResidual

Summary

Links Added and Residuals

	Model_iteration	Links	res_p_001_XX	res_p_001_XO
1	Init	Init Network	2056.3	1603.72
2	1	Jak->Fgfr	1515	1063.56
3	2	Gsk3->Igfr	970.8	970.63
4	3	Bmp4r->Fgfr	838.79	867.08
5	4	Erk->Raf	798.31	611.48
6	5	Jak->Gsk3	737.95	547.33
7	6	Bmp4r->Smad2	691.88	465.99
8	7	Actr->Bmp4r	651.14	421.3